Mammary Cell News Volume 10.08 | Mar 1 2018

TOP STORY

c-Jun/AP-1 Overexpression Reprograms ERα Signaling Related to Tamoxifen Response in ERα-Positive Breast Cancer

Scientists showed that the AP-1 transcription factor c-Jun interacts with estrogen receptor α (ERα) and that c-Jun chromatin binding shows extensive overlap with ERα binding at the global level. [Oncogene] Abstract

(Ranked by impact factor of the journal)

BCL11B Drives Human Mammary Stem Cell Self-Renewal In Vitro by Inhibiting Basal Differentiation

The authors present a genome-scale method to discover genes driving cell-state specification. Applying this method, they identified a transcription factor, BCL11B, which drives stem cell self-renewal in vitro, by inhibiting differentiation into the basal lineage. [Stem Cell Reports] Full Article

Oncoprotein HBXIP Enhances HOXB13 Acetylation and Co-Activates HOXB13 to Confer Tamoxifen Resistance in Breast Cancer

Overexpression of HBXIP induced tamoxifen resistance in estrogen receptor positive (ER⁺) breast cancer cells. The tissue microarray analysis revealed a positive association between the expression levels of HBXIP and HOXB13 in ER⁺ breast cancer patients. HBXIP elevated HOXB13 protein level in breast cancer cells. [J Hematol Oncol] Full Article

Characterization of a Novel Breast Cancer Cell Line Derived from a Metastatic Bone Lesion of a Breast Cancer Patient

The cell line, P7731, was derived from a metastatic bone lesion of a breast cancer patient and assessed for marker expression. P7731 was analyzed for DNA copy number variation, somatic mutations, and gene expression and was compared with the primary tumor. [Breast Cancer Res Treat] Abstract

Lysine Methyltransferase SMYD2 Promotes Triple Negative Breast Cancer Progression

Silencing of SET and MYND domain 2 (SMYD2) by RNAi in triple-negative breast cancer cell lines or inhibition of SMYD2 with its specific inhibitor, AZ505, significantly reduced tumor growth in vivo. [Cell Death Dis] Full Article

A Genetic Variant in SLC30A2 Causes Breast Dysfunction during Lactation by Inducing ER Stress, Oxidative Stress and Epithelial Barrier Defects

Functional studies in vitro suggested that substitution of threonine for serine at amino acid 288 leads to hyperphosphorylation retaining ZnT2 in the endoplasmic reticulum (ER) and lysosomes, increasing ER and lysosomal zinc accumulation, ER stress, the generation of reactive oxygen species, and STAT3 activation. [Sci Rep] Full Article

MicroRNA-221 May Be Involved in Lipid Metabolism in Mammary Epithelial Cells

Through overexpression or inhibition of miR-221 expression, researchers found that it regulated lipid metabolism in mammary epithelial cells and was expressed differentially at various stages during murine mammary gland development. [Int J Biochem Cell Biol] Abstract | Graphical Abstract

Gap Junctions Contribute to Anchorage-Independent Clustering of Breast Cancer Cells

Scientists investigated the involvement of gap junction intercellular communication during anchorage-independent clustering of MCF7 breast adenocarcinoma cells. [BMC Cancer] Full Article

LncRNA HOTAIR Influences Cell Growth, Migration, Invasion, and Apoptosis via the miR-20a-5p/HMGA2 Axis in Breast Cancer

The expression levels of the lncRNA HOTAIR were upregulated in breast cancer tissues and cells. Knockdown lncRNA HOTAIR inhibited cell propagation and metastasis and facilitated cell apoptosis. [Cancer Med] Abstract | Full Article

Phosphorylation of AKT and ERK1/2 and Mutations of PIK3CA and PTEN Are Predictive of Breast Cancer Cell Sensitivity to Everolimus In Vitro

Everolimus showed a transient growth inhibition in non-tumorigenic cells, while in tumorigenic lines the drug suppressed the proliferation in a concentration-dependent manner but with different potency and efficacy, being ZR-75-1 the most sensitive and T47D the least sensitive. [Cancer Chemother Pharmacol] Abstract

A Novel Functional Crosstalk between DDR1 and the IGF Axis and Its Relevance for Breast Cancer

The authors review recent findings indicating that discoidin domain receptor 1 (DDR1) is as a novel modulator of insulin receptor (IR) and insulin-like growth factor receptor (IGF-1R) expression and function. DDR1 functionally interacts with IR and IGF-1R and enhances the biological actions of insulin, IGF-1 and IGF-2. [Cell Adh Migr] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Merrimack Doses First Patient in Randomized Phase II Clinical Study of MM-121 in Patients with Post-Menopausal Metastatic Breast Cancer

Merrimack Pharmaceuticals, Inc. announced that it has dosed the first patient in its SHERBOC study, a double-blind, placebo-controlled randomized Phase II clinical trial of MM-121 in patients with heregulin-positive, hormone receptor-positive and HER2-negative post-menopausal metastatic breast cancer. [Merrimack Pharmaceuticals, Inc.] Press Release

Lilly Receives Additional FDA Approval for Verzenio™ (Abemaciclib), as Initial Treatment for Advanced Breast Cancer

Eli Lilly and Company announced that the FDA has approved Verzenio™ in combination with an aromatase inhibitor as initial endocrine-based therapy for the treatment of postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. [Eli Lilly and Company] Press Release

EU Research Chief’s Next Act: Changing the Future of Academic Publishing

Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business] Editorial

Indian Scientist’s Sacking Spotlights Sexual Harassment

Female scientists in India hope that more academics will report sexual harassment without fear of jeopardizing their career or reputation, after a prominent biologist was sacked for allegedly harassing a staff member. [Nature News] Editorial

Here’s How the Scientists Running for Office Are Doing

They’re trained problem-solvers, but they have to learn to move beyond data to run successful campaigns. [The Atlantic] Editorial

Canadian Science Wins Billions in New Budget

Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News] Editorial

NEW Gordon Research Conferences: Cell Death
August 5-10, 2018
Newry, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Higher Scientific Officer – Breast Cancer Research (Institute of Cancer Research)

Postdoctoral Researcher – Genomic Breast Cancer Epidemiology (Karolinska Institutet)

Computational Biologist – Cancer Research (Cancer Research UK Manchester Institute)

Postdoctoral Researcher – Breast Cancer (University of Oxford)

Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai)

Postdoctoral Fellow – Cancer Research (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Clinical Bioinformatics Improving Breast Cancer Therapies (German Cancer Research Center)

Research Fellow – Breast Immunology (Dana-Farber Cancer Institute)

Postdoctoral Fellowship – Cancer Molecular Genetics and Therapeutics (Massachusetts General Cancer Center)

Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science)

Cancer Bioinformatician – Breast Cancer Research (The Institute of Cancer Research)

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