 | | Vol. 9.44 – 24 November, 2023 |
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| Researchers induced dedifferentiation of intestinal epithelial cells using Oct4, Sox2, Klf4, and c-Myc (OSKM) in vivo. The OSKM-induced forced dedifferentiation showed similar molecular features of intestinal regeneration.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported the identification of columbamine which enhanced macrophage-mediated efferocytosis and attenuated intestinal inflammation in a murine colitis model.
[EMBO Molecular Medicine] |
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| Researchers studied the interaction between nanoparticles and intestinal epithelial cells, as well as their bioeffects on downstream cells from the perspective of extracellular vesicles.
[Journal of Controlled Release] |
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| Using the TCGA public data from Pan-Cancer and the GEPIA2 platform, an in silico analysis of wt-p53 versus mut-p53 genotyped colorectal cancer patients showed that TP53 and CTNNB1 were significantly overexpressed in colorectal cancer, compared with normal tissue.
[Journal of Cell Communication and Signaling] |
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| Scientists investigated a possible mechanistic link between PAR2 activation of intracellular signaling and pro-survival events in HT29 human colon cancer cells, then identified possible strategies to restore doxorubicin effects.
[Journal of Cell Communication and Signaling] |
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| Arabinose was recognized as a significant and inherent protector of the intestinal mucosal barrier through its role in preserving the integrity of tight junctions within the intestines.
[International Immunopharmacology] |
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| Investigators identified a widespread reduction in the expression of lncRNAs including LHFPL3-AS2 in the treatment-naïve Crohn disease ileum of the RISK pediatric cohort.
[Scientific Reports] |
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| Scientists analyzed the protein levels of ZHX3 by immunohistochemistry and evaluated its relationship with the clinicopathological features and prognosis in 286 colorectal cancer patients.
[Translational Oncology] |
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| Data showed that SOX8 expression was upregulated in colorectal carcinoma (CRC) cell lines and tumor tissues. Stable knockdown of SOX8 in CRC cell lines dramatically reduced cell proliferation, migration, and invasion.
[Heliyon] |
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| Human intestinal organoids derived from pluripotent stem cells or adult stem cell biopsies represent a powerful platform to study human development, drug testing, and disease modeling in vitro, and serve as a cell source for tissue regeneration and therapeutic advances in vivo.
[Advanced Materials] |
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| Another big success for the University of Bonn in securing grants from the European Research Council (ERC), with three researchers receiving an ERC Consolidator Grant: Drs. Jan Hasenauer, Florian I. Schmidt, and Evgeny Shinder.
[University of Bonn] |
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| December 16 – 20, 2023
Waikoloa Beach, Hawaii, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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