Intestinal Cell News Volume 9.37 | Oct 06 2023

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    Jamie Kang
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    2023-10-06 | ICN 9.37


    Intestinal Cell News by STEMCELL Technologies
    Vol. 9.37 – 6 October, 2023
    TOP STORY

    Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis Attenuate Clinical Symptoms of Experimental Colitis by Regulating Treg/Th17 Cell Balance and Intestinal Barrier Integrity

    Signs of colonic inflammation, intestinal barrier integrity, the proportion of regulatory T cells, and the expression of pro-inflammatory and anti-inflammatory cytokines after administration of bacterial species were quantified.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    DDX5 (p68) Orchestrates β-Catenin, RelA and SP1 Mediated MGMT Gene Expression in Human Colon Cancer Cells: Implication in TMZ Chemoresistance

    Investigators uncovered an unidentified mechanism of DDX5-mediated MGMT gene regulation. Experimentally, they found that both mRNA and protein expression levels of MGMT were elevated in response to p68 overexpression in multiple human colon cancer cell lines and vice-versa.
    [Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms]

    Full Article

    MUC13 Drives Cancer Aggressiveness and Metastasis through the YAP1-Dependent Pathway

    Researchers found that MUC13 targeted a potent transcriptional coactivator, YAP1, and drove its nuclear translocation via forming a novel survival complex, which in turn augmented the levels of pro-survival and metastasis-associated genes.
    [Life Science Alliance]

    Full Article

    Loss of HES1 Expression Is Associated with Extracellular Matrix Remodeling and Tumor Immune Suppression in KRAS Mutant Colon Adenocarcinomas

    To develop a deeper understanding of the interaction between KRAS and HES1 in colorectal carcinogenesis, the authors selected microsatellite stable and KRAS mutant or KRAS wild-type colorectal cancers that show aberrant expression of HES1 by immunohistochemistry.
    [Scientific Reports]

    Full Article

    Stabilization of Cx43 mRNA via RNA-Binding Protein HuR Regulated by Polyamines Enhances Intestinal Epithelial Barrier Function

    Scientists showed that HuR is directly bound to connexin 43 (Cx43) mRNA via its 3′-untranslated region in intestinal epithelial cells and this interaction enhanced Cx43 expression by stabilizing Cx43 mRNA.
    [American Journal Of Physiology-Gastrointestinal And Liver Physiology]

    Abstract

    Phenethyl Isothiocyanate and Irinotecan Synergistically Induce Cell Apoptosis in Colon Cancer HCT 116 Cells In Vitro

    Investigators explored the apoptotic effects of the combination of irinotecan and phenethyl isothiocyanate on human colon cancer HCT 116 cells in vitro.
    [Environmental Toxicology]

    Abstract

    Aflatoxin M1 Decreases the Expression of Genes Encoding Tight Junction Proteins and Influences the Intestinal Epithelial Integrity

    Scientists evaluated the acute cytotoxic effects of aflatoxin M1 (AFM1) on intestinal Caco-2 cells. Initially, they checked the morphology and viability of Caco-2 cells after treatment with different concentrations of AFM1 for different time intervals
    [Mycotoxin Research]

    Abstract

    Exploring the Therapeutic Potential of Fe3O4@Glu-Oleuropein Nanoparticles in Targeting KRAS Pathway-Regulating lncRNAs in Colorectal Cancer Cells

    Researchers employed iron oxide nanoparticles coated with glucose and conjugated with Oleuropein (Fe3O4@Glu-Oleuropein NPs) to evaluate their impact on candidate lncRNAs associated with KRAS pathway deregulation.
    [Biological Trace Element Research]

    Abstract

    Anti-Proliferative Activity of Chitosan-Coated Oxypeucedanin Nano-Chitosomes (COPD-NCs) against Human HT-29 Colon Cancer Cells: In Vitro Study

    The anti-cancer potential of chitosan-coated oxypeucedanin nano-chitosomes (COPD-NC) was analyzed by measuring the cell survival rate and studying the cellular death type following the increased treatment concentrations of COPD-NC on the HT-29 colon cancer cell line.
    [Naunyn-Schmiedebergs Archives Of Pharmacology]

    Abstract
    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    REVIEWS

    Gastric Epithelial Stem Cells in Development, Homeostasis and Regeneration

    The authors provide an insightful synthesis of the existing knowledge on gastric epithelial stem cell biology, including the in vitro and in vivo experimental techniques that have advanced such studies.
    [Development]

    Abstract
    INDUSTRY AND POLICY NEWS

    BullFrog AI Announces Identification of Novel Potential Drug Targets for Colorectal Cancer Using Its AI-Driven bfLEAPâ„¢ Platform

    BullFrog AI Holdings, Inc. announced that it has identified multiple potential therapeutic targets, including three novel targets, for colorectal cancer using the company’s proprietary AI-driven platform, bfLEAP™.
    [BullFrog AI Holdings, Inc.]

    Press Release
    FEATURED EVENT

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    October 23 – 25, 2023
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    JOB OPPORTUNITIES

    Assistant/Associate Professor – Colorectal Surgery

    Emory University – Atlanta, Georgia, United States

    Director – Gastroenterology

    Boston Univeristy – Boston, Massachusetts, United States

    Associate Professor – Physiology

    The University of Tennessee – Memphis, Tennessee, United States

    PhD Position – B Cells in Colorectal Cancer Development and Progression

    International PhD Programme Mainz – Mainz, Germany

    Assistant Professor – Pediatric Gastroenterology

    Baylor College of Medicine – Houston, Texas, United States

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