 | | Vol. 9.30 – 18 August, 2023 |
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| Researchers demonstrated that invasive adenocarcinoma development in Nlrp12-deficient mice was associated with elevated expression of genes involved in proliferation, matrix degradation, and epithelial-to-mesenchymal transition.
[Journal Of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Mass spectrometry–based proteomics and phosphoproteomics were performed on 30 genomically and pharmacologically characterized metastatic colorectal cancer patient–derived xenografts to investigate the molecular basis of response to EGFR blockade and identify alternative drug targets to overcome resistance.
[Science Translational Medicine] |
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| Investigators found that RNA cytosine-C(5)-methyltransferase (NSUN2) was upregulated in gastric cancer and high NSUN2 expression was associated with poor prognosis.
[Cell Death & Disease] |
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| Researchers investigated the therapeutic potential and underlying mechanisms of fraxinellone, a degraded limonoid isolated from the root bark of Dictamnus dasycarpus, in the treatment of intestinal fibrosis.
[Acta Pharmacologica Sinica] |
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| The therapeutic effects of rutin and zinc-rutin particles were compared in dextran sulfate sodium-induced acute and chronic colitis in mice.
[Journal Of Agricultural And Food Chemistry] |
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| Scientists found and validated a mutation in delta 4-desaturase, sphingolipid 2 (Degs2) as causative in increasing susceptibility to colitis and altering the phytoceramide balance in the colon.
[Disease Models & Mechanisms] |
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| IE-6 and Caco-2 cells were used to evaluate the effect of licochalcone on apoptosis, proliferation, and migration of intestinal epithelial cells. The intestinal organoid was used to investigate ex vivo effect and mechanism of licochalcone A promoting intestinal organoid development.
[Journal Of Ethnopharmacology] |
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| Colorectal cancer cells were treated with 1 mg/mL HD–SB for 24 h, and high-throughput sequencing of circRNAs was performed.
[Scientific Reports] |
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| Since the prognostic value of ferroptosis-dependent related genes (FDRGs) in colorectal cancer (CRC) remains unclear, researchers explored the significance of FDRGs in CRC through comprehensive single-cell analysis.
[Scientific Reports] |
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| The authors provide a comprehensive overview of available clinical trials and real-world data for infliximab (IFX) subcutaneous (SC) treatment of inflammatory bowel disease, focusing on the potential benefits of switching from IFX intravenous to IFX SC.
[Expert Review Of Clinical Immunology] |
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| | Qualigen Therapeutics, Inc. announced it is partnering with Translational Drug Development (TD2) as the contract research organization to conduct the Phase I clinical development of lead drug candidate QN-302 for the treatment of advanced or metastatic solid tumors.
[Qualigen Therapeutics, Inc.] |
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| September 6 – 8, 2023
Hinxton, England, United Kingdom |
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| | Coventry University – Coventry, England, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | Cedars-Sinai – Los Angeles, California, United States |
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