 | | Vol. 9.00 – 6 January, 2023 |
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| Scientists reported that DDX17 expression was increased in colorectal cancer (CRC) tissues compared with noncancerous mucosa tissues and further upregulated in CRC liver metastasis compared with patient-paired primary tumors.
[Cell Death & Disease] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| It was found that glycolytic activity was necessary to maintain intestinal stem cell (ISC) self-renewal and that limiting glycolysis contributed to the generation of secretory lineages from ISCs. The inability to fine-tune glycolysis in ISCs subsequently disturbed the balance between self-renewal and differentiation.
[Cellular And Molecular Gastroenterology And Hepatology] |
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| The authors investigated the effects of expression and regulation of vitamin D receptors (VDR) on the protection of radiation-induced intestinal injury, conducted radiosensitivity in vitro experiments, and explored the initial mechanism of VDR in regulating radiosensitivity of intestinal epithelial cells.
[Journal Of Cellular And Molecular Medicine] |
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| Investigators explored the specific mechanism and function of baicalin on colon cells. Cell proliferation, viability, and cell cycle phases were evaluated using MTT, colony formation, and flow cytometry assays, respectively.
[American Journal Of Chinese Medicine] |
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| Researchers demonstrated that olfactomedin 4 (OLFM4) regulated inflammation and cancer progression differently; ablation of OLFM4 promoted cancer metastasis via stemness and epithelial-mesenchymal transition.
[Cancer Gene Therapy] |
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| Investigators revealed that expressions of MAD2L1 and TEAD4 in colorectal cancer (CRC) tissues and CRC cell lines were significantly higher than those in adjacent epithelial tissues and normal intestinal epithelial cell line NCM460.
[Cancer Gene Therapy] |
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| Scientists evaluated the anti-tumoral effect of epibrassinolide as well as the autophagy involvement in the aggressive forms of colon cancer cell lines as well as in vivo SCID mouse xenograft colon cancer model for the first time.
[The International Journal of Biochemistry & Cell Biology] |
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| Investigators studied three traditional Chinese medicines, Antler’s extract, Ganoderma lucidem, and Anrodia camphorata for their anti-proliferative, anti-metastatic, and apoptotic activity to explore their anti-cancer activity against colon cancer cells and its underlying mechanism.
[BMC Cancer] |
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| Researchers investigated the potential antigenotoxic and cytotoxic effects of cell-free-supernatant postbiotics derived from Saccharomyces boulardii by applying SOS chromotest and MTT assay on HT-29 cell lines.
[Probiotics And Antimicrobial Proteins] |
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| The authors discuss the multiple functions of Paneth cells, and the mechanisms and consequences of Paneth cell dysfunction while providing an overview of the tools available for studying Paneth cells.
[EMBO Molecular Medicine] |
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| Cellf BIO announced the beginning of its Phase I clinical trial for its BioSphincter™ Implant for the treatment of severe passive fecal incontinence. The FDA cleared the company’s Investigational New Drug application, and the Institutional Review Board approved the trial to begin enrolling participants.
[Cellf BIO (Globe Newswire)] |
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| ProPhase Labs, Inc. announced it has completed its previously announced acquisition of the worldwide exclusive rights to the BE-Smart Esophageal Pre-Cancer diagnostic screening test and related intellectual property assets from Stella Diagnostics, Inc.
[ProPhase Labs, Inc.] |
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| February 19 – 22, 2023
Banff, Alberta, Canada |
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| | University Medical Center Freiburg – Freiburg, Germany |
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| | UTHSC-Houston – Houston, Texas, United States |
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| | National Institutes of Health – Nashville, Tennessee, United States |
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| | Karolinska Institute – Solna, Sweden |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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