Mammary Cell News Volume 10.14 | Apr 12 2018

TOP STORY

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

Scientists observed a recurrent hypomethylation of 1,006 long noncoding RNA (lncRNA) genes in cancer, including epigenetically-induced lncRNA1 (EPIC1). Overexpression of EPIC1 was associated with poor prognosis in luminal B breast cancer patients and enhanced tumor growth in vitro and in vivo. [Cancer Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-Activator Complex

Investigators reported that recruitment of the JmjC-domain-containing protein 6 (JMJD6) to estrogen receptor alpha (ERα)-bound active enhancers is required for RNA polymerase II recruitment and enhancer RNA production on enhancers, resulting in transcriptional pause release of cognate estrogen target genes. [Mol Cell] Abstract | Graphical Abstract

ZMYND8 Acetylation Mediates HIF-dependent Breast Cancer Progression and Metastasis

The authors showed that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) is induced by HIF-1 and HIF-2 in breast cancer cells and also upregulated in human breast tumors, and is correlated with poor survival of patients with breast cancer. [J Clin Invest] Full Article

Characterization of PIK3CA and PIK3R1 Somatic Mutations in Chinese Breast Cancer Patients

Researchers determined that somatic mutations in phosphoinositide 3-kinase PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in Chinese breast cancer patients, with 60 novel mutations identified. [Nat Commun] Full Article

Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells

To understand the role of endogenous type I interferon (IFN-I) in spontaneous, oncogene-driven carcinogenesis, scientists characterized tumors arising in Her2/neu transgenic mice carrying a nonfunctional mutation in the IFN-I receptor. [Cancer Immunol Res] Abstract

Rab34 Regulates Adhesion, Migration, and Invasion of Breast Cancer Cells

Researchers found that Rab34 is over-expressed in aggressive breast cancer cells, implying a potential role of Rab34 in breast cancer. [Oncogene] Abstract

Polycomb Complex Protein BMI1 Confers Resistance to Tamoxifen in Estrogen Receptor Positive Breast Cancer

Investigators reported that BMI1 promotes tamoxifen resistance in estrogen receptor positive breast cancer. [Cancer Lett] Abstract

SALL1 Functions as a Tumor Suppressor in Breast Cancer by Regulating Cancer Cell Senescence and Metastasis through the NuRD Complex

The authors demonstrated that SALL1 functions as a tumor suppressor in breast cancer, which is significantly down-regulated in the basal like breast cancer and in estrogen receptor, progesterone receptor and epidermal growth factor receptor 2 triple negative breast cancer patients. [Mol Cancer] Full Article

The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells

Scientists showed that STAT3 binds directly to a regulatory region within the TNFRSF1A gene, and that TNFRSF1A levels are dependent on STAT3 function in both constitutive and cytokine-induced models of STAT3 activation. [Neoplasia] Full Article

IP₃R3 Silencing Induced Actin Cytoskeletal Reorganization Through ARHGAP18/RhoA/mDia1/FAK Pathway in Breast Cancer Cell Lines

Inositol 1,4,5-trisphosphate receptor (IP₃R) was demonstrated to be implicated in breast cancer cells migration, but its involvement in morphological changes during the migration process remains unclear. Researchers showed that IP₃R3 expression was correlated to cell morphology. [Biochim Biophys Acta] Abstract

Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis

Investigators explored the role of placental-specific protein 1 (Plac1) in cancer progression, Plac1 was reduced by RNA interference in EO771 mammary carcinoma cells. [Sci Rep] Full Article

HER2-Positive Breast Cancer: Current and New Therapeutic Strategies

The authors examine new strategies in development to treat HER2-positive metastatic breast cancer referring to the mechanisms of action of new drugs and new combinations including results reported so far. [Breast] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Puma Biotechnology and Pint Pharma Enter into Exclusive Licensing Agreement to Commercialize NERLYNX^® (Neratinib) in Latin America

Puma Biotechnology, Inc. and Pint Pharma International S.A., have entered into an agreement for Pint Pharma to commercialize NERLYNX^® in Argentina, Brazil, Chile, Colombia, Mexico and the rest of Latin America. [Puma Biotechnology, Inc.] Press Release

Susan G. Komen^® Welcomes Leaders in Health Equity, Novel Therapeutics, Bioinformatics and Advocacy to Renowned Breast Cancer Research Program

Susan G. Komen^® announced new advisory roles for 12 renowned leaders in breast cancer. These women and men will join an esteemed group of breast cancer researchers, clinicians, and advocates who help guide the organization’s education and advocacy work, public health efforts, and $956 million research program – the largest investment in breast cancer research outside of the U.S. government. [Susan G Komen] Press Release

NanoString Announces Launch of Breast Cancer 360 Research Panel, Expanding the 360 Series of Cancer Panels for Translational Research and Signature Development

NanoString Technologies, Inc. announced the launch of the Breast Cancer 360™ (BC 360) research panel. The BC 360 Panel provides a unique 360 degree view of the tumor, microenvironment and immune response. [NanoString Technologies, Inc.] Press Release

Spanish Research Gets a Nice Budget Boost—but Scientists Say It Will Be of Little Help

The Spanish government has announced plans to raise the country’s overall public R&D budget by 8.3% in 2018, from €6.5 billion to €7 billion—the biggest hike since the economic crisis hit Spain in 2008. [ScienceInsider] Editorial

Web of Science Owner Buys Tool that Offers One-Click Access to Journal Articles

The owner of the large scholarly search engine Web of Science — Clarivate Analytics — has bought a start-up company whose tool gives researchers one-click, legal access to journal articles even when off campus. [Nature News] Editorial

India Creates Unique Tiered System to Punish Plagiarism

The Indian government has adopted its first regulations on academic plagiarism—rules that some researchers say are too lenient and others fear go too far and will be difficult to implement. [ScienceInsider] Editorial

Got Data? Survey of 2017 March for Science Doesn’t Make the Grade

A group of researchers has released the first results of a large survey of those who participated in and supported last year’s March for Science. Some social scientists say the analysis is fundamentally flawed and reflects poorly on an organization that champions scientific rigor. [ScienceInsider] Editorial

Science’s Vast Gender Pay Gap Revealed in UK Wage Data

Many UK science employers pay women much less than men, and some institutions are far less equal than others, according to an analysis conducted by Nature of statistics released last week. [Nature News] Editorial

NEW 6^th Cambridge International Stem Cell Symposium
September 19-21, 2018
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Breast Cancer (Baylor College of Medicine)

NEW Senior Research Technician – Breast Cancer (Baylor College of Medicine)

NEW Research Technician – Breast Cancer (Baylor College of Medicine)

Project Manager – Breast Cancer Research (University of Cambridge)

Postdoctoral Fellow – Cancer Research (Indiana Uniersity School of Medicine)

Postdoctoral Fellows – Molecular and Translational Cancer Biology (Thomas Jefferson University)

Tenure Track Faculty Position – Cancer Research (University of Alabama at Birmingham)

Postdoctoral Research Associate – Stem Cell Biology (King’s College London)

Postdoctoral Researcher – Breast Cancer (UT Southwestern Medical Center)

Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine)

Postdoctoral Training Fellow – Endocrinology (Institute of Cancer Research)

Staff Position – Breast Cancer Tumor Immunology (Cleveland Clinic Taussig Cancer Institute)

Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

Postdoctoral Researcher – Cancer and RNA Biology (University of Texas)

Graduate Student – Breast and Colorectal Cancer (Dalhousie University)

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