Mammary Cell News Volume 10.15 | Apr 19 2018

TOP STORY

Interferon-Stimulated Genes Are Involved in Cross-Resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer

The authors investigated common features in tamoxifen-resistant and radioresistant breast cancer, since tamoxifen-resistant breast cancer cells are cross-resistant to irradiation in vitro. [Clin Cancer Res] Full Article | Abstract

(Ranked by impact factor of the journal)

ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer

Researchers identified ZRANB1 as the EZH2 deubiquitinase. ZRANB1 bound, deubiquitinated, and stabilized EZH2. Depletion of ZRANB1 in breast cancer cells resulted in EZH2 destabilization and growth inhibition. [Cell Rep] Full Article | Graphical Abstract

The miR-106b-25 Cluster Mediates Breast Tumor Initiation through Activation of NOTCH1 via Direct Repression of NEDD4L

Investigators showed that the miR-106b-25 cluster upregulates NOTCH1 in multiple breast cancer cell lines, representing both estrogen receptor and triple negative breast cancer through direct repression of the E3 ubiquitin ligase, NEDD4L. [Oncogene] Abstract

A p53/miR-30a/ZEB2 Axis Controls Triple Negative Breast Cancer Aggressiveness

Scientists identified miR-30a as a putative p53 target and observed that in breast tumors reduced miR-30a expression correlated with p53 inactivation, lymph node positivity and poor prognosis. [Cell Death Differ] Full Article

Vav1 Down‐Modulates Akt in Different Breast Cancer Subtypes: A New Promising Chance to Improve Breast Cancer Outcome

The authors demonstrated that Vav1, ectopically expressed in invasive breast tumors derived cells, down-modulates Akt acting at expression and/or activation levels depending on tumor subtype. [Mol Oncol] Full Article | Abstract

Isocitrate Dehydrogenase 1-Snail Axis Dysfunction Significantly Correlates with Breast Cancer Prognosis and Regulates Cell Invasion Ability

The clinical impact of isocitrate dehydrogenase 1 expression on the progression and prognosis of breast cancer was evaluated using immunohistochemistry assay of the corresponding tumor-adjacent normal, ductal carcinoma in situ, and invasive ductal carcinoma tissues from 309 patients with breast ductal carcinoma. [Breast Cancer Res] Full Article

Polyfluorinated Iodine Alkanes Regulated Distinct Breast Cancer Cell Progression through Binding with Estrogen Receptor Alpha or Beta Isoforms

Based on the different binding preferences of polyfluorinated iodine alkanes (PFIs) to estrogen receptor alpha and beta isoforms (ERα and β), two representative PFIs, dodecafluoro-1,6-diiodohexane and tridecafluorohexyl iodide, were selected to evaluate their effects on the proliferation of two kinds of breast cancer cells with different ERα/β expression levels, MCF-7 and T47D. [Environ Pollut] Abstract | Graphical Abstract

Ultrasound-Activated Piezoelectric Nanoparticles Inhibit Proliferation of Breast Cancer Cells

A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. [Sci Rep] Full Article

Single-Cell RNA-Seq Reveals Cell Heterogeneity and Hierarchy Within Mouse Mammary Epithelia

Researchers determined gene expression profiles of mammary epithelial cells of virgin and pregnant mice. These analyses revealed a much higher heterogeneity among the mammary cells than has been previously reported and enabled cell classification into distinct subgroups according to signature gene markers present in each group. [J Biol Chem] Full Article | Abstract

Activity of Indatuximab Ravtansine against Triple-Negative Breast Cancer in Preclinical Tumor Models

The authors showed indatuximab ravtansine as a potential mono- and combination therapy for triple-negative breast cancer. [Pharm Res] Full Article

Calmodulin Antagonist Enhances DR5‐Mediated Apoptotic Signaling in TRA‐8 Resistant Triple Negative Breast Cancer Cells

Scientists characterized the novel function of calmodulin antagonist in enhancing TRA‐8 induced cytotoxicity in TRA‐8 resistant triple negative breast cancer cells and its underlying molecular mechanisms. [J Cell Biochem] Abstract

In Vitro Cytotoxic Effect of PARP Inhibitor Alone and in Combination with Nab-Paclitaxel on Triple Negative and Luminal A Breast Cancer Cells

The in vitro cytotoxic effect of poly(ADP-ribose) polymerase (PARP) inhibitor alone and in combination with nab-paclitaxel was evaluated on human triple negative breast cancer cell line MDA-MB-231 and human luminal A breast cancer cell line MCF-7. [Oncol Rep] Abstract

PARP Inhibitors in Breast Cancer: Bringing Synthetic Lethality to the Bedside

The authors discuss current knowledge of poly(adenosine diphosphate‐ribose) polymerase (PARP) inhibitors in BRCA‐mutant breast cancer and potential future directions for these agents. [Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Effectiveness of DNAtrix Oncolytic Virus DNX-2440 Armed with OX40L to be Presented

