Intestinal Cell News Volume 9.11 | Mar 24 2023

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    Noshin Noorjahan
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    203-03-24 | ICN 9.11


    Intestinal Cell News by STEMCELL Technologies
    Vol. 9.11 – 24 March, 2023
    TOP STORY

    Epithelial Nlrp10 Inflammasome Mediates Protection against Intestinal Autoinflammation

    Scientists showed that mouse Nlrp10 was expressed in distal colonic intestinal epithelial cells and modulated by the intestinal microbiome.
    [Nature Immunology]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Blocking Dectin-1 Prevents Colorectal Tumorigenesis by Suppressing Prostaglandin E2 Production in Myeloid-Derived Suppressor Cells and Enhancing IL-22 Binding Protein Expression

    Investigators found that azoxymethane-dextran-sodium-sulfate-induced and ApcMin-induced intestinal tumorigenesis were suppressed in Clec7a−/− mice independently from commensal microbiota.
    [Nature Communications]

    Full Article

    Tumor Suppressive Role of the Musculoaponeurotic Fibrosarcoma Gene in Colorectal Cancer

    Researchers investigated whether microRNAs miR-200c, miR-302s, and miR-369s inhibited colorectal tumorigenesis in CPC;Apc mice, which were prone to colon and rectal polyps.
    [iScience]

    AbstractGraphical Abstract

    MORC4 Plays a Tumor-Promoting Role in Colorectal Cancer via Regulating PCGF1/CDKN1A Axis In Vitro and In Vivo

    The authors investigated the role of MORC family CW-type zinc finger 4 (MORC4) in colorectal cancer malignant behaviors, with an emphasis on polycomb group ring finger 1 (PCGF1)/cyclin-dependent kinase inhibitor 1A (CDKN1A) axis.
    [Cancer Gene Therapy]

    Abstract

    NR3C2 Inhibits the Proliferation of Colorectal Cancer via Regulating Glucose Metabolism and Phosphorylating AMPK

    Scientists investigated the roles and mechanisms of NR3C2 in colorectal cancer (CRC). The expression of NR3C2 in CRC tumors and paired paracancerous tissues of 71 CRC patients and five CRC cell lines was detected by western blotting, immunohistochemistry, and real-time reverse-transcription PCR.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Long Non-Coding RNA CR46040 Is Essential for Injury-Stimulated Regeneration of Intestinal Stem Cells in Drosophila

    Investigators identified a long non-coding RNA, CR46040, that was essential for the injury-induced intestinal stem cell (ISC) regeneration in Drosophila. Loss of CR46040 greatly impaired ISCs proliferation in response to tissue damage caused by dextran sulfate sodium treatment.
    [Genetics]

    Abstract

    PHKG2 Regulates RSL3-Induced Ferroptosis in Helicobacter pylori Related Gastric Cancer

    The authors demonstrated that Helicobacter pylori infection increased the sensitivity of gastric cancer cells to RAS-selective lethal3 (RSL3)-induced ferroptosis. The molecular subtypes mediated by ferroptosis-related genes were associated with tumor microenvironment cell infiltration and patient survival.
    [Archives of Biochemistry and Biophysics]

    AbstractGraphical Abstract

    LncRNA HOXB-AS4 Promotes Proliferation and Migration of Colorectal Cancer via the miR-140-5p/hdac7 Axis

    Researchers found that HOXB-AS4 was markedly upregulated in tumor tissues compared to precancerous tissues. Loss-of-function assays in HT29 and SW480 cells confirmed that knockdown of HOXB-AS4 inhibited proliferation and migration, and promoted apoptosis.
    [Biotechnology and Genetic Engineering Reviews]

    Abstract

    The Roles and Molecular Mechanisms of Long Non-Coding RNA WT1-AS in the Maintenance and Development of Gastric Cancer Stem Cells

    Investigators showed that Wilms’ tumor 1 antisense RNA (WT1-AS) negatively regulated WT1 expression in gastric cancer stem cells.
    [Heliyon]

    Full Article
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    REVIEWS

    Noncoding RNAs as Regulators of STAT3 Pathway in Gastrointestinal Cancers: Roles in Cancer Progression and Therapeutic Response

    The authors elaborate on the tumor-promoting role of STAT3 signaling in gastrointestinal (GI) tumors. Subsequently, they discuss the oncogenic as well as tumor suppressor functions and mechanism of action of noncoding RNAs that are known to modulate STAT3 signaling in GI cancers.
    [Medicinal Research Reviews]

    Abstract

    The Emerging Roles of the Cytoskeleton in Intestinal Epithelium Homeostasis

    Scientists highlight the contribution of the cell cytoskeleton- actin, microtubules, and intermediate filaments- to intestinal epithelium homeostasis. With a focus on enterocytes, they discuss the role of these networks in the formation and maintenance of cell-cell and cell-matrix junctions.
    [Seminars in Cell & Developmental Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Goldenring’s Gastrointestinal Research Contributions Lauded

    James Goldenring, the Paul W. Sanger Professor of Experimental Surgery at Vanderbilt University Medical Center, will receive the American Gastroenterological Association’s Distinguished Achievement Award in Basic Science for making significant contributions to understanding gastrointestinal disease.
    [Vanderbilt University Medical Center]

    Press Release

    First Lady Casey DeSantis Announces Florida Becomes First State in the Nation to Collect Cancer Recurrence Data

    First Lady Casey DeSantis announced that Florida will be the first state in the US to collect cancer recurrence data – the Cancer Connect Collaborative’s first action to remove data access barriers for easy and timely research.
    [Florida Government]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Tumor-on-Chip Metastasis Model

    Oslo University Hospital – Oslo, Norway

    Academic Pathologist – Liver Pathology

    University of Vermont – Burlington, Vermont, United States

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    University of Cambridge – Cambridge, England, United Kingdom

    Research Assistant Professor – Cell Molecular Biology

    University of Houston – Houston, Texas, United States

    Postdoctoral Fellow – Cancer Imaging & Drug Delivery

    University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States

    > See All Jobs

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