 | | Vol. 9.35 – 22 September, 2023 |
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| Scientists found that down-regulation of the conserved cholinergic enzyme acetylcholinesterase4 in the gut epithelium enables acetylcholine from specific TNF/Egr5-sensing cholinergic neurons to activate nicotinic receptors in innervated enterocytes.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified molecular drivers for metastasis and devise corresponding therapeutic strategies. They performed an unbiased in vivo genome-wide CRISPR/Cas9 knockout screening in peritoneal dissemination using genetically engineered gastric cancer mouse models.
[Molecular Cancer] |
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| In a murine model of colitis, Gal-interleukin10-extracellular vesicles alleviated inflammatory bowel disease symptoms including inflammatory responses and disrupted colonic barriers.
[Small] |
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| Investigators found that the colorectal neoplasia differentially expressed (CRNDE)/heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) axis was notably elevated in colorectal cancer and was strongly associated with poor prognosis of patients.
[Cell Death & Disease] |
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| An A. veronii strain isolated from intestinal biopsies of a patient with inflammatory bowel disease was used for pathogenic mechanism investigation, and Escherichia coli K12 was used as a bacterial control. HT-29 cells were used as a model of human intestinal epithelium.
[Microbiology Spectrum] |
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| Scientists identified TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1) and also determined that TRIM59 was a KEAP1-interacting partner protein that catalyzes its ubiquitination and degradation in intestinal epithelial cells.
[International Immunopharmacology] |
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| Researchers characterized the DNA methylation profile of metastasis-competent circulating tumor cells in colorectal cancer (CRC). The DNA methylome of the human CRC-derived cell line CTC-MCC-41 was analyzed and compared with primary and metastatic CRC cells.
[Scientific Reports] |
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| Investigators elucidated the mechanisms of mir-150–5p regulation on glucocorticoid resistance. An ulcerative colitis mouse model was used to evaluate changes in ulcerative colitis symptoms, inflammatory factors, and glucocorticoid resistance-related gene expression.
[Molecular Immunology] |
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| Scientists assessed the potential of liposomal formulations of thymoquinone and Egyptian propolis extract in combination therapy to improve their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects.
[AAPS Pharmscitech] |
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| Researchers studied the therapeutic mechanism of Liangxue-Guyuan-Yishen decoction (LGYD) on gastrointestinal acute radiation syndrome (GI-ARS) and to provide a new scheme for the treatment of radiation injury. They investigated the effects of LGYD on intestinal stem cells in a GI-ARS rat model.
[Journal Of Radiation Research] |
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| The authors summarize recent research on colitis-associated colon cancer (CAC) development and investigate the possible functions of autophagy in reducing CAC initiation.
[Autophagy] |
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| | Dr. Alexis Gibson, a postdoctoral researcher at Oregon Health & Science University, is the recipient of a 2023 Howard Hughes Medical Institute, or HHMI, Hanna Gray Fellowship. The prestigious award recognizes talented early career scientists in the biomedical sciences.
[Oregon Health & Science University] |
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| October 4 – 6, 2023
Paris, France |
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| | International PhD Programme Mainz – Mainz, Rheinland Pfalz, Germany |
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| | University of Melbourne – Melbourne, Australia |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Norwegian University of Science & Technology – Trondheim, Norway |
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| | University of Oxford – Oxford, England, United Kingdom |
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