DNAtrix, announced that DNAtrix collaborators will present results for an oncolytic virus armed with OX40 ligand (OX40L). [Press release from DNAtrix discussing research to be presented at the 2018 American Association for Cancer Research (AACR) Annual Meeting, Chicago] Press Release

Roswell Park Researchers Identify Epigenetic Changes that May Help Explain Racial Disparities in Breast Cancer

Roswell Park Comprehensive Cancer Center researchers have identified epigenetic differences in the breast cancer tumors of African-American women and women of European descent, shedding light on one mechanism by which race may influence the way breast cancer develops. [Press release from Roswell Park Comprehensive Cancer Center discussing research to be presented at the 2018 American Association for Cancer Research (AACR) Annual Meeting, Chicago] Press Release

Updated Overall Survival Data for LYNPARZA^® (Olaparib) in gBRCA-Mutated HER2-Negative Metastatic Breast Cancer Presented

AstraZeneca and Merck presented data from the Phase III OlympiAD trial showing the final overall survival results for LYNPARZA in metastatic breast cancer. [Press release from Merck discussing research presented at the 2018 American Association for Cancer Research (AACR) Annual Meeting, Chicago] Press Release

AI-Guided Cancer Therapy Platform from SRI International Identifies Novel Molecular Targets for Aggressive Form of Breast Cancer

A proprietary, precision cancer therapy platform from SRI International has identified new molecular targets for the treatment and prevention of an aggressive and difficult-to-treat type of breast cancer. Subarna Sinha, Ph.D., bioinformatics program leader at SRI, presented new data describing the platform and the validated target. [Press release from SRI International discussing research presented at the 2018 American Association for Cancer Research (AACR) Annual Meeting, Chicago] Press Release

Phoenix Molecular Designs Announces Manufacturing Collaboration with WuXi STA to Advance PMD-026 toward IND

Phoenix Molecular Designs, announced that it has entered into a collaboration with STA Pharmaceutical Co., Ltd, a WuXi AppTec group company, to manufacture the PMD-026 needed for IND-enabling toxicology studies and a Phase I study in women. [Phoenix Molecular Designs (PR Newswire Association LLC.)] Press Release

Nektar Announces Dosing of First Patient in Phase I/II Clinical Study to Evaluate Combination of TLR Agonist NKTR-262 with CD122-Biased Agonist NKTR-214 in Patients with Advanced Solid Tumors

Nektar Therapeutics announced that it has initiated dosing patients in the Phase I/II REVEAL clinical study evaluating the efficacy and safety of the combination of investigational medicines NKTR-262 and NKTR-214 in the treatment of solid tumors. [Nektar] Press Release

Novartis Appoints John Tsai Head of Global Drug Development and Chief Medical Officer

Novartis announced the appointment of John Tsai, M.D. as Head of Global Drug Development and Chief Medical Officer. [Novartis] Press Release

African Scientists Call for More Control of Their Continent’s Genomic Data

Africa-based researchers issued guidelines for the ethical handling of samples for genomic studies. The voluntary rules are an effort to combat ‘helicopter’ research, in which foreign scientists take samples and data from communities and then return to their home institutions. [Nature News] Editorial

A Final Dash across the United States: Updates from the 2018 March for Science

The March for Science celebrated its anniversary. And although the turnout around the world was significantly smaller than last year, supporters haven’t lost any of their energy. [ScienceInsider] Editorial

Spain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research

Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature News] Editorial

Panel Calls for a Postdoc Tax and Other Measures to Help Biomedical Scientists Find Jobs

The U.S. Congress, federal funding agencies, universities, and other research institutions must take significant steps, such as a postdoc “tax” and a hard cap on how long postdocs can be funded by a lab head, to better usher young biomedical scientists into viable careers, a committee from the National Academies of Sciences, Engineering, and Medicine concluded in a report. [ScienceInsider] Editorial

Dutch Universities, Journal Publishers Agree on Open-Access Deals

Despite some difficult negotiations, academic institutions in the Netherlands have been securing subscriptions that combine publishing and reading into one fee. [The Scientist] Editorial

NEW LabRoots: 2^nd Annual Cell Biology Virtual Event
September 26-27, 2018
Online

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Cancer Research (Mass General Hospital/Harvard Medical School)

NEW Postdoctoral Fellows – Breast Cancer Metastasis and RNA Regulation (Baylor College of Medicine)

NEW Postdoctoral Fellow – Breast Cancer Research (Northwestern University)

Postdoctoral Researcher – Breast Cancer (Baylor College of Medicine)

Senior Research Technician – Breast Cancer (Baylor College of Medicine)

Research Technician – Breast Cancer (Baylor College of Medicine)

Project Manager – Breast Cancer Research (University of Cambridge)

Postdoctoral Fellow – Cancer Research (Indiana Uniersity School of Medicine)

Postdoctoral Fellows – