 | | Vol. 9.27 – 28 July, 2023 |
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| Researchers sought to determine their functional relevance by inactivating miR-34a and/or miR-34b/c using a CRISPR/Cas9 approach in the colorectal cancer cell line HCT116.
[Cell Death & Differentiation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) was found to be upregulated in colorectal cancer and significantly correlated with tumor-node-metastasis stages and survival time.
[EMBO Reports] |
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| Investigators showed that nuclear factor I B (NFIB) promoted colorectal cancer (CRC) proliferation in vitro and growth in vivo, and down-regulation of NFIB can reduce the level of nicotinamide adenine dinucleotide.
[Communications Biology] |
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| Cell anti-proliferation and mitochondrial depolarization studies on HT-29 cells suggest significantly improved chemotherapeutic efficacy of hyaluronic acid-coated irinotecan-loaded lignin nanoparticles. In vitro studies showed that nanoparticles have retained the antioxidant activity of lignin that can prevent cancer relapse.
[International Journal Of Pharmaceutics] |
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| Scientists revealed new potential roles of receptor-interacting protein kinase 1 (RIP1) in controling WNT/β-catenin canonical signaling to enhance metastasis of colorectal cancer.
[Cancer Gene Therapy] |
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| Investigators developed an enzyme-responsive injectable hydrogel to overcome the limitations of therapeutic enema. The hydrogels possessed two major advantages, which were being exploited for therapeutic drug delivery in ulcerative colitis: prolonged retention and enzyme responsiveness.
[ACS Biomaterials Science & Engineering] |
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| Researchers found that standard or high fiber diets in mice positively influenced their colonic health, whereas a high fat-high protein diet negatively influenced colonic health, consistent with clinical findings.
[Scientific Reports] |
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| The effects of knocking down ITGA7 in Caco-2/15 cells were studied using shRNA and CRISPR/Cas9 strategies. Abolition of the α7 integrin subunit resulted in a significant increase in the level of differentiation and polarization markers as well as the morphological features of intestinal cells.
[Experimental Cell Research] |
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| Scientists researched the mineral composition of Korean washed-dehydrated solar salt (WDS) without bittern. It also evaluated the anticancer effects of doenjang prepared using WDS on azoxymethane/dextran sodium sulfate–induced colon cancer in C57BL/6 mice.
[Journal Of Medicinal Food] |
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| The authors introduce the structure and composition of colonic mucus as well as its impact on the bioavailability of oral drugs and introduce various technologies used in the construction of mucus-penetrating nanomedicines.
[Expert Opinion On Drug Delivery] |
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| Telavant announced the initiation of the TAHOE study, a Phase II clinical trial of RVT-3101 for the treatment of moderate to severely active Crohn’s disease, with the first patient dosed.
[Telavant] |
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| August 25 – 28, 2023
Amsterdam, Netherlands & Virtual |
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| | Uppsala University – Uppsala, Sweden |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | City of Hope – Monrovia, California, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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