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| Scientists demonstrated that shear stress sensing regulated intestine stem cell proliferation and epithelial cell number in adult Drosophila.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that enhanced autolysosomal activity mediated by mTORC1 inhibition induced PROX1 expression and that PROX1 induction in turn inhibited NOX1-mTORC1 activation.
[Cell Reports] |
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| The authors established chronically inflamed intestinal epithelium models utilizing two-dimensional (2D) human intestinal epithelial cells and 3D human intestinal organoids in order to examine the deleterious effects of particulate matter (PM) 10 in human intestine-like in vitro models.
[Frontiers In Immunology] |
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| Side population cells were isolated from human umbilical cord mesenchymal stem cells (MSCs) and human placenta MSCs. TN+ cells and matching Tn− cells were isolated from human colorectal cancer cell lines LS174T and HT-29 by immune magnetic beads.
[Stem Cell Research & Therapy] |
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| Investigators found that methyltransferase-like 3 (METTL3) showed a positive correlation with proliferation, epithelial–mesenchymal transition, DNA repair, metastasis, and invasion in a database analysis.
[Cancer Science] |
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| The authors identified a signature of advanced colorectal cancer metastasis by performing whole genome-scale DNA methylation and full transcriptome analyses of paired primary cancers and liver metastases from colorectal cancer patients.
[iScience] |
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| Three hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and patterns of the specimens were observed in detail.
[Frontiers In Oncology] |
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| The antiproliferative effects of Calotropis procera were investigated on two cancer cell lines: HCT-116 and MCF-7. The effectiveness of the plant extract on the cytotoxicity, apoptosis, cell cycle progression, genes involved in the cell cycle, and protein expression profiles of HCT-116 and MCF-7 cells was analyzed.
[Heliyon] |
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| Researchers investigated the effects of leucine-rich repeat-containing 8 A (LRRC8A) on oxaliplatin resistance in colon cancer cells. The cell viability was measured after oxaliplatin treatment with cell counting kit-8 assay.
[Heliyon] |
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| The authors highlight current knowledge of the molecular and cellular biology of gastric adenocarcinomas, summarize the current approaches to clinical management of the disease, and consider the role of novel management and/or treatment strategies.
[Nature Reviews Clinical Oncology] |
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| Scientists address the conundrum of H. pylori-associated apoptosis and review distinct mechanisms induced in host cells that either promote or suppress apoptosis in gastric epithelial cells.
[Trends in Cancer] |
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| Investigators provide an overview of p38 and p38γ with respect to gastrointestinal cancers. Targeting p38γ is also discussed as a potential therapy for gastrointestinal cancers.
[Cancer Gene Therapy] |
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| AstraZeneca is abandoning a play for the inflammatory bowel disease market. After seeing clinical trial timelines spiral, the Anglo-Swedish drugmaker has stopped the development of a would-be rival to products sold by AbbVie and Johnson & Johnson.
[Fierce Biotech] |
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| June 6 – 9, 2023
Hinxton, England, United Kingdom |
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| | Universitätsklinikum Carl Gustav Carus Dresden – Dresden, Germany |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Wageningen University & Research – Wageningen, Netherlands |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | KU Leuven – Leuven, Belgium |
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