 | | Vol. 9.29 – 11 August, 2023 |
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| Investigators demonstrated that the targeting of SLC25A22 in combination with anti-PD1 therapy synergized to inhibit myeloid-derived suppressor cells and activate CD8+ T cells to suppress KRAS-mutant colorectal cancer growth in vivo.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified increased translational efficiency as a hallmark of colorectal cancer (CRC) by evaluating the transcriptomic and proteomic features of CRC patients, along with comparative transcriptomic and ribosome-protected mRNA analysis in colon epithelial cells and colon cancer cells.
[Cancer Research] |
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| Investigators demonstrated that transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) maintained intestinal barrier integrity and inactivated inflammation, and was therefore a potential therapeutic target for Crohn’s’ disease.
[BMC Medicine] |
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| Researchers elucidated the clinicopathological and molecular features of HER2-amplified and HER2-low colorectal cancers. They characterized HER2 expression statuses, focusing on their intratumoral heterogeneity and alterations in metastatic lesions to establish practical HER2 status assessments.
[British Journal Of Cancer] |
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| Scientists provided new insights into the potential mechanisms of cannabidiol-induced mutual antagonism of apoptosis and macroautophagy using wild-type, knockout and mutant human colorectal cancer cells.
[Cell Death Discovery] |
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| Using mouse models, investigators established that loss of Pkd1 greatly reduced colorectal cancer incidence and tumor growth induced by loss of the tumor suppressor Apc.
[Oncogenesis] |
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| Researchers found that LINC00665 expression was upregulated in gastric cancer (GC) than normal gastric mucosa tissues and higher LINC00665 expression is associated with a poor prognosis in GC patients. Downregulated LINC00665 inhibited GC cells proliferation, invasion, and migration in vitro.
[Cancer Gene Therapy] |
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| Investigators searched for suitable reference genes for qPCR to determine the response to radiotherapy in colorectal cancer (CRC) cell lines, organoids, and patient-derived tissues. Ten CRC cell lines and organoids were selected and irradiated based on the previous related studies conducted over the last decade.
[Scientific Reports] |
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| Researchers analyzed the correlation between human microRNA 452 and its putative target gene in human colorectal cancer cells and in mouse colitis tissues.
[Genes & Genomics] |
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| The authors introduce the concept of herbal plant-derived exosome-like nanoparticles as the active ingredient in herbal medicinal products for the treatment of inflammatory bowel disease.
[Biomedicine & Pharmacotherapy] |
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| | Bolt Biotherapeutics, Inc. announced that the first patients have been dosed in a Phase II dose-expansion clinical trial investigating BDC-1001, a HER2-targeting Boltbodyâ„¢ Immune-Stimulating Antibody Conjugate.
[Bolt Biotherapeutics, Inc.] |
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| September 20 – 23, 2023
Milan, Italy |
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| | Uppsala University – Uppsala, Sweden |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Miami – Miami, Florida, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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