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| Scientists reported that FBXW7β, a FBXW7 isoform located in the cytoplasm and frequently mutated in colorectal cancer (CRC), was an E3 ligase of fatty acid synthase (FASN). Cancer-specific FBXW7β mutations that could not degrade FASN could lead to sustained lipogenesis in CRC.
[Signal Transduction and Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established 5-fluorouracil and cisplatin resistant intestinal subtype gastric cancer patient-derived organoid lines. JAK/STAT signaling and its downstream, adenosine deaminases acting on RNA 1 (ADAR1), were shown to be concomitantly upregulated in the resistant lines.
[Nature Communications] |
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| The authors established a colon assembloid system comprising the epithelium and diverse stromal cell subtypes. These assembloids recapitulated the development of mature crypts resembling in vivo cellular diversity and organization.
[Nature Communications] |
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| Scientists used a genetic approach to determine the role of the p53/miR-34 pathway as mediator of the effects of curcumin. Three isogenic colorectal cancer cell lines rendered deficient for the p53, miR-34a, and/or miR-34b/c genes were exposed to curcumin and subjected to cell biological analyses.
[Cell Death & Differentiation] |
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| Investigators showed that PAX-interacting protein 1-antisense RNA 1 (PAXIP1-AS1) was transcriptionally repressed by homeobox D9 (HOXD9) and was significantly downregulated in gastric cancer tissues and cells.
[Cell Death & Disease] |
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| Researchers showed that procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) expression was elevated in colorectal carcinoma (CRC), and its higher expression was associated with poorer survival. Overexpression of PLOD2 also facilitated CRC proliferation, invasion, and metastasis in vitro and in vivo.
[Cancer Science] |
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| The authors discovered that the lncRNA FIT, which was downregulated in colorectal cancer (CRC) clinical samples, was transcriptionally suppressed by c-Myc in vitro and promoted CRC cell apoptosis by inducing FAS expression.
[Cancer Gene Therapy] |
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| Scientists pinpointed a representative circDYRK1A which was screened from vast amounts of public data sets using novel bioinformatics approaches together with validations from the in vitro findings.
[Scientific Reports] |
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| Researchers analyzed the expression and function of mitochondrial creatine kinase and creatine kinase B in colorectal cancer (CRC) and investigated the role of the creatine shuttle in CRC.
[Oncotarget] |
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| The authors review emerging data and correlations between CXCL12/CXCR4 axis in colorectal cancer, the implications for cancer progression, and possible therapeutic strategies that exploit this system.
[Molecular Biology Reports] |
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| James Goldenring, MD, PhD, the Paul W. Sanger Professor of Experimental Surgery at Vanderbilt University Medical Center, has been honored by the American Gastroenterological Association for making significant contributions to understanding gastrointestinal disease.
[Vanderbilt University Medical Center] |
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| June 4 – 7, 2023
Heidelberg, Germany |
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| | Wageningen University & Research – Wageningen, Netherlands |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | KU Leuven – Leuven, Belgium |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | California Institute of Technology – Pasadena, California, United States |
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