 | | Vol. 9.38 – 13 October, 2023 |
| |
|
|
| Investigators demonstrated a novel role of claudin-2 in promoting mucosal healing in inflammatory bowel disease patients and thus regulating vulnerability to colitis severity and colitis-associated cancer, which can be exploited for improved clinical management.
[Journal Of Clinical Investigation] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers investigated the role of Drp1 in regulating glycogen metabolism in colon cancer. Knockdown of Drp1 decreases mitochondrial respiration without increasing glycolysis.
[Cell Death & Disease] |
|
|
|
| Scientists determined that miR-3913-5p was downregulated in colorectal cancer (CRC) cell lines and CRC tissues. Exogenous miR-3913-5p expression weakened the CRC cell’s growth, migration, and invasion.
[Communications Biology] |
|
|
|
| Researchers performed an integrated analysis of four RNA-Seq data sets and TCGA datasets in this study to find novel biomarkers for diagnostic, prediction, and as potential therapeutic for this malignancy, as well as to determine the molecular mechanisms of colorectal cancer carcinogenesis.
[Scientific Reports] |
|
|
|
| In vivo studies have shown that walnut protein peptides improve intestinal mucosal barrier dysfunction and reduce inflammation by inhibiting activation of the TLR4-MAPK pathway.
[Journal Of Agricultural And Food Chemistry] |
|
|
|
| Investigators explored the protective properties and potential mechanisms of wheat-germ-derived peptide APEPEPAF against ulcerative colitis. Colitis mice induced by dextran sulfate sodium were used as the animal model.
[Journal Of Agricultural And Food Chemistry] |
|
|
|
| Scientists applied structure-functional analysis to define the functional peptide of p40 that modulated the epigenetic program in intestinal epithelial cells for sustained prevention of colitis.
[Gut Microbes] |
|
|
|
| Investigators explored metabolite mimicry as an attractive strategy for the biological response to hypoxia-inducible factors (HIF). They discovered that 4-mercapto butyrate stabilized HIF more potently and had a longer biological half-life than butyrate in intestinal epithelial cells.
[Gut Microbes] |
|
|
|
| An HT-29 cell model of colitis was established by dextran sulfate sodium stimulation and cultured with lentinan and/or probiotics to examine cell proliferation and apoptosis.
[Molecular Biotechnology] |
|
|
|
|
| The authors stratify previously reported experimental and clinical observations of the role of mitochondria and intestinal microbiota in IBD.
[Journal Of Molecular Medicine] |
|
|
|
|
| Sanofi and Teva Pharmaceuticals announced a collaboration to co-develop and co-commercialize asset TEV’574, currently in Phase IIb clinical trials for the treatment of Ulcerative Colitis and Crohn’s Disease, two types of inflammatory bowel disease.
[Sanofi] |
|
|
|
|
| November 15 – 17, 2023
Seoul, Korea |
|
|
|
|
|
| | Cedars Sinai Medical Center – Los Angeles, California, United States |
|
|
|
| | Emory University – Atlanta, Georgia, United States |
|
|
|
| | University of Calgary – St. Albert, Alberta, Canada |
|
|
|
| | Boston Univeristy – Boston, Massachusetts, United States |
|
|
|
| | The University of Tennessee – Memphis, Tennessee, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
