 | | Vol. 7.23 – 25 June, 2021 |
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| Scientists mapped 3D cellular forces in mouse intestinal organoids grown on soft hydrogels and showed that these organoids exhibited a non-monotonic stress distribution that defined mechanical and functional compartments.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated intestinal epithelial cell (IEC)-specific RNA helicase DEAH-box helicase 15 (DHX15)-knockout mice and demonstrated that DHX15 was required for controlling intestinal inflammation. Mechanistically, DHX15 interacted with NLRP6 to trigger NLRP6 inflammasome assembly and activation for inducing IL-18 secretion in IECs.
[Cell Reports] |
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| MIR17HG promoted glycolysis in colorectal cancer (CRC) cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis.
[Oncogene] |
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| The authors described the role of the long non-coding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) in cancer metastasis by mechanisms related to Staufen1-mediated mRNA decay, and found that high SPRY4-IT1 expression was associated with aggressiveness and poor outcome in human colorectal, breast and ovarian cancer tissues.
[Oncogene] |
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| Scientists screened naphthalene-diimides, a class of guanine quadruplex (G4) ligands, in a cellular model of colorectal cancer, and identified the leading compound T5 with a potent and selective inhibition of cell growth by high-affinity binding to G4s in ribosomal DNA, impairing RNA polymerase I elongation.
[Cell Chemical Biology] |
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| Investigators identified PCGF1 as a crucial epigenetic regulator that sustained the stem cell-like phenotype of colorectal cancer (CRC). PCGF1 knockdown inhibited CRC stem cell proliferation and CRC stem cell enrichment.
[Cell Death & Disease] |
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| Well-established 3D organoid models of human colon and small intestine were used to characterize 5-Fluorouracil (5-FU) transcriptomic and metabolomic responses. Based on analysis of the differentially expressed genes, the most prominent molecular pathways affected by 5-FU included cell cycle, p53 signaling, mitochondrial ATP synthesis and apoptosis.
[Archives of Toxicology] |
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| The authors investigated the role nuclear receptors played in colorectal cancer (CRC) pathogenesis. Overexpression of hepatocyte nuclear factor 4 gamma (HNF4G) significantly promoted the proliferation of CRC cells in vitro.
[Cancer Gene Therapy] |
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| Researchers investigated the significance of the PD-L1/double-strand break repair pathway using samples from 17 sporadic colorectal cancer and ulcerative colitis (UC) patients with rare UC-associated dysplasia/colitic cancer cases by immunohistochemical analysis.
[Scientific Reports] |
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| Scientists developed an in vitro intestinal monolayer model using two human colonic epithelial cell lines, Caco-2 and HT-29, co-cultured in Transwell inserts and investigated the effects of heat treatment and/or hypoxia on the epithelial barrier function.
[Scientific Reports] |
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| Overexpression of Egr‑1 inhibited colon cancer cell proliferation, migration, and invasion, whereas knockdown of Egr‑1 increased colon cancer cell proliferation, migration and invasion.
[Oncology Reports] |
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| Researchers found that iron chelation decreased mitochondrial function, thereby altering nucleotide synthesis, whereas exogenous supplementation of nucleosides or aspartate partially rescued tumor growth in patient-derived enteroids and colorectal cancer cell lines in the presence of an iron chelator.
[Nature Metabolism] |
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| Investigators review the cellular communication networks in barrier tissues and the integration between tissue-resident and recruited immune cells and tissue stem cells underlying tissue adaptation to environmental stress.
[Cell] |
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| The authors discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells determine how the intestinal barrier and host-microbiota-pathogens connections are molded.
[Trends in Immunology] |
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| Scientists point out the dynamic potential of cancer stem cells and other stem cell types in colorectal cancer (CRC) treatment personalization as well as, in the improvement of current treatment approaches, opting for a higher therapeutic rate, improved prognosis, survival, and quality of life for CRC patients.
[Biomedicine & Pharmacotherapy] |
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| Amneal Pharmaceuticals, Inc. announced the US FDA has accepted for review the Biologics License Application for Bevacizumab. Amneal is seeking approval for Bevacizumab for the treatment of metastatic colorectal cancer, in combination with intravenous fluorouracil-based chemotherapy for first- or second-line treatment.
[Amneal Pharmaceuticals, Inc.] |
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| Bristol Myers Squibb announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended approval of Opdivo for the adjuvant treatment of adult patients with esophageal or gastroesophageal junction cancer who have residual pathologic disease following prior neoadjuvant chemoradiotherapy.
[Bristol Myers Squibb] |
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| July 22 – 23, 2021
Virtual |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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| | City of Hope – Monrovia, California, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | University of Maryland, College Park – College Park, Maryland, United States |
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