Intestinal Cell News Volume 9.18 | May 19 2023

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    Noshin Noorjahan
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    2023-05-19 | ICN 9.18


    Intestinal Cell News by STEMCELL Technologies
    Vol. 9.18 – 19 May, 2023
    TOP STORY

    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

    Scientists reported that DAB2IP was mutated or selectively silenced in the vast majority of KRAS and BRAF mutant colorectal cancers. DAB2IP loss promoted tumor development by activating wild-type H- and N-RAS proteins.
    [Cancer Research]

    Abstract
    Graphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

    To analyze responsiveness of gastric cancer to PARP inhibitor, researchers exploited a gastroesophageal adenocarcinoma platform of patient-derived xenografts (PDX) and PDX-derived primary cells and selected ten PDXs with loss-of-function mutations in homologous recombination pathway genes.
    [Cancer Research]

    Full Article

    PHGDH Preserves One-Carbon Cycle to Confer Metabolic Plasticity in Chemoresistant Gastric Cancer during Nutrient Stress

    Investigators showed that stem-like/epithelial-to-mesenchymal transition/mesenchymal (SEM)-type gastric cancer (GC) exhibited a distinct metabolic profile characterized by high glutaminase levels. SEM-type GC cells were resistant to glutaminolysis inhibition.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    A Novel EGFR Inhibitor, HNPMI Regulates Apoptosis and Oncogenesis by Modulating BCL-2/BAX and p53 in Colon Cancer

    The authors developed three potent, selective alkylaminophenols, THTMP, THMPP, and HNPMI, which were assessed for parameters including epidermal growth factor receptor (EGFR) interaction, EGFR-pathway modulation, and cytotoxic and apoptosis induction.
    [British Journal of Pharmacology]

    Abstract

    Mutational Evolution after Chemotherapy-Progression in Metastatic Colorectal Cancer Revealed by Circulating Tumor DNA Analysis

    Scientists investigated newly emerging mutations in circulating tumor DNA after disease progression in metastatic colorectal cancer (mCRC). Blood samples were prospectively collected from mCRC patients receiving palliative chemotherapy before treatment and at radiological evaluations.
    [International Journal of Cancer]

    AbstractGraphical Abstract

    SUMO1 Degrader Induces ER Stress and ROS Accumulation through deSUMOylation of TCF4 and Inhibition of Its Transcription of StarD7 in Colon Cancer

    Researchers showed that both StAR-related lipid transfer domain containing 7 (StarD7) mRNA and protein were overexpressed in human colon cancer and its knockout significantly reduced colon cancer cell growth and xenograft progression.
    [Molecular Carcinogenesis]

    Full Article

    Quaternization of High Molecular Weight Chitosan for Increasing Intestinal Drug Absorption Using Caco-2 Cells as an In Vitro Intestinal Model

    Potential use of a quaternized chitosan with 65% of 3-chloro-2-hydroxypropyltrimethylammonium as an absorptive enhancer was investigated in Caco-2 monolayers.
    [Scientific Reports]

    Full Article

    LPCAT1 Enhances the Invasion and Migration in Gastric Cancer: Based on Computational Biology Methods and In Vitro Experiments

    The protein expression and mRNA levels of lysophosphatidylcholine acyltransferase 1 (LPCAT1) were detected from in-house immunohistochemistry and public high-throughput RNA arrays and RNA sequencing.
    [Cancer Medicine]

    Full Article

    Synthesis and Cytotoxicity Assessment against Human Colorectal Cancer Cell Lines of Quaternary 8-Dichloromethyl Protoberberine Alkaloids

    Twenty-two quaternary 8-dichloromethylprotoberberine alkaloids were synthesized from premodified quaternary protoberberine alkaloids (QPAs) as substrates to improve physical and chemical properties and to obtain selectively anticancer QPA derivatives.
    [Chemistry & Biodiversity]

    Abstract
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    REVIEWS

    Maternal High-Fat Diet Increases the Susceptibility of Offspring to Colorectal Cancer via the Activation of Intestinal Inflammation

    The authors discuss the role of a high-fat diet in the pathogenesis of colorectal cancer and summarize the effects of a maternal high-fat diet on the activation of inflammation and development of colorectal cancer in offspring.
    [Frontiers in Nutrition]

    Full Article

    Oxidative Stress in the Tumor Microenvironment in Gastric Cancer and Its Potential Role in Immunotherapy

    Investigators summarize the dominant cancer immunotherapeutic strategies and describe the interaction between oxidative stress and the immune tumor microenvironment.
    [FEBS Open Bio]

    Abstract
    INDUSTRY AND POLICY NEWS

    US FDA Approves RINVOQ® (Upadacitinib) as a Once-Daily Pill for Moderately to Severely Active Crohn’s Disease in Adults

    AbbVie announced that the US FDA has approved RINVOQ® for the treatment of adults with moderately to severely active Crohn’s disease who have had an inadequate response or intolerance to one or more tumor necrosis factor blockers.
    [AbbVie]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Postdoctoral Position – Immunology

    KU Leuven – Leuven, Belgium

    Postdoctoral Fellow – Stem Cell and Regenerative Medicine

    Weill Cornell Medical College – New York, New York, United States

    Postdoctoral Positions – Celiac Disease

    California Institute of Technology – Pasadena, California, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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