 | | Vol. 8.44 – 16 December, 2022 |
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| Investigators showed that Werner (WRN) helicase depletion selectively induced p53/PUMA-mediated cell death program in mismatch repair-deficient colorectal cancer cells. The in vitro and in vivo effects of WRN depletion or inhibition were dependent on p53/PUMA-mediated apoptosis.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To explore the molecular mechanisms of gastric cancer chemoresistance, mass spectrometry was performed to detect the genes altered in expression between chemoresistant and chemosensitive gastric cancer.
[Cell Death & Disease] |
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| Investigators tested the effect of chronic G protein-coupled estrogen receptor (GPER) activation on intestinal stem cells of ovariectomized (OVX) mice by injection of the selective GPER agonist G-1 for 28 days, or G-1 stimulation of organoids derived from crypts of OVX mice.
[Clinical Science] |
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| A bioengineered intestinal tubule was used to assess the intestinal efficacy of extracts from five plant accessions belonging to four Lactuca species.
[npj Science of Food] |
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| Scientists identified a redundancy between SMAP1 and Pals1 in the regulation of activation of Arf6/Rac1, thereby controlling cell migration, invasion, and metastasis of colorectal cancer cells.
[Cancer Gene Therapy] |
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| Researchers focused on the potential role of autophagy in sepsis-induced intestinal barrier dysfunction and explored the mechanisms in vivo and in vitro. Excessive apoptosis in intestinal epithelia and a disrupted intestinal barrier were observed in septic mice.
[American Journal of Pathology] |
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| The authors investigated the effects and mechanisms of isosteviol against intestinal inflammation using tumor necrosis factor-α-treated Caco-2 cells as an in vitro inflammatory model.
[International Immunopharmacology] |
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| Researchers evaluated the effect of thymoquinone on 5-fluorouracil pharmacokinetics in vivo and in vitro on human colorectal cancer cell lines.
[Human & Experimental Toxicology] |
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| Investigators studied the function and mode of action of TIGD1 in the development of colon cancer. A series of cell assays were conducted to assess the function of TIGD1 in the proliferation and migration of colon cancer, and flow cytometry was used to explore its effects on apoptosis and the cell cycle.
[Cancer Biotherapy and Radiopharmaceuticals] |
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| The authors summarize current evidence and perspectives on combination therapies in inflammatory bowel diseases.
[International Immunopharmacology] |
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| Researchers summarize and update the clinical manifestation and application of creeping fat and the underlying molecular mechanism involved in the pathogenesis of intestinal inflammation and fibrosis in Crohn’s disease.
[United European Gastroenterology Journal] |
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| Qu Biologics Inc. announced the collaboration with Associate Professor Jonas Fuxe and his team at the Karolinska Institute in Stockholm, Sweden, to characterize the molecular targets of Qu’s immunomodulator therapy by assessment of biopsies from patients with moderate-to-severe Crohn’s disease.
[Qu Biologic, Inc.] |
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| January 22 – 25, 2023
Santa Fe, New Mexico, United States |
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| | National Institutes of Health – Nashville, Tennessee, United States |
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| | Karolinska Institute – Solna, Sweden |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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