 | | Vol. 9.42 – 10 November, 2023 |
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| To better understand the etiology of Cronkhite-Canada Syndrome, investigators generated human intestinal organoids from intestinal stem cells isolated from two patients.
[Journal Of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that CAR-like membrane protein (CLMP) was rarely mutated but significantly decreased in colorectal cancer (CRC) patients, and its deficiency accelerated CRC tumorigenesis, growth, and resistance to all-trans retinoic acid.
[Developmental Cell] |
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| Cultures of intestinal organoids revealed that IL-38 functioned as a growth factor by increasing organoid size via inducing WNT3a. In contrast, organoids from IL-38-deficient mice developed more slowly.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors reported that chemoresistant gastric cancer cells relied heavily on endocytosis, facilitated by caveolin-1, for survival.
[Experimental & Molecular Medicine] |
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| Investigators identified an exosomal lncRNA that was clinically correlated with lymph node metastasis in gastric cancer in a VEGFC-independent manner.
[Cell Death & Disease] |
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| Scientists showed that the level of Scribble was decreased in inflammatory bowel disease patients and mice with DSS-induced colitis.
[Scientific Reports] |
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| CCK8, colony formation, wound healing, and transwell assay were used to detect the effects of cell proliferation, migration, and invasion after knockdown and over expression of ADORA2A.
[Scientific Reports] |
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| Investigators showed that atovaquone could inhibit colorectal cancer metastasis and invasion in vivo and in vitro, inhibit the expression of E-cadherin protein, and promote the protein expression of N-cadherin, vimentin, ZEB1, Snail, and Slug.
[BMC Cancer] |
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| The authors found the miRNAs that modulated the expression of Tyms and Abcg2 as resistance-inducing genes in the resistant cell lines to 5-Fluorouracil.
[Heliyon] |
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| Scientists discuss the culture techniques of intestinal organoids and describe the use of intestinal organoids as research tools for intestinal diseases.
[Stem Cell Reviews and Reports] |
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| Takeda announced that the US FDA has approved FRUZAQLAâ„¢, an oral targeted therapy for adults with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if medically appropriate, an anti-EGFR therapy.
[Takeda Pharmaceutical Company Limited] |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Cleveland Clinic Lerner Research Institute – Cleveland, Ohio, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Boston University – Boston, Massachusetts, United States |
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