 | | Vol. 9.14 – 21 April, 2023 |
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| Investigators generated a colon-specific conditional targeted deletion to evaluate epithelial program regulator (EPR) in vivo functions in mice.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that DDB1 and CUL4 Associated Factor 1 (DCAF1) phosphorylated enhancer of Zeste Homolog 2 (EZH2) at T367 to augment its nuclear stabilization and enzymatic activity in colon cancer cells.
[Nature Communications] |
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| Using proteomic analysis, the authors identified bromodomain-containing protein 3 (BRD3), an acetyl-lysine reading epigenetic regulator, as one of nuclear TYRO3’s substrates.
[Science Advances] |
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| Researchers identified cap methyltransferase 1 (CMTR1) as a novel oncogene in colorectal cancer (CRC). Based on The Cancer Genome Atlas database exploration and human tissue microarray analysis, they found that CMTR1 expression was markedly higher in CRC tissues than in adjacent normal tissues.
[Cell Death & Disease] |
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| Immunohistochemistry was used to determine claudin 1 (CLDN1) expression in post-chemotherapy liver metastases from colorectal cancer patients. The effects of oxaliplatin on membrane CLDN1 expression were evaluated by in vitro and in vivo experiments including flow cytometry and immunofluorescence.
[Cell & Bioscience] |
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| Scientists reported that serotonin transporter transports serotonin into colorectal cancer cells, enhancing Yes-associated protein (YAP) expression and promoting in vitro and in vivo colon cancer cell growth.
[Cell Communication and Signaling] |
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| Biological information analysis was applied to detect the expression and the correlation of peroxisome proliferator activated receptors (PPARs) and solute carrier family 27 member 2 (SLC27A2) in colorectal cancer.
[BMC Cancer] |
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| Researchers statistically analyzed the relationship between vitamin D receptor (VDR) expression and colorectal cancer (CRC) development in patients and detected invasion and apoptosis in CRC cells with VDR overexpression and interference.
[BMC Cancer] |
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| A Mannan rich fraction and three yeast cell wall products were compared by examining their impact on intestinal barrier function using a Jejunal model of intestine in response to a bacterial challenge using Salmonella LPS.
[Porcine Health Management] |
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| The authors highlight the emerging evidence on the clonal evolution of colorectal liver metastasis and review recent insights into the molecular mechanisms orchestrating the bidirectional interactions between metastatic colorectal cancer cells and the unique liver microenvironment.
[Cancer and Metastasis Reviews] |
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| Agenus Inc. has been granted Fast Track Designation from the US FDA for the investigation of the combination of botensilimab and balstilimab. The designation is for patients with non-microsatellite instability-high/deficient mismatch repair metastatic colorectal cancer with no active liver involvement.
[Agenus Inc.] |
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| April 26 – 28, 2023
Singapore, Singapore |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
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