 | | Vol. 9.43 – 17 November, 2023 |
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| Researchers applied an integrative multi-omic strategy to systematically identify colorectal cancer dependency on non-canonical open reading frames, combining ribosome profiling and a CRISPR–Cas9 knockout screen with large-scale analysis of molecular and clinical data.
[Nature Structural & Molecular Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors provided compelling evidence demonstrating the indispensable role of epithelial miRNAs in the regeneration of the intestine in mice subjected to 5-FU or irradiation-induced injury.
[ACS Nano] |
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| Investigators reported that the expression profile of antimicrobials produced by Paneth cells was dramatically askew in human small intestinal organoids as compared to that in paired tissue from which they were derived, with a reduction of α-defensins to nearly undetectable levels.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists used a mouse model bearing pelvic colorectal cancer adjacent to the rectum and investigated the anti-cancer effects of chemically modified–miRNA143-3p lipoplexes formulated from miRNA and a cationic liposome.
[Molecular Therapy – Nucleic Acids] |
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| Researchers found that HES1 expression was significantly higher in colorectal cancer (CRC) tissues than that in adjacent normal tissues. Moreover, high HES1 expression was associated with poor survival in CRC patients.
[Cell Death Discovery] |
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| Immediately after lipopolysaccharide challenge, mitochondrial morphological destruction and dysfunction appeared in the crypt, accompanied by decreased epithelial secretion.
[Cell Cycle] |
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| Investigators showed that aberrant SET-domain-containing protein 5 (SETD5) overexpression induced stemness in colorectal cancer cells.
[Scientific Reports] |
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| The protective effect of resveratrol against fumonisin-induced intestinal toxicity was investigated by the porcine intestinal epithelial cell line.
[Environmental Toxicology] |
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| The authors investigated the effect of targeting the microRNA-148a/WNT10b axis with the long non-coding RNA LINC00261 on the proliferation and apoptosis of colorectal cancer cells.
[Heliyon] |
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| Scientists summarize recent reports on patient-derived human small intestinal and colonic organoids and highlight how these models have been used to study intestinal epithelial functions.
[European Journal Of Immunology] |
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| Biologics by McKesson has announced the US FDA approval of FRUZAQLA, an oral targeted therapy for adults with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and an anti-EGFR therapy.
[McKesson Corporation] |
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| Article-processing charges levied by publishers on authors have become an integral — and sometimes unpopular — part of the open-access revolution. Other options are being explored.
[Nature] |
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| December 4 – 7, 2023
Dublin, Ireland |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Cleveland Clinic Lerner Research Institute – Cleveland, Ohio, United States |
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