 | | Vol. 9.03 – 27 January, 2023 |
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| Researchers applied a combination of transcriptomic and imaging approaches for an in-depth analysis of immune checkpoint blockade (ICB)-naive and ICB-treated DNA mismatch repair-deficient colon cancers, as well as in vitro functional assays.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To decipher human intestinal–immune crosstalk during development, investigators generated human intestinal organoids (HIOs) containing immune cells by transplanting HIOs under the kidney capsule of mice with a humanized immune system.
[Nature Biotechnology] |
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| Scientists hypothesized that chlorogenic acid (CGA) exerted intestinal health effects via modulating intestinal stem cell functions. Lgr5-EGFP mice and intestinal organoids derived from the above mice were treated for 14 days and 3 days using CGA solution, respectively.
[Journal Of The Science Of Food And Agriculture] |
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| Researchers demonstrated that stem cell factor functioned as a pro-inflammatory mediator in mucosal tissues and that specific neutralization of SCF248 could be a viable therapeutic option to reduce intestinal inflammation and promote mucosal wound repair in individuals with inflammatory bowel disease.
[Inflammatory Bowel Diseases] |
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| Investigators revealed that Prohibitin 2 (PHB2) expression was elevated in precancerous adenomas and colorectal cancer, which promoted cell proliferation and tumorigenesis of colorectal cancer.
[Cell Death & Disease] |
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| Scientists found that a novel small molecule, PDS-0330, may prevent colorectal progression and metastasis by interfering with claudin-1 binding to metastatic oncogene Src. This resulted in the inhibition of the resistance to anoikis, invasion, and tumorigenic potential in claudin-1 overexpressed cells.
[Biomedicine & Pharmacotherapy] |
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| The authors studied whether nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and engulfment and cell motility protein-1 (ELMO1) interacted with each other directly or indirectly to regulate bacterial sensing. The polymorphism of NOD2 is known to be linked to Crohn’s disease pathogenesis.
[Virulence] |
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| Loss of Frizzled-7, an important element in the Wnt signaling, interrupted the differentiation of intestinal stem cells into absorptive progenitors instead of secretory progenitors, precursors of goblet and Paneth cells.
[Development] |
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| Researchers investigated the correlation between celecoxib-induced endoplasmic reticulum stress and the effects of celecoxib against cell death signaling. Treatment of human colon cancer HCT116 cells with celecoxib reduced their viability and resulted in a loss of mitochondrial membrane potential.
[Naunyn-Schmiedeberg’s Archives of Pharmacology] |
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| The authors provide an overview of recent research in ferroptosis and its potential role as a therapeutic target in colorectal cancer. They also propose future research directions that could help to enhance the current understanding of ferroptosis in colorectal cancer.
[British Journal Of Cancer] |
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| Investigators mainly focus on Rho GTPases and their possible mechanisms in inflammatory bowel disease pathogenesis. The therapeutic possibility of Rho GTPases is also discussed.
[Cell Death Discovery] |
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| SOTIO Biotech announced that the first patient was dosed in its Phase II AURELIO-05 combination trial of nanrilkefusp alfa, an IL-15 superagonist, and cetuximab in patients with colorectal cancer.
[SOTIO Biotech] |
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| February 13 – 16, 2023
Breckenridge, Colorado, United States |
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| | University of Oxford – England, United Kingdom |
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| | Imperial College London – London, United Kingdom |
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| | UT Southwestern Medical Center – Dallas, Texas, United States |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | IRCCS Candiolo Cancer Institute – Turin, Italy |
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