 | | Vol. 8.42 – 2 December, 2022 |
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| The authors demonstrated that in patients with microsatellite high-instability colorectal cancer and a local inflammatory condition, the primary tumor progressed but its liver metastasis regressed upon Pembrolizumab treatment.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified vtRNA2-1 as a novel regulator of the intestinal barrier via interaction with RNA-binding protein HuR.
[EMBO Reports] |
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| ARD1 was found to possibly potentiate the oncogenic function of NRF2 in human colon cancer by stabilizing the transcription factor.
[Life Sciences] |
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| Scientists demonstrated that YTHDC1 facilitated cytoplasmic export of m6A-modified circFNDC3B, thereby suppressing stem-like and metastatic properties of colorectal cells.
[Cell Death & Disease] |
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| Researchers found that ciclopirox dramatically suppressed gastric cancer xenograft growth in vitro via inhibiting proliferation and stimulating autophagic cell death rather than apoptosis.
[Cell Death & Disease] |
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| Scientists used two experimental mouse models of inflammatory bowel diseases to examine the role of linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation.
[Journal of Pathology] |
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| Investigators targeted the synthetic lethal interaction between PRDX2 and CHK2 in colorectal cancer cells using N-Carbamoyl alanine-loaded chitosan nanoparticles to selectively inhibit the CHK2-null HCT116 cells.
[ACS Biomaterials Science & Engineering] |
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| Membrane-bound complement regulatory proteins (mCRPs) expression in human colon cancer cells were upregulated by STAT3/STAT6/p38 MAPK signaling and mCRPs knockdown reduced colon cancer growth in mice through inducing tumor cell apoptosis.
[International Immunopharmacology] |
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| Scientists provided a new insight into tobacco smoke promoting the progression of gastric cancer, demonstrating that tobacco smoke-induced exosomes promoted the spheroidizing ability, stemness genes expression, and epithelial-mesenchymal transition process of gastric cancer stem cells.
[Medical Oncology] |
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| The authors summarize the recent progress of metabolomics in helping to diagnose and treat inflammatory bowel diseases (IBD), hoping to provide biomarkers and new targets for the diagnosis and treatment of IBD.
[International Immunopharmacology] |
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| Erasca, Inc. announced a clinical trial collaboration and supply agreement with Pierre Fabre for the BRAF inhibitor encorafenib, BRAFTOVI®, within key international territories.
[Erasca, Inc.] |
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| December 12 – 13, 2022
Ghent, Belgium |
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| | Norwegian University of Science and Technology – Trondheim, Norway |
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| | University of Kent – Canterbury, England, United Kingdom |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | University of Illinois Chicago – Chicago, Illinois, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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