 | | Vol. 9.23 – 30 June, 2023 |
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| Using a single-cell RNA sequencing method, Quartz-Seq2, investigators analyzed the gene expression dynamics of progenitor cell differentiation toward pit cell, neck cell, and parietal cell lineages in healthy adult mouse corpus tissues.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a forward genetic screen, scientists found a mutation in Tvp23b, which conferred susceptibility to chemically induced and infectious colitis. Trans-Golgi apparatus membrane protein TVP23 homolog B is a transmembrane protein conserved from yeast to humans.
[Nature Communications] |
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| Researchers revealed that N4-acetylcytidine, a newly identified mRNA modification, enhanced hypoxia tolerance in gastric cancer cells by promoting glycolysis addiction. Specifically, acetyltransferase NAT10 transcription was regulated by HIF-1α, a key transcription factor of the cellular response to hypoxia.
[Advanced Science] |
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| To efficiently identify repurposed drugs for colorectal cancer (CRC), scientists developed a robust organoid-based drug screening system. By combining the repurposed drug library and computation-based drug prediction, 335 drugs were tested and 34 drugs with anti-CRC effects were identified.
[Protein & Cell] |
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| Researchers reported for the first time the oncogenic role of phosphodiesterase 4D interacting protein (PDE4DIP) in colorectal cancer growth and adaptive MEK inhibitor resistance.
[Cell Death & Disease] |
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| Scientists identified human Neuralized (NEURL), which acted as a novel tumor suppressor targeting oncogenic Wnt/β-catenin signaling in human cancers. The expression of NEURL was epigenetically regulated and markedly suppressed in human colorectal cancer.
[EMBO Reports] |
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| Investigators showed that pevonedistat blocked the ubiquitin/proteasome-dependent repair of topoisomerase I (TOP1) DNA-protein crosslinks induced by TOP1 inhibitors.
[Molecular Carcinogenesis] |
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| Investigators developed a method of culturing intestinal organoids within suspended basement membrane extract hydrogels of various geometries, which streamlines the protocol, increases the scalability, enables kinetic sampling, and improves culture uniformity without specialized equipment or additional expertise.
[Scientific Reports] |
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| Scientists characterized the dynamics of extracellular ATP (eATP) on polarized and non-polarized Caco-2 cells. eATP was quantified by luminometry using the luciferin-luciferase reaction.
[PLOS Computational Biology] |
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| Investigators elucidated the mechanisms by which miRNAs interacted with intestinal epithelial cells. First, a miRNA library of Trichinella spiralis larvae was constructed; then, based on high-throughput miRNA sequencing results, miR-153 and its predicted target genes were selected for follow-up studies.
[Veterinary Research] |
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| The authors summarize recent reports focusing on nutritional factors relevant to the development of inflammatory bowel disease (IBD) and also review data on nutritional deficiencies seen in individuals with IBD.
[Expert Review Of Gastroenterology & Hepatology] |
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| | Merck announced topline results from the Phase III KEYNOTE-585 trial, investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in combination with chemotherapy as neoadjuvant treatment, followed by adjuvant treatment with KEYTRUDA plus chemotherapy, then KEYTRUDA monotherapy.
[Merck] |
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| July 17 – 20, 2023
Burlington, Vermont, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Pfizer, Inc. – Southern California, United States |
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| | King’s College London – London, England, United Kingdom |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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