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| To analyze the responsiveness of gastric cancer to PARP inhibitors, scientists exploited a gastroesophageal adenocarcinoma platform of patient-derived xenografts (PDX) and PDX-derived primary cells.
[Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established a mouse model that replicated two common genetic and epigenetic events observed in human colorectal cancers: Apc mutation and p16 epimutation.
[Journal of Experimental & Clinical Cancer Research] |
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| Researchers used in-depth quantitative proteomics combined with survival analysis, revealing that the ribosome protein U3 small nucleolar RNA-associated protein 18 homolog (UTP18) was consistently upregulated in the progression of colorectal adenoma to carcinoma.
[Cell Reports] |
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| Transcriptome results suggested that NSUN2 expression was significantly upregulated in peritoneal metastasis (PM) and patients with high NSUN2 expression of PM predicted a worse prognosis.
[Oncogene] |
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| The authors found that glutathione peroxidase-2 was overexpressed and negatively correlated with poor prognosis by using clinical gastric cancer samples for validation.
[Oncogene] |
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| Investigators analyzed the expression of WD Repeat Domain Phosphoinositide Interacting 2 (WIPI2) in colorectal cancer versus normal tissues through The Cancer Genome Atlas.
[Frontiers in Oncology] |
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| Researchers found that dihydroartemisinin (DHA) inhibited cell viability in HCT116 and SW620 cells. Moreover, DHA decreased cell clonogenicity, and improved oxaliplatin sensitivity.
[Drug Development Research] |
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| Scientists analyzed the anti-proliferative potential and genotoxicity of thermo-oxidatively treated stigmasterol, stigmasteryl linoleate, and oleate.
[Scientific Reports] |
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| A series of cell culture studies were conducted, followed by their interrogation in patient-derived 3D organoid models to evaluate Ginseng’s anti-cancer activity in colorectal cancer.
[Carcinogenesis] |
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| Enterovirus 71 (EV71) was exploited to be a novel oncolytic virus in colorectal cancer. It was revealed that EV71 infection could selectively cause colorectal cancer cells cytotoxicity but not primary intestinal epithelial cells.
[Advanced Biology] |
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| To better understand the underlying mechanism and define relationships between environmental factors and young-onset-colorectal cancer development, long-term prospective studies are needed with lifestyle data collected from childhood.
[Nature Reviews Disease Primers] |
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| The authors review the current status and progress of research on cancer-associated fibroblastss-derived exosomal non-coding RNAs in colorectal cancer.
[Frontiers in Immunology] |
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| Scientists highlight the crosstalk between the tumor immune microenvironment in colorectal cancer (CRC) and the immunogenicity of CRC cells based on the circadian clocks.
[Immunology] |
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| The international registry of colorectal cancer patients and relatives, supporting earlier diagnosis and research to improve patient outcomes, has received $8.7 million USD from the US National Institutes of Health.
[University of Melbourne] |
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| May 7 – 10, 2023
Vancouver, British Columbia, Canada |
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| | California Institute of Technology – Pasadena, California, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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