 | | Vol. 9.47 – 15 December, 2023 |
| |
|
|
| To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell fate, scientists performed a systematic single-cell analysis of 1,107 colonic organoid cultures regulated by CRC oncogenic mutations, microenvironmental fibroblasts and macrophages, stromal ligands, and signaling inhibitors.
[Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers demonstrated that the phosphorylation of SCAP by the atypical PKC, PKCλ/ι promoted its degradation and inhibited the processing and activation of SREBP2, the master regulator of cholesterol biosynthesis.
[Nature Communications] |
|
|
|
| Scientists hypothesized that butyrate would limit the epithelial mitochondrial disruption caused by E. coli-LF82. Human colonic organoids and the T84 epithelial cell line infected with E. coli-LF82 showed a significant increase in mitochondrial network fission that was reduced by butyrate co-treatment.
[Gut Microbes] |
|
|
|
| Investigators evaluated stem cell composition, autophagic vesicle content, organoid formation, and in vivo regeneration in mice with intestinal epithelial deletion of the RNA-binding protein IMP1.
[Cellular And Molecular Gastroenterology And Hepatology] |
|
|
|
| Cepharanthine (CEP) inhibited the cellular activity of gastric cancer AGS, HGC27, and MFC cell lines in this study. CEP-induced apoptosis reduced Bcl-2 expression and increased cleaved caspase 3, cleaved caspase 9, Bax, and Bad expression.
[Cell Death Discovery] |
|
|
|
| Investigators conducted comprehensive investigations utilizing human colorectal cancer HCT116 cells, human umbilical cord vascular endothelial cells, and zebrafish embryos to assess the potential benefits of DMA in suppressing tumor angiogenesis.
[Biochemical Pharmacology] |
|
|
|
| The role of miR-137-3p/miR-296-5p/ Serpin family A member 3 (SERPINA3) in CRC cell function was investigated using in vitro assays.
[BMC Medical Genomics] |
|
|
|
| Scientists investigated the role of transient receptor potential melastatin 2 (TRPM2) in acute colitis and chronic colitis-associated fibrosis progression.
[Journal Of Pharmacological Sciences] |
|
|
|
|
| The author focuses on a major emerging source of nongenetic plasticity in CRC, revival stem cells. New knowledge of revival colonic stem cell plasticity in CRC provides unique opportunities to treat CRC.
[Trends in Cancer] |
|
|
|
|
| Immuneering Corporation announced that the US FDA has cleared its Investigational New Drug (IND) application for IMM-6-415, paving the way for the company to initiate a Phase I/IIa clinical trial of this oral, twice-daily small molecule, in development for the treatment of advanced RAF or RAS mutant solid tumors.
[Immuneering Corporation] |
|
|
|
|
| January 28 – February 2, 2024
Galveston, Texas, United States |
|
|
|
|
|
| | Uppsala University – Uppsala, Sweden |
|
|
|
| | Charité – Universitätsmedizin Berlin – Berlin, Germany |
|
|
|
| | Francis Crick Institute – London, England, United Kingdom |
|
|
|
| | University of California San Francisco – San Francisco, California, United States |
|
|
|
| | BC Cancer – Vancouver, British Columbia, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
