 | | Vol. 8.43 – 9 December, 2022 |
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| To gain insight into the process of mucosal healing, researchers longitudinally examined the immune cell composition during intestinal damage and regeneration.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified a cohort of born to be bad early-stage colorectal tumours, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.
[Nature Communications] |
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| Researchers used transcriptomic analyses to dissect the role of HNF4α in the maintenance of jejunal epithelial culture when cultured ex vivo as enteroids, in the presence or absence of compensatory mesenchymal cells.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| The authors evaluated the effects of MakA on the host cell PIP5K1α lipid-signaling pathway and the mechanism by which MakA inhibited cell proliferation and induced cell cycle arrest, particularly in HCT8 colon cancer cells.
[Cell Death & Disease] |
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| Investigators demonstrated that the intestinal KIT signaling declined and deactivated with aging, parallel with epithelial barrier dysfunction.
[Mechanisms of Ageing and Development] |
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| Scientists investigated biological functions and novel downstream signaling pathways affected by endothelin receptor A during colorectal progression.
[International Journal of Oncology] |
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| Using genetically-modified mouse intestinal organoid (enteroid) models, researchers identified 12 different modules of microRNA expression patterns across different combinations of mutations common in colorectal cancer.
[BMC Genomics] |
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| Investigators explored the effects of Wnt7b regulating the Wnt/β-catenin signaling pathway on the proliferation, migration, and invasion of SW480 cells in colorectal cancer.
[Molecular Biology Reports] |
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| Scientists found that Neu5Gc promoted the proliferation of colorectal cancer cells and normal intestinal epithelial cells, and further screened out 98 Neu5Gc targets related to the occurrence and development of colorectal cancer by network pharmacology.
[Naunyn-Schmiedebergs Archives of Pharmacology] |
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| The authors substantiate the potency of medical mushrooms and their secondary metabolites concerning colon cancer carcinogenesis and antimicrobial growth.
[Cancer Cell International] |
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| Sosei Group Corporation announced it had entered translational medicine and R&D agreements with the MRC Weatherall Institute of Molecular Medicine at the University of Oxford, UK and KU Leuven, Belgium.
[Sosei Group Corporation] |
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| January 24 – 26, 2023
Boston, Massachusetts, United States |
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| | Karolinska Institute – Solna, Sweden |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | University of Illinois Chicago – Chicago, Illinois, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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