 | | Vol. 9.07 – 24 February, 2023 |
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| Scientists reported that knockdown, forced overexpression, and pharmacologic inhibition of angiotensin I-converting enzyme 2 (ACE2) in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis.
[npj Precision Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that overexpression of miR-17-5p led to less apoptosis and lower drug sensitivity in vitro and in vivo under the 5-fluorouracil (5-FU) treatment, which indicated miR-17-5p led to 5-FU chemotherapy resistance.
[Cell Death & Disease] |
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| Ibrutinib sensitized colorectal cancer (CRC) to ferroptosis inducers, suggested by reduced CRC cell viability, proliferation, and decreased antioxidant protein levels in CRC cells after combination treatment of Ibrutinib and RSL3 or Ibrutinib and Erastin both in vivo and in vitro.
[Cell Death & Disease] |
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| Researchers identified an EGF family member, EPIREGULIN, which was robustly expressed in the developing human crypt. Enteroids generated from the developing human intestine were dominated by stem and progenitor cells, and featured little differentiation and no spatial organization.
[JCI Insight] |
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| The authors reported that human telomerase reverse transcriptase (hTERT) promoted gastric cancer invasion and metastasis by recruiting p50 to synergistically inhibit pleckstrin homology domain-containing family A member 7 (PLEKHA7) expression.
[Oncogene] |
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| Scientists determined the efficacy of ursolic acid (UA) on colorectal cancer SW620 cells with respect to the proliferation, migration, clonality, apoptosis, cell cycle, and Wnt/β-catenin signaling cascade, with assessment of the effect of UA on normal colonic NCM460 cells.
[Journal of Agricultural and Food Chemistry] |
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| Lactobacillus plantarum was treated with curcumin, and its resistance to the curcumin was determined. After then the cell-free supernatants of untreated bacteria and bacteria treated with curcumin were isolated and their anti-proliferative properties against HT-29 colon cancer cells were compared.
[Scientific Reports] |
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| Researchers investigated the effects and mechanisms of valine supplementation on triglyceride synthesis in porcine intestinal epithelial cells.
[Scientific Reports] |
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| Investigators evaluated the function of lncRNA ADAMTS9-AS2 in colorectal cancer and its fundamental mechanism. Levels of ADAMTS9-AS2, miR-27a-3p, and B-cell translocation gene 2 (BTG2) were measured by qPCR.
[Journal Of Oncology] |
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| The authors discuss newfound factors that regulate colorectal cancer cell dissemination and colonization of distant organs, such as genetic mutations, identification of metastasis-initiating cells, epithelial–mesenchymal transition, and the tumor microenvironment.
[Trends in Pharmacological Sciences] |
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| Scientists highlight the use of organoids and organs-on-chips as complementary reference tools in treating colorectal cancer from the perspective of clinical efficacy predictability.
[Cell Death & Disease] |
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| Investigators review the evidence for the current management and recent advances in the management of small intestine adenocarcinoma, neuroendocrine tumors, and gastrointestinal stromal tumors.
[Current Treatment Options in Oncology] |
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| Cancer surgery experts launched a network of hospitals across India to support a country-wide clinical trial exploring how giving colon cancer patients chemotherapy before surgery cuts their risk of the disease coming back.
[University of Birmingham] |
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| March 26 – 31, 2023
Ventura, California, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | Luxembourg Institute of Health – Esch-sur-Alzette, Luxembourg |
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| | Vanderbilt-Ingram Cancer Center – Nashville, Tennessee, United States |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | Beckman Research Institute – Monrovia, California, United States |
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