 | | Vol. 9.41 – 3 November, 2023 |
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| Scientists investigated the role of interleukin (IL)-20 in inflammatory bowel disease and experimental colitis. In vivo imaging, high-resolution mini-endoscopy, and histology were used to assess intestinal inflammation.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection.
[Nature Communications] |
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| Escherichia coli strain and indole-3-lactic acid contributed to the relief of colitis by inhibiting the production of epithelial CCL2/7, thereby reducing the accumulation of inflammatory macrophages in vitro and in vivo.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists reported that chemoresistant gastric cancer cells rely heavily on endocytosis, facilitated by caveolin-1, for survival.
[Experimental & Molecular Medicine] |
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| Researchers found that salicylate induces the expression of the miR-34a and miR-34b/c genes, which encoded tumor suppressive microRNAs, in a p53-independent manner.
[Cell Death & Disease] |
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| HER-3 expression was analyzed by immunohistochemistry in two cohorts of early and advanced metastatic colorectal cancer patients.
[Cell Death Discovery] |
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| Scientists investigated the biological role of THBS2 in various types of cancers and the mechanisms underlying the malignant progression of colorectal cancer
[Cancer Cell International] |
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| Researchers demonstrated for the first time that colitis alters taste input to the brain, which could exacerbate malnutrition in inflammatory bowel disease patients.
[Scientific Reports] |
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| Investigators demonstrated a novel experimental approach, based on multi-color, fluorescent tagging of cell nuclei, in combination with picoliter droplet deposition, to study the clonal dynamics in two- and three-dimensional cell cultures.
[Scientific Reports] |
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| The authors discuss recent genetic, epigenetic, and environmental findings related to colitis-associated colorectal cancer pathogenesis in the past five years, with a focus on unbiased, high-resolution genetic profiling of non-dysplastic field cancerization in the context of inflammatory bowel disease.
[Oncogenesis] |
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| Scientists present a systematic review of studies that have tested the performance of patient-derived organoids to predict the effect of anti-cancer therapies in colorectal cancer, for chemotherapies, targeted drugs, and radiation therapy.
[Scientific Reports] |
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| Pharma Equity Group’s subsidiary, Reponex Pharmaceuticals, announced that the European Patent Office has issued an “Intention To Grant” for EU patent applications numbers 15724673.7 and 19701467.3.
[Pharma Equity Group A/S] |
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| December 2 – 6, 2023
Boston, Massachusetts, United States |
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| | Cleveland Clinic Lerner Research Institute – Cleveland, Ohio, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Boston University – Boston, Massachusetts, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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