 | | Vol. 9.02 – 20 January, 2023 |
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| Scientists revealed a previously unrecognized role of fructose 1,6-bisphosphate (FBP1) as a protein phosphatase and established the critical role of FBP1-mediated IκBα dephosphorylation in colorectal tumorigenesis.
[Cell Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that discs large 1 (Dlg1), although dispensable for polarity and cellular turnover during intestinal homeostasis, were required for intestinal stem cell survival in the context of increased Wnt signaling.
[Cell Stem Cell] |
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| Researchers showed that in hyperglycemic conditions, metformin increased basolateral intestinal glucose uptake, and its metabolites produced in the gut, through the portal vein reach the liver and reduce hepatic glucose production.[Proceedings Of The National Academy Of Sciences Of The United States Of America]
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| To study the mechanism of cetuximab resistance in KRAS wild-type colorectal cancer (CRC) patients, scientists evaluated the impact of circIFNGR2 on CRC and detected the association among circIFNGR2, miR-30b, and KRAS via various experiments such as cell functional experiments.
[Cell Death & Disease] |
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| To identify a novel target for metastasis of colorectal cancer, the authors conducted a gene microarray analysis using extracted RNA from the blood of preclinical models.
[Cell Death Discovery] |
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| Scientists observed the role of aspirin on the chemotherapy resistance of colorectal cells by CCK8 assay. They found that aspirin could effectively enhance the chemosensitivity of CT26 and HCT116 colorectal cancer cell lines.
[Cancer Cell International] |
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| Researchers tested whether electroacupuncture could protec intestinal epithelial cells in patients with endotoxemia by regulating the mitochondrial fusion/fission dynamics, and protect the intestinal barrier by activating the HO-1/PINK1 pathway.
[Oxidative Medicine And Cellular Longevity] |
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| Given the targeting action of lactoferrin (LF) by binding to the LF receptors of intestinal epithelial cells and of folic acid (FA) by binding to the FA receptors of macrophages, investigators developed an oral dual-targeting nanosystem.
[International Journal Of Biological Macromolecules] |
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| Researchers investigated mechanisms underlying enterotoxigenic Escherichia coli (ETEC)-induced diarrhea and found that the mTORC1 pathway played a role in the host response to ETEC F4 infection.
[Microbes And Infection] |
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| The authors provide a comprehensive insight into the interplay between thyroid hormone metabolism and gut homeostasis.
[Thyroid] |
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| Biomea Fusion, Inc. announced that the first patient has been dosed in COVALENT-102, the company’s Phase I/Ib trial of BMF-219, an oral, selective, covalent menin inhibitor in patients with KRAS-mutated unresectable, locally advanced, or metastatic cancers including colorectal cancer.
[Biomea Fusion, Inc.] |
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| February 9 – 12, 2023
Cancun, Mexico |
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| | IRCCS Candiolo Cancer Institute – Turin, Italy |
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| | Midwestern University – Glendale, Arizona, United States |
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| | Virginia Tech – Blacksburg, Virginia, United States |
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| | Pompeu Fabra University – Barcelona, Spain |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
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Intestinal Cell News
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