 | | Vol. 9.13 – 14 April, 2023 |
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| The authors showed that mRNA and chromatin profiles of abundant CD81− PDGFRAlo mouse stromal cells resembled those of trophocytes and that both populations provided crucial canonical Wnt ligands.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To address whether insulin-like growth factor II mRNA-binding proteins (IMP) 3 controled cancer cell survival, researchers analyzed cell death pathways in in vitro and in vivo experiments after IMP3 downregulation by siRNA or an antisense oligonucleotide.
[Cell Death & Disease] |
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| Scientists observed that Nodal enhanced colorectal cancer cells’ proliferative rate, motility, invasiveness, and epithelial–mesenchymal transition in vivo and in vitro.
[Cell Death & Disease] |
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| Investigators studied a novel protein prokineticin 2,also known as Bv8, as a key pro-tumoral factor in colorectal cancer progression in in vitro and ex vivo settings.
[Frontiers in Immunology] |
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| Researchers demonstrated that RAF1, but not its kinase activity, played a crucial role in the proliferation of both Microsatellite Stable and Microsatellite Instable colorectal cancer cell line-derived spheroids and patient-derived organoids, and independently of KRAS mutation status.
[Oncogene] |
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| Scientists reported that MRTX1133 treatment caused reversible growth arrest in KRASG12D-mutated colorectal cancer cells, accompanied by partial reactivation of RAS effector signaling.
[Oncogene] |
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| The authors used mass cytometry of isogenic human colon organoids and patient-derived cancer organoids to capture oncogenic signaling, cell phenotypes, and differentiation states in a high-dimensional single-cell map.
[Journal of Cell Biology] |
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| Investigators reported that methyltransferase-like 3, a critical enzyme for N6-methyladenosine methylation, was required for intestinal stem cells maintenance as its deletion resulted in fast loss of stemness markers but had no effect on cell proliferation.
[Stem Cell Reports] |
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| By combining bioimaging and genetic tools with artificial intelligence algorithms applied to colorectal cancer cell, researchers found that the Adenomatous Polyposis Coli (APC)-dependent actin pool contributed to sustaining levels of F-actin, as well as E-cadherin and Occludin protein levels at cell junctions.
[iScience] |
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| Two types of human gastric cancer cells were used to establish tumor xenograft models in nude mice that were treated with polyphyllin I to observe tumor growth, while cells also were cultured for in vitro studies.
[Frontiers in Pharmacology] |
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| ScRNA-seq was performed on two tumors collected from patients with alpha-fetoprotein-producing gastric cancer (AFPGC). InferCNV and sub-clustering were applied to identify typical AFPGC cells, followed by AddModuleScore, pathway enrichment, Pseudo-time, and Scenic analyses.
[Cancer Medicine] |
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| The authors outline the management of inflammatory bowel disease (IBD) in pregnancy and the safety of IBD therapies, including novel agents, with regard to both maternal and fetal health.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists review the biological features of gastric stem cells at various locations of the stomach under homeostatic conditions, as demonstrated by reporter mice, lineage tracing, and single cell sequencing.
[Cellular Oncology] |
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| Merck and Eisai provided updates on two Phase III trials, LEAP-003 and LEAP-017 investigating KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai.
[Merck] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | City of Hope – Monrovia, California, United States |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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