Intestinal Cell News Volume 9.33 | Sep 08 2023

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    2023-09-08 | ICN 9.33


    Intestinal Cell News by STEMCELL Technologies
    Vol. 9.33 – 8 September, 2023
    TOP STORY

    A Tissue-Intrinsic IL-33/EGF Circuit Promotes Epithelial Regeneration after Intestinal Injury

    Utilizing radiation injury to model intestinal pathology, scientists reported that the Interleukin-33 (IL-33)/ST2 axis, an immunomodulatory pathway monitored clinically as an intestinal injury biomarker, regulated intrinsic epithelial regeneration by inducing production of epidermal growth factor (EGF).
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Exosomal circEZH2_005, an Intestinal Injury Biomarker, Alleviates Intestinal Ischemia/Reperfusion Injury by Mediating Gprc5a Signaling

    Investigators screened the expression profile of circRNAs in intestinal tissue exosomes collected from intestinal ischemia/reperfusion mice and identified circEZH2_005 as a significantly downregulated exosomal circRNA.
    [Nature Communications]

    Full Article

    TET3-Mediated DNA Oxidation Is Essential for Intestinal Epithelial Cell Response to Stressors

    Scientists described an essential role for TET3-mediated DNA production of 5hmC to protect intestinal epithelial integrity from pathogenic infection and chemical stressors by promoting the expression of genes involved in Notch and Wnt signaling pathways.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Knockdown of ANXA10 Induces Ferroptosis by Inhibiting Autophagy-Mediated TFRC Degradation in Colorectal Cancer

    Researchers conducted transcriptome sequencing on pairs of sessile serrated lesions and corresponding normal control samples. They knocked down and overexpressed ANXA10 in colorectal cancer cells to examine its effects on cell malignant ability.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    IGF2BP3 Promotes the Progression of Colorectal Cancer and Mediates Cetuximab Resistance by Stabilizing EGFR mRNA in an m6A-Dependent Manner

    Investigators found that insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) was upregulated in CRC tissues. Clinically, the elevated IGF2BP3 level was predictive of a poor prognosis. Functionally, IGF2BP3 enhanced CRC tumorigenesis and progression both in vitro and in vivo.
    [Cell Death & Disease]

    Full Article

    Taraxacum coreanum Nakai Extract Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Intestinal Barrier Dysfunction in Caco-2 Cells

    Scientists investigated the protective effects of Taraxacum coreanum Nakai extract on inflammatory responses and intestinal barrier dysfunction in lipopolysaccharide-stimulated Caco-2 cells.
    [Journal Of Ethnopharmacology]

    Abstract

    Nrf2 Inhibition Increases Sensitivity to Chemotherapy of Colorectal Cancer by Promoting Ferroptosis and Pyroptosis

    Researchers explored the role and mechanism of Nrf2 inhibition in oxaliplatin-based chemosensitivity of colorectal cancer (CRC). In vitro, they applied 4-octyl itaconate to activate Nrf2, and used lentivirus to knock down Nrf2 in CRC cell lines.
    [Scientific Reports]

    Full Article

    Evaluation of the Risk of Diarrhea Induced by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors with Cultured Intestinal Stem Cells Originated from Crypts in Humans and Monkeys

    Investigators evaluated the risk of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-induced diarrhea using spheroids of human and monkey crypt-derived intestinal stem cells. Intestinal spheroids exhibited higher toxic susceptibility to EGFR-TKIs than Caco-2 cells.
    [Toxicology In Vitro]

    Abstract

    Tea Polyphenols Protect Bovine Intestinal Epithelial Cells from the Adverse Effects of Heat-Stress In Vitro

    Researchers investigated the protective effects of tea polyphenols against heat-stress-induced damage in bovine intestinal epithelial cells and explored the underlying mechanisms.
    [Animal Biotechnology]

    Abstract
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    REVIEWS

    Emerging Oral Drug Options for Ulcerative Colitis

    Despite the availability of a variety of therapeutic compounds and improved management strategies, one-third of ulcerative colitis patients do not benefit from the existing treatments. The authors summarize available evidence on oral drugs, which are now being explored in clinical trials.
    [Expert Opinion On Emerging Drugs]

    Abstract
    INDUSTRY AND POLICY NEWS

    Palisade Bio Transforms GI-Focused Pipeline through Exclusive Worldwide Licensing Agreement with Giiant Pharma, Inc. for Multiple Oral Drug Candidates Targeting Inflammatory Bowel Disease

    The license provides Palisade Bio with the exclusive worldwide rights to develop, manufacture, and commercialize Giiant’s proprietary targeted prodrug platform focused on therapies for the multi-billion dollar inflammatory bowel disease market.
    [Palisade Bio. Inc.]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Tumor Immunology and Immunotherapy

    October 1 – 4, 2023
    Toronto, Ontario, Canada

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    JOB OPPORTUNITIES

    PhD Studentship – AMER1 Driver Mutations in Colorectal Cancer

    University of Oxford – Oxford, England, United Kingdom

    PhD Scholarship – Crohn’s and Colitis

    University of Australia – Adelaide, South Australia, Australia

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Professor – Clinical Pediatrics

    University of South California – Los Angeles, California, United States

    PhD Studentship – Microbial Metabolites on Colorectal Cancer Cell Growth

    Coventry University – Coventry, England, United Kingdom
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