Mammary Cell News 10.12 March 29, 2018 | |
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TOP STORYFusions of lentiviral enhanced green fluorescent protein-labeled mesenchymal stroma/stem-like cells with mcherry-labeled breast epithelial cells were quantified and effects of tumor necrosis factor alpha and receptor downstream signaling were investigated. [Stem Cells] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators found for the first time that toosendanin, a triterpenoid extracted from the traditional Chinese medicine Melia toosendan Sieb et Zucc, could successfully reverse adriamycin resistance in human breast cancer cells. [Biochem Pharmacol] Abstract Vitamin C Promotes Apoptosis in Breast Cancer Cells by Increasing TRAIL Expression Researchers showed that the transcription of SVCT2, a major vitamin C transporter, was decreased in human breast cancers compared to normal breast tissues from the same patients. A decreased SVCT2 expression was also observed in breast cancer cell lines. [Sci Rep] Full Article Scientists showed that TNFα-induced cell migration and invasion involve ERK1/2-dependent up-regulation of CDKN1A/p21 expression in highly aggressive breast cancer cells and that CDKN1A/p21 plays an important regulatory role in TNFα-induced MMP9 gene expression. [Cell Signal] Abstract Investigators tested whether the strategy of knocking down delta-5-desaturase in breast cancer cells overexpressing cyclooxygenase-2 (COX-2) can also be used to promote 8-hydroxyoctanoic acid formation, thereby suppressing cancer growth, migration, and invasion. [BMC Cancer] Full Article Scientists investigated the inhibitory effect of tubeimoside V, a cyclic bisdesmoside isolated from the ethanol extracts of tubers of B. paniculatum, on anoikis resistance and the involvement of caveolin-1-related signaling pathways in such processes in MDA-MB-231 cells. [Arch Biochem Biophys] Abstract The authors decided to compare the consequences of the overexpression of HS3STs in the same cellular model. They demonstrated that, unlike HS3ST3A, the other three isozymes enhanced the proliferation of breast cancer MDA-MB-231 and BT-20 cells. [PLoS One] Full Article Na+/K+ ATPase Activity Promotes Invasion of Endocrine Resistant Breast Cancer Cells Researchers studied the effect of inhibiting Na+/K+-ATPase activity in non-tumorigenic breast cell lines and in estrogen receptor positive and negative breast cancer cells. [PLoS One] Full Article Microfibrillar-associated protein 5 (MFAP5) overexpression accelerated breast cancer cell proliferation and migration, while an opposite effect was observed when MFAP5 was knocked down. In addition, up-regulation of MFAP5 increased the expression of MMP2 and MMP9 and activated the ERK signaling pathway. [Biochem Biophys Res Commun] Abstract The unfractionated aqueous leaf extracts of O. basilicum and O. gratissimum were chemically characterized and tested for their cytotoxic, cytostatic and anti-proliferative properties against the human breast cancer cell line MCF-7. [J Bioenerg Biomembr] Abstract | |
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REVIEWSBreast Cancer Lung Metastasis: Molecular Biology and Therapeutic Implications The authors summarize the recent advances regarding the molecular signaling pathways as well as the therapeutic strategies for treating breast cancer lung metastasis. [Cancer Biol Ther] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSData on Cancer Resistance Pathway Inhibitor IT-139 to Be Presented Intezyne announced that Ayesha Shajahan-Haq, PhD, Assistant Professor of Oncology at the Georgetown Lombardi Comprehensive Cancer Center at Georgetown University, is presenting her most recent data related to IT-139’s mitigation of drug resistance in breast cancer. [Press release from Intezyne, Inc. (PR Newswire Association LLC.) discussing research to be presented at the 2018 American Association of Cancer Research (AACR) Annual Meeting, Chicago] Press Release | |
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INDUSTRY NEWSFive Prime Therapeutics, Inc. announced that it initiated patient dosing in its Phase I clinical trial of FPA150, a first-in-class immuno-oncology antibody that targets B7-H4. [Five Prime Therapeutics, Inc.] Press Release Harvard Bioengineers’ Biomaterial-Based Cancer Immunotherapies to Be Developed by Novartis The Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School of Engineering and Applied Sciences announced that Novartis will have access to commercially develop their therapeutic, biomaterial-based, cancer vaccine technology that promotes anti-cancer immunity. [Hansjörg Wyss Institute for Biologically Inspired Engineering at Harvard University] Press Release | |
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POLICY NEWSIndia Taps Biologist as New Science Adviser India has a new science adviser. Prime Minister Narendra Modi’s government tapped Krishnaswamy VijayRaghavan, a molecular biologist and head of India’s Department of Biotechnology, to fill the post. [ScienceInsider] Editorial Cambridge Analytica Controversy Must Spur Researchers to Update Data Ethics Revelations keep emerging in the Cambridge Analytica personal-data scandal, which has captured global public attention. But when the dust settles, researchers harvesting data online will face greater scrutiny. And so they should. [Nature News] Editorial Duke’s Mishandling of Misconduct Prompts New U.S. Government Grant Oversight The U.S. National Institutes of Health imposed unusual new requirements on researchers based at Duke University in Durham, North Carolina, who receive federal funds. The changes are a response to concerns over how the institution handled recent cases involving research misconduct and grant management. [ScienceInsider] Editorial Massive Cyberhack by Iran Allegedly Stole Research from 320 Universities, Governments, and Companies Nine Iranians working on behalf of the Islamic Revolutionary Guard Corps hacked the computers of 7998 professors at 320 universities around the world over the past five years, an indictment filed by a federal grand jury alleges. [ScienceInsider] Editorial
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EVENTSNEW EMBO-EMBL Symposia: Organoids: Modeling Organ Development and Disease in 3D Culture Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Associate – Stem Cell Biology (King’s College London) Postdoctoral Researcher – Breast Cancer (UT Southwestern Medical Center) Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine) Postdoctoral Training Fellow – Endocrinology (Institute of Cancer Research) Staff Position – Breast Cancer Tumor Immunology (Cleveland Clinic Taussig Cancer Institute) Research Fellow – Breast Cancer (Dana-Farber Cancer Institute) Postdoctoral Researcher – Cancer and RNA Biology (University of Texas) Tenure-Track Faculty Position – Pathology (McGill University) Graduate Student – Breast and Colorectal Cancer (Dalhousie University) Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai) Postdoctoral Fellow – Cancer Research (Memorial Sloan Kettering Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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