 | | Vol. 9.31 – 25 August, 2023 |
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| Mass spectrometry–based proteomics and phosphoproteomics were performed on 30 genomically and pharmacologically characterized metastatic colorectal cancer patient–derived xenografts to investigate the molecular basis of response to epidermal growth factor receptor (EGFR) blockade.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Analysis of the genome-wide methylation landscape of peripheral blood mononuclear cells from colorectal cancer (CRC) patients and healthy controls by microarray, pyrosequencing, and targeted bisulfite sequencing revealed five DNA methylation markers for CRC diagnosis, especially early-stage CRC.
[Cancer Research] |
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| Researchers observed that intestinal epithelial cells treated with inhibitors of transcription or translation and human platelets maintained the capacity for hypoxia-induced glycolysis, a finding that suggested the involvement of a nontranscriptional component to the metabolic switch to a highly glycolytic phenotype.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators demonstrated that ferroptosis played a critical role in radiation-induced intestinal injury (RIII) occurrence. The RNA sequencing analysis strongly hinted ferroptosis was involved in RIII mice.
[Redox Biology] |
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| Using multi-omics studies on genetically controlled cohorts of mice, investigators identified diet as the major driver of microbial and metabolomic differences, with reductions in α diversity and widespread changes in cecal metabolites seen in high-fat diet-fed mice.
[Cell Reports] |
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| Researchers found that human epidermal growth factor receptor 2 (HER2) was present in a portion of colon cancer patients, raising the possibility of using anti-HER2 therapy. In vitro studies using colon cancer cell lines showed that RC48 effectively impeded the proliferation of HER2-positive cells.
[Cell Death & Disease] |
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| Scientists showed that mice with intestinal epithelial cell (IEC)-specific OTULIN deficiency exhibited increased susceptibility to experimental colitis and were highly sensitive to TNF toxicity, due to excessive apoptosis of OTULIN deficient IECs.
[Cell Death & Disease] |
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| Researchers reported two distinct expression patterns of achaete-scute homolog 2 (ASCL2) in proficient mismatch repair or microsatellite stable (pMMR/MSS) and dMMR/MSI-H colorectal cancers (CRCs). ASCL2 was overexpressed in pMMR/MSS CRCs and maintained a stemness phenotype.
[Oncogene] |
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| Scientists assessed the ability of caudal-type homeobox transcription factor 2 (CDX2) and mucin markers to predict prognosis and fluorouracil-based adjuvant chemotherapy benefits.
[Cancer Medicine] |
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| The authors first introduce the basic organization of the intestinal barrier and then summarize different methods to assess barrier function in vivo and ex vivo. Finally, they provide an in-depth overview of the relevance of intestinal barrier dysfunction in inflammatory bowel diseases.
[Expert Review Of Gastroenterology & Hepatology] |
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| The funding will be used for the continued development of the company and will ensure that preparations remain on track for the global Phase IIb/III IMPACT clinical development program evaluating its lead asset, S-pindolol benzoate in treating cachexia associated with non-small cell lung cancer and colorectal cancer.
[Actimed Therapeutics, Ltd.] |
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| Mainz Biomed NV announces the commercial launch of ColoAlert® in Poland, made possible through a strategic collaboration with testDNA. The partnership marks another significant step forward in providing new and innovative testing options to underserved populations in the battle against colorectal cancer.
[Mainz Biomed NV] |
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| September 20 – 23, 2023
EMBL Heidelberg and Virtual |
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| | SciLifeLab – Solna, Sweden |
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| | University of South California – Los Angeles, California, United States |
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| | Coventry University – Coventry, England, United Kingdom |
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| | Creative Biolabs – New York, New York, United States |
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| | Uppsala University – Uppsala, Sweden |
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