 | | Vol. 9.26 – 21 July, 2023 |
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| Scientists investigated whether sodium butyrate could protect the porcine intestinal barrier from deoxynivalenol exposure through promoting mitochondrial homeostasis.
[Journal Of Hazardous Materials] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified and characterized a novel, potentially colitogenic subset of Th17-cells in the intestine of patients with Crohn’s Disease.
[Journal Of Crohns And Colitis] |
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| Researchers demonstrated that SLIT2, an axon guidance protein, produced by CAFs and promoted gastric cancer metastasis in two gastric cancer cell lines by binding to roundabout guidance receptor 1.
[Cell Death & Disease] |
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| Scientists identified WFDC3 as a tumor suppressor that facilitates estrogen-induced inhibition of metastasis through the estrogen receptor β/TGFBR1 signaling axis. WFDC3 interacts with ERβ and increases its protein stability by inhibiting its proteasome-dependent degradation.
[Cell Death & Disease] |
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| Researchers examined if an interplay between autophagy and claudin-2 protects from colitis and associated epithelial injury. Crypt culture and intestinal epithelial cells are subjected to stress, including starvation or DSS, the chemical that induces colitis in-vivo.
[Communications Biology] |
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| Investigators studied the capability of polyelectrolytes complex nanoparticles of dermatan sulfate and chitosan, loaded with the anti-inflammatory tripeptide IRW, to sensitize colorectal cancer cells to 5-fluorouracil.
[Macromolecular Bioscience] |
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| Researchers investigated estrogen receptor (ER) α and ERβ subtypes in the regulation of estrogen-modulated colonic epithelial HCO3− and Cl− secretion and epithelial restitution.
[Journal Of Biological Chemistry] |
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| Investigators verified whether SARS-CoV-2 induced epithelial-mesenchymal transition and consequently increased the invasion potential of colon cancer cells.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
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| Scientists proposed utilizing monolayered-intestinal epithelial cells derived from human induced pluripotent stem cells instead of three-dimensional cultured intestinal organoids as a suitable tool to study SARS-CoV-2 infection.
[Scientific Reports] |
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| Researchers investigated the therapeutic effect of dauricine on ulcerative colitis. Their results indicated that dauricine attenuated the reduction of colonic length, weight loss, disease activity index, colonic tissue damage, and inflammatory cytokine levels in dextran sulfate sodium mice.
[Cell Biochemistry And Function] |
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| Given the high risk of malignancies associated with PSC-IBD, it is critical to identify patients at high risk and implement appropriate surveillance and monitoring strategies. The authors provide an overview of PSC-IBD, which exemplifies the gut–liver axis.
[Experimental & Molecular Medicine] |
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| | Zai Lab, Ltd. announced that the first patient has been treated in the mainland China portion of the global registrational, Phase III FORTITUDE-101 study for bemarituzumab, a potential first-in-class Fc-optimized monoclonal antibody that is designed to block activation of Fibroblast Growth Factor Receptor 2b.
[Zai Lab, Ltd.] |
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| August 13 – 18, 2023
Andover, New Hampshire, United States |
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| | City of Hope – Monrovia, California, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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