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| Epigenomic and transcriptomic analyses revealed that forkhead box protein D2 was a hub for the gene regulatory network exclusive to large intestinal stem cells, and its overexpression played a significant role in colon cancer regression.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated an inducible STN1 knockout mouse model and found that STN1 deficiency in young adult mice increased colorectal cancer incidence, tumor size, and tumor load.
[Science Advances] |
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| The authors showed that syndecan-4, a transmembrane proteoglycan, was highly expressed in intestinal subtype gastric tumors and that this signature associated with patient poor survival.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators explored the interaction between cell lines belonging to the consensus molecular subtypes (CMS) 1 and the CMS4 in a three dimensional coculture model, mimicking the intratumor heterogeneity of colorectal cancer.
[Cell Death & Disease] |
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| Scientists demonstrated that a widely used antidepressant venlafaxine antagonized norepinephrine-promoted colon cancer in vivo and in vitro.
[Cell Death Discovery] |
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| Researchers analyzed a time course of transplanted human intestinal organoid (HIOs) histologically at 2, 4, 6 and 8 weeks post-transplantation, and demonstrated that HIO maturation closely resembled key stages of fetal human intestinal development.
[Development] |
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| Scientists found that vortioxetine hydrobromide, an FDA-approved drug, was a dual tyrosine-protein kinase 2 (JAK2)/proto-oncogene tyrosine-protein kinase (SRC) inhibitor, and had inhibitory effects on cell proliferation of gastric cancer.
[Oncogenesis] |
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| Investigators revealed that the capacity of lymph node metastasis (LNM)-gastric cancer (GC)-small extracellular vesicles educating bone marrow-derived mesenchymal stem cells (BM-MSCs) was positively correlated with the LNM capacity of GC cells themselves.
[Cancer Cell International] |
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| Researchers investigated how Paeoniflorin could regulate the renewal and differentiation of intestinal stem cells to improve the regeneration and repair of the intestinal epithelium in ulcerative colitis.
[International Immunopharmacology] |
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| qRT-PCR was utilized for determining the RNU12 expression in cell lines, 113 cases of paired gastric cancer, and their adjacent normal gastric tissues.
[Scientific Reports] |
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| Scientists identified circ-METTL9, derived from 2-4 exons of METTL9 gene, might promote colorectal cancer progression by accelerating cell cycle progression.
[Carcinogenesis] |
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| The authors introduce the current procedure of scRNA-seq, and discuss the advantages and limitations of scRNA-seq. They also elaborate on the research carried out with scRNA-seq in gastric cancer in recent years.
[Frontiers In Oncology] |
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| Investigators shed light on the role of polymorphisms in mitochondrial genes as well as miRNAs regulating mitochondrial proteins in colorectal cancer initiation, progression, metastasis, and resistance to various therapies.
[Pathology – Research and Practice] |
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| DiaCarta, Ltd. announced that it has received accreditation from the College of American Pathologists for its CLIA certified lab.
[DiaCarta, Ltd.] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | KU Leuven – Leuven, Belgium |
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| | California Institute of Technology – Pasadena, California, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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