 | | Vol. 9.36 – 29 September, 2023 |
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| Researchers uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAFs) into lipid–laden CAFs, promoting angiogenesis and tumor progression.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed an OPEN to effectively treat inflammatory bowel disease by inhibiting excessive intestianl epithelial cell apoptosis.
[Advanced Materials] |
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| Researchers suggested that activated myocardin-related transcription factor A (MRTF-A) in the intestinal epithelium shifted the balance between proliferation, differentiation, and apoptosis.
[Cell Death & Disease] |
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| Investigators examined the synergistic therapeutic impact of combining erastin with a bioactive flavonoid compound luteolin on the ferroptosis-mediated suppression of colon cancer. Human colon cancer HCT116 and SW480 cells were used for the in vitro studies and a xenograft of colon cancer model.
[Free Radical Biology And Medicine] |
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| Scientists investigated whether the combination of rosmarinic acid and ginsenoside Rg1 could exert anti-metastatic effects against colorectal cancer. MC38 tumor xenograft mouse model with lung metastasis was established.
[Acta Pharmacologica Sinica] |
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| Investigators examined the effects of SUMOylation on the expression pattern of hypoxia-inducible factor-1α (HIF-1α) in response to pan-hydroxylase inhibitor dimethyloxalylglycine in intestinal epithelial cells.
[Journal Of Biological Chemistry] |
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| Researchers investigated the clinical significance of phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) in colon adenocarcinoma (COAD) by studying its expression in 79 tissue samples using immunohistochemistry.
[Scientific Reports] |
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| Scientists investigated the association between genes associated with sphingolipid metabolism, genetic variations in colorectal cancer (CRC), and clinicopathological factors in CRC patients.
[Scientific Reports] |
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| Researchers evaluated the expression of SgK269 in colon cancer patients and explored the therapeutic effects of human amniotic mesenchymal stromal cells on the invasion and proliferation of HT-29 colon cancer cells by analyzing SgK269/c-Src/p-P130Cas/p-Paxillin/p-ERK1/2 signaling pathway.
[3 Biotech] |
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| Scientists summarize the recent developments about the critical role of intestinal epithelial cell mitochondria in actively maintaining gut microbiota, intestinal metabolism, and immune homeostasis.
[Neuroscience & Biobehavioral Reviews] |
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| The authors summarize recent research on the role and mechanism of diet in regulating intestinal stem cells and discuss the potential of dietary modulation for intestinal diseases.
[International Journal Of Food Sciences And Nutrition] |
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| Regular and intense aerobic exercise may reduce the risk of colorectal cancer in patients with Lynch Syndrome by improving the immune system’s ability to detect and remove potentially harmful cells, according to researchers at The University of Texas MD Anderson Cancer Center.
[MD Anderson Cancer Center] |
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| October 29 – November 1, 2023
New York, New York, United States |
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| | Boston Univeristy – Boston, Massachusetts, United States |
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| | The University of Tennessee – Memphis, Tennessee, United States |
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| | International PhD Programme Mainz – Mainz, Germany |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Norwegian University of Science & Technology – Trondheim, Norway |
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