 | | Vol. 9.12 – 31 March, 2023 |
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| scRNA-seq was conducted on 95 551 cells from endoscopic biopsies of low-grade intraepithelial neoplasia, well/moderately/poorly differentiated early gastric cardia adenocarcinoma and their paired adjacent nonmalignant biopsy samples. Large-scale clinical samples and functional experiments were employed.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using genetically engineered and carcinogen-induced mouse models of intestinal neoplasia, scientists observed that impaired differentiation was a conserved event preceding cancer development.
[Science Advances] |
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| Investigators detected abnormal hypermethylation of the zinc-finger proteins (ZNF) 334 gene in colorectal cancer tissues compared with normal tissues, and this modification downregulated the expression of ZNF334.
[Cell Death & Disease] |
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| Through mass spectrometric, co-immunoprecipitation, and immunofluorescent assays, researchers found that oncogene protein arginine methyltransferase 5 (PRMT5) interacted with SMAD4 under TGF-β1 treatment.
[Oncogene] |
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| Scientists synthesized a potent and selective Takeda G protein-coupled receptor-5 (TGR5) agonist OM8 with high distribution in intestinal tract and investigated its effect on intestinal epithelial cell apoptosis and ulcerative colitis treatment.
[Acta Pharmacologica Sinica] |
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| The authors investigated the effects of dietary fiber and its metabolites on mucus production in the colonic mucosa. Mice were fed a partially hydrolyzed guar gum-containing diet and a fiber-free diet.
[npj Science of Food] |
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| Investigators defined that Mat2a was essential for intestinal development and metabolite S-adenosyl-L-methionine played an important role in intestinal homeostasis.
[Development] |
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| Researchers investigated the role of casein-derived peptide YFYPEL in necrotizing enterocolitis (NEC) cells and animal models. They synthesized YFYPEL and analyzed its protective effects on NEC both in vitro and in vivo.
[Food & Function] |
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| Scientists demonstrated that DMC-BH had stronger cytostatic ability than curcumin against colorectal cancer cells in vitro and in vivo. It effectively inhibited the proliferation and invasion and promoted the apoptosis of HCT116 and HT-29 cells.
[Aging] |
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| The proliferation of colorectal cancer cells was evaluated using the CCK8 assay, colony formation assay, and EdU assay. Cell migration was examined through wound healing and Transwell analyses.
[The Journal of Gene Medicine] |
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| The authors review the effects of polyunsaturated fatty acid (PUFA) on tumorigenesis and current knowledge that supports the association of the enzymes involved in the PUFA synthesis pathway with colorectal cancer tumorigenesis and progression are reviewed.
[Animal Cells and Systems] |
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| Merck announced that the US FDA has granted full approval to KEYTRUDA for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options.
[Merck] |
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| April 24 – 26, 2023
Hinxton, England, United Kingdom |
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| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | University of Houston – Houston, Texas, United States |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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