 | | Vol. 9.10 – 17 March, 2023 |
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| Researchers found that Th17 cell-inducing gut bacteria generated an unfolded protein response (UPR) in intestinal epithelial cells (IECs). Subtilase cytotoxin expression or genetic removal of X-box binding protein 1 in IECs caused a UPR and increased Th17 cells, even in antibiotic-treated or germ-free conditions.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that Enterovirus A71-infected cells were specifically extruded from the apical surface of differentiated human colon organoids, as observed by confocal microscopy.
[Nature Microbiology] |
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| Investigators identified the mouse intestinal stem cell niche as a complex, multi-layered structure that encompassed distinct mesenchymal and smooth muscle populations.
[Developmental Cell] |
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| The authors identified a specific, hotspot mutation in SMARCA4 which resulted in a conversion from arginine to tryptophan at residue 1157 (R1157W) in human colorectal cancer (CRC) tissues associated with higher-grade tumors and controled CRC progression.
[npj Precision Oncology] |
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| Researchers identified a novel lncRNA, CACClnc, which was upregulated and associated with chemoresistance and poor prognosis in colorectal cancer.
[Oncogene] |
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| Exploration of the TCGA database indicated that C4orf19 was markedly downregulated in colorectal cancer (CRC) tissues in comparison to that observed in normal colonic tissues, suggesting its potential association with CRC behaviors.
[Oncogene] |
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| A novel functional lncRNA LOC105369504 was identified by microarray analysis. In colorectal cancer, LOC105369504 expression was markedly decreased and resulted in distinct variations in proliferation, invasion, migration, and epithelial-mesenchymal transition in vivo and in vitro.
[Cell Death Discovery] |
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| Scientists investigated the anti-colorectal cancer effect of N-methylsansalvamide (MSSV). MSSV exhibited the inhibition of the proliferation in HCT116 cells via induction of G0/G1 cell cycle arrest by downregulating CDK 2, CDK6, cyclin D, and cyclin E, and upregulating p21WAF1 and p27KIP1.
[Frontiers In Pharmacology] |
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| Salix mucronata and Triticum spelta plant extracts were prepared using five different solvents and examined for their cytotoxicity against liver HepG2 cancer cell line. It was found that Salix mucronata ethanolic extract was high in antioxidant mediated anti-cancer activity.
[Scientific Reports] |
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| Researchers identified key regulatory genes and pathways associated with oxaliplatin (OXA) resistance. The Gene Expression Omnibus GSE42387 dataset containing gene expression profiles of parental and OXA-resistant LoVo cells was applied to explore potential targets.
[Scientific Reports] |
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| The authors focus on cystic fibrosis transmembrane conductance regulator (CFTR) in the intestine and the implications of the subpopulation of CFTR high expresser cells in cystic fibrosis, intestinal physiology, and the pathophysiology of intestinal diseases.
[Heliyon] |
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| The National People’s Congress and the Chinese People’s Political Consultative Conference have boosted science and technology in the national agenda.
[Nature] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | Amsterdam UMC – Amsterdam, Netherlands |
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| | University of Vermont – Burlington, Vermont, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University of Houston – Houston, Texas, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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