Intestinal Cell News Volume 9.39 | Oct 20 2023

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    2023-10-19 | PULCN 12.41


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.41 – 19 October, 2023
    TOP STORY

    A Human Lung Alveolus-on-a-Chip Model of Acute Radiation-Induced Lung Injury

    A microfluidic organ-on-a-chip lined by human lung alveolar epithelium interfaced with pulmonary endothelium was used to model acute radiation-induced lung injury in vitro.
    [Nature Communications]

    Full Article
    Try proven workflows for your hPSC culture. Click to request your offer now.
    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Vesicles from Subjects with COPD Modulate Cancer Initiating Cells Phenotype through HIF-1α Shuttling

    Investigators evaluated the potential role of circulating extracellular vesicles (EVs) from COPD subjects in lung cancer onset. Plasma-EVs were isolated by ultracentrifugation from heavy smoker volunteers with or without heavy smoker-EVs, and COPD and characterized following MISEV guidelines.
    [Cell Death & Disease]

    Full Article

    Lung Stiffness of C57BL/6 versus BALB/C Mice

    Scientists determined whether a smaller lung volume or a stiffer lung tissue accounts for the greater lung elastance of C57BL/6 than BALB/c mice.
    [Scientific Reports]

    Full Article

    Role of Interleukin 6 and Its Soluble Receptor on the Diffusion Barrier Dysfunction of Alveolar Tissue

    Alveolar-like tissue was reconstructed in a microfluidic device with human microvascular lung endothelial cells cultured under flow-induced shear stress and human epithelial cells cultured at air–liquid interface.
    [Biomedical Microdevices]

    AbstractGraphical Abstract

    JMJD5 Inhibits Lung Cancer Progression by Facilitating EGFR Proteasomal Degradation

    Researchers showed that the reduced JmjC domain-containing 5 (JMJD5) expression was negatively associated with epidermal growth factor receptor stability and NSCLC progression.
    [Cell Death & Disease]

    Full Article

    PI3K/mTOR Inhibitors Promote G6PD Autophagic Degradation and Exacerbate Oxidative Stress Damage to Radiosensitize Small Cell Lung Cancer

    Investigators explored the metabolic rewiring behind radioresistance and found therapeutic approaches to overcome radioresistance. Pharmacological inhibition of PI3K/AKT/mTOR signaling improved the effectiveness of radiotherapy, including inhibiting cell proliferation and increasing cell apoptosis.
    [Cell Death & Disease]

    Full Article

    D-Mannose Induces TFE3-Dependent Lysosomal Degradation of EGFR and Inhibits the Progression of NSCLC

    Scientists reported that D-mannose up-regulated lysosomal activity by enhancing TFE3-mediated lysosomal biogenesis, thereby increasing the degradation of epidermal growth factor receptor (EGFR) and significantly down-regulating its protein level.
    [Oncogene]

    Abstract

    CEP20 Promotes Invasion and Metastasis of Non-Small Cell Lung Cancer Cells by Depolymerizing Microtubules

    Investigators demonstrated that centrosomal protein 20 (CEP20) was upregulated in NSCLC tissues and associated with cancer invasion metastasis. Notably, CEP20 depletion inhibited NSCLC cell proliferation, migration, and microtubule polymerization.
    [Scientific Reports]

    Full Article

    Phenethyl Isothiocyanate Inhibits Metastasis Potential of Non-Small Cell Lung Cancer Cells through FTO Mediated TLE1 m6A Modification

    Researchers investigated the molecular mechanisms underlying the inhibitory effects of isothiocyanates on cancer cell metastasis.
    [Acta Pharmacologica Sinica]

    Abstract
    Watch this innovation showcase from ISSCR 2021 on applications of hPSC-derived lung models.
    REVIEWS

    Alveolar Epithelial Regeneration in the Aging Lung

    The authors review emerging hypotheses that explain how the lung repairs itself after injury and why these mechanisms of lung repair fail in some individuals, particularly the elderly.
    [Journal Of Clinical Investigation]

    Full Article
    INDUSTRY AND POLICY NEWS

    European Commission Approves KEYTRUDA® (Pembrolizumab) As Adjuvant Treatment for Adults with Non-small Cell Lung Cancer at High Risk of Recurrence Following Complete Resection and Platinum-Based Chemotherapy

    Merck announced that the European Commission has approved KEYTRUDA, Merck’s anti-PD-1 therapy, as a monotherapy for the adjuvant treatment of adults with NSCLC who are at high risk of recurrence following complete resection and platinum-based chemotherapy.
    [MERCK]

    Press Release

    BU Researcher Receives Funds for AATD Research

    Andrew A. Wilson, MD, of Boston University (BU) Chobanian & Avedisian School of Medicine, has recently received a gift of $100,000 to establish the Katharine Howe Lovett Fund for Alpha-1 antitrypsin deficiency (AATD) Research.
    [Boston University]

    Press Release
    FEATURED EVENT

    AACR-KCA Joint Conference on Precision Medicine in Cancer

    November 15 – 17, 2023
    Seoul, Korea

    > See All Events

    JOB OPPORTUNITIES

    Researcher – Cystic Fibrosis

    University of Alabama at Biringham – Birmingham, Alabama, United States

    Faculty Positions – Cancer Research

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Postdoctoral Fellow – Airway Inflammation

    Institut Necker Enfants-Malades – Paris, France

    Research Positions – Pluripotent Stem Cell, Lung Differentiation, and Genomics Project

    The University of British Columbia – Vancouver, British Columbia, Canada

    Academic Physician – Sleep Medicine and/or COPD

    University of Alberta – Edmonton, Alberta, Canada

    > See All Jobs

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