 | | Vol. 9.46 – 8 December, 2023 |
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| Scientists showed, in three mouse models of established ulcerative colitis, that a subcutaneously injected colon-specific immunosuppressive niche reduced inflammation in the animals’ lower gastrointestinal tract.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators shed light on spatial, molecular, and functional organization of gastric mesenchyme and the spectrum of signaling sources for epithelial support.
[Nature Communications] |
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| Scientists investigated the impact of POU5F1 on the proliferation, migration, and invasion of gastric cancer cells through both in vivo and in vitro experiments.
[Cell Death & Disease] |
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| Researchers highlighted a strategy for the development of potent, biologically active Wnt signaling pathway agonists via targeting of ZNRF3.
[Cell Chemical Biology] |
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| Downregulation of programmed cell death 11 (PDCD11) greatly reduced cancer cell growth in vitro and in vivo, additionally sensitized cells to DNA damage signals, highlighting that PDCD11 was a crucial driving factor of colorectal cancerand a potential target for cancer treatment.
[Oncogenesis] |
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| Scientists investigated the role and mechanism of cancer-associated fibroblasts-derived exosomes in metastatic and chemoresistant colorectal cancer.
[Cancer Gene Therapy] |
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| Investigators explored the important effects of TRIM28 on gastric cancer (GC) and uncovered underling molecular mechanisms. They found that TRIM28 has an important influence on regulating the stem-like property of GC cell via Wnt/β-catenin signaling.
[Experimental Biology and Medicine] |
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| The effect of FENDRR on colorectal cancer was evaluated using the colony formation assay, transwell assays, and wound healing assays, and FENDRR expression was validated by qRT-PCR.
[Heliyon] |
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| Researchers explored the role of RNF183 on colon cancer (COAD). They found that RNF183 promoted COAD stemness by affecting fatty acid oxidation.
[Nutrition And Cancer-An International Journal] |
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| The author focuses on a major emerging source of nongenetic plasticity in colorectal cancer (CRC), revival stem cells. New knowledge of revival colonic stem cell plasticity in CRC provides unique opportunities to treat CRC.
[Trends in Cancer] |
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| Bristol Myers Squibb announced the Phase III CheckMate -8HW trial evaluating Opdivo plus Yervoy compared to chemotherapy for patients with microsatellite instability–high or mismatch repair deficient metastatic colorectal cancer met the dual primary endpoint of progression-free survival.
[Bristol Myers Squibb] |
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| The American Cancer Society has awarded a five-year, $1.2 million Team Science grant to a group of UNC-Chapel Hill researchers who will develop new methods to measure and map cancer screening across North Carolina.
[UNC Gillings School of Global Public Health] |
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| January 22 – 25, 2024
Santa Fe, New Mexico, United States |
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| | CharitĂ© – Universitätsmedizin Berlin – Berlin, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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