Mammary Cell News Volume 10.10 | Mar 15 2018

TOP STORY

Microenvironmental Control of Breast Cancer Subtype Elicited through Paracrine Platelet-Derived Growth Factor-CC Signaling

Investigators delineated a previously unappreciated role for cancer-associated fibroblasts (CAFs) as determinants of the molecular subtype of breast cancer. They identified paracrine crosstalk between cancer cells expressing platelet-derived growth factor-CC and CAFs expressing the cognate receptors in human basal-like mammary carcinomas. [Nat Med] Abstract | Press Release

(Ranked by impact factor of the journal)

Capture Hi-C Identifies Putative Target Genes at 33 Breast Cancer Risk Loci

The authors used capture Hi-C to annotate 63 loci; they identified 110 putative target genes at 33 loci. To assess the support for these target genes in other data sources they tested for associations between levels of expression and single nucleotide polymorphism genotype, disease-specific survival, and compared them with somatically mutated cancer genes. [Nat Commun] Full Article | Press Release

MYC-Driven Epigenetic Reprogramming Favors the Onset of Tumorigenesis by Inducing a Stem Cell-Like State

Researchers report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program, which triggers loss of cell identity and activation of oncogenic pathways. [Nat Commun] Full Article

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2⁺ Breast Cancer Subtypes

To examine how microenvironmental signals influence resistance, scientists monitored tyrosine kinase inhibitor-treated breast cancer cell lines grown on microenvironment microarrays composed of printed extracellular matrix proteins supplemented with soluble proteins. [Cell Syst] Full Article | Graphical Abstract

MicroRNA-155 Positively Regulates Glucose Metabolism via PIK3R1-FOXO3a-cMYC Axis in Breast Cancer

Investigators addressed the function of miR-155 using LC-MS/MS-based metabolic profiling of miR-155 deficient breast cancer cells. [Oncogene] Full Article

LMTK3 Confers Chemo-Resistance in Breast Cancer

Using both 2D and 3D tissue culture models, scientists found that overexpression of lemur tyrosine kinase 3 (LMTK3) decreased the sensitivity of breast cancer cell lines to cytotoxic treatment. [Oncogene] Full Article

Skp2-Dependent Reactivation of AKT Drives Resistance to PI3K Inhibitors

In a subset of triple-negative breast cancer cell lines, treatment with a phosphoinositide 3-kinase (PI3K) inhibitor or depletion of PIK3CA expression ultimately promoted AKT reactivation in a manner dependent on the E3 ubiquitin ligase Skp2, the kinases insulin-like growth factor 1 receptor and phosphoinositide-dependent kinase-1, and the cell growth and metabolism-regulating complex mechanistic target of rapamycin complex 2, but was independent of PI3K activity or phosphatidylinositol 3,4,5-trisphosphate production. [Sci Signal] Full Article

WSB-1 Regulates the Metastatic Potential of Hormone Receptor Negative Breast Cancer

High WSB1 expression was associated with decreased distant metastasis-free survival in ER-breast cancer and PR-breast cancer patients. [Br J Cancer] Abstract

B49, a BST-2-Based Peptide, Inhibits Adhesion and Growth of Breast Cancer Cells

Scientists evaluated the effect of a novel bone marrow stromal antigen (BST)-2-based peptide, B49, on adhesion and growth of breast cancer cells. Homotypic/heterotypic adhesion, three-dimensional spheroid formation, and anchorage-independent growth were used to assess the effect of B49 on cell adhesion and growth. [Sci Rep] Full Article

High Mobility Group A (HMGA) Proteins: Molecular Instigators of Breast Cancer Onset and Progression

The authors provide an overview of the pathways involved in HMGA transcriptional and post-transcriptional regulation, the utilization of HMGA as molecular markers, and the biological role of HMGA in the context of breast cancer. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Polyphor Announces Successful End of Phase I Meeting with FDA on Its Innovative Immuno-Oncology Candidate Balixafortide

Polyphor announced the successful completion of its end of Phase I meeting with the FDA for its novel immuno-oncology candidate balixafortide, a potent and highly selective antagonist of CXCR4, a G-protein coupled receptor that regulates the trafficking and homing of both cancer cells and cells of the patient’s immune system. [Polyphor] Press Release

Boehringer Ingelheim and Vanderbilt University Expand Partnership to Develop Novel Treatment Approaches for Cancer

Boehringer Ingelheim and Vanderbilt University announced the expansion of their successful existing collaboration to develop novel anti-cancer compounds. The expanded research partnership will focus on the discovery and development of new chemical therapeutics targeting the pro-survival protein MCL1 as a potential therapy against MCL1-dependent cancers. [Vanderbilt University] Press Release

‘Right-to-Try’ Bill Rejected by House, in Major Blow to GOP Efforts

In a major blow to the effort to pass a federal “right-to-try” law, House Republicans failed to muster the votes to pass a key compromise measure. [STAT News] Editorial

Springer Nature and VSNU Renew Agreement on Open Access Publishing

Springer Nature and the Association of Universities in the Netherlands (VSNU) have renewed their agreement to secure open access publishing for Dutch universities up to 2021. [The Association of Universities in the Netherlands] Editorial

Science ‘Champion’ Dan Lipinski Faces Tough Race in Illinois Primary

Representative Daniel Lipinski—an anti-abortion Democrat who voted against the Affordable Care Act and who only recently has embraced a path to citizenship for undocumented immigrants—knows that he’s out of step with progressives on many social issues. Lipinski will find out whether voters in Illinois’s third congressional district on Chicago’s southwest side feel there’s still room for him in the Democratic Party. [ScienceInsider] Editorial

NEW Gordon Research Conferences: Tissue Niches and Resident Stem Cells in Adult Epithelia
August 19-24, 2018
Waterville Valley, New Hampshire, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Cancer and RNA Biology (University of Texas)

NEW Tenure-Track Faculty Position – Pathology (McGill University)

Graduate Student – Breast and Colorectal Cancer (Dalhousie University)

Postdoctoral Researcher – Breast Cancer Biology (Karolinska Institutet)

Higher Scientific Officer – Breast Cancer Research (Institute of Cancer Research)

Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai)

Postdoctoral Fellow – Cancer Research (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellowship – Cancer Molecular Genetics and Therapeutics (Massachusetts General Cancer Center)

Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science)

Cancer Bioinformatician – Breast Cancer Research (The Institute of Cancer Research)

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