 | | Vol. 9.15 – 28 April, 2023 |
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| To explore the contribution of dehydrogenases to the low oxygen concentration response of tumor cells, scientists used siRNAs targeting 163 dehydrogenase-coding genes and discovered that glutamate dehydrogenase 1 played a critical role in regulating colorectal cancer cell survival under hypoxia.
[EMBO Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators discovered that hypoxia reduced soluble ST2 (sST2) expression in colorectal cancer (CRC) cells and explored the associated molecular mechanisms, including the expression of key regulators of ST2 gene transcription in hypoxic CRC cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors found that cinnamaldehyde (CA) could exert an antitumor effect in HCT-116 cell lines. Target fishing, molecular imaging, and live-cell tracing using an alkynyl–CA probe revealed that the heat shock 60 kDa protein 1 (HSPD1) protein was the target of CA.
[Phytotherapy Research] |
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| Using the haploid chronic myelogenous leukemia cell line HAP1, RNA sequencing was performed to identify genes whose expression was increased by APC disruption and reversed by β-catenin knockdown.
[Cancer Medicine] |
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| Flow cytometry and immunohistochemical analysis were checked for immune infiltration on MC38 mice model. Human colorectal cancer tissues were tested with RT-qPCR.
[Cancer Medicine] |
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| Scientists treated three cell lines with HAMLET to evaluate cell metabolic activity and viability, flow cytometry of apoptotic and necrotic cells, pro- and anti-apoptotic genes, and protein expressions.
[Journal of Cancer Research and Clinical Oncology] |
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| Researchers investigated whether CDK12 could be a potential therapeutic target for patients with colorectal cancer and clarified its underlying mechanism. They found that CDK12, but not CDK13, was required for CRC survival.
[Experimental Cell Research] |
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| LXR inhibitor SR9243-loaded immunoliposomes improved the reduction of clonogenicity, stemness, and lipogenesis in CD133 + cancer stem cells in vitro, boosted reactive oxygen species generation, and induced apoptosis.
[Medical Oncology] |
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| UBR5 and proline-rich tyrosine kinase 2 (PYK2) expression levels were detected by RT-qPCR. The levels of UBR5, PYK2, and mitochondrial oxidative phosphorylation complexes were detected by western blot analysis.
[Journal of Biochemical and Molecular Toxicology] |
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| The authors introduce the origins and applications of cell-free RNA (cfRNA), describe its detection and qualification methods in liquid biopsy, and summarize a comprehensive list of cfRNA biomarkers in different gastrointestinal cancer types.
[WIREs RNA] |
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| Scientists summarize recent progress in the identification of hormones associated with intestinal stem cells. Several hormones, including thyroid hormone, glucagon-like peptide-2, androgens, and progastrin promote the development of intestinal stem cells.
[Stem Cell Research & Therapy] |
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| Investigators present the characteristics of circulating or extracellular miRNAs, lncRNAs, and circRNAs in gastric juice, allowing their use in gastric cancer prevention, diagnosis, prognosis, and monitoring therapy.
[Frontiers in Physiology] |
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| The Icahn School of Medicine at Mount Sinai announced the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure a host of diseases from leukemia to Alzheimer’s disease, breast cancer, and airway diseases.
[Mount Sinai] |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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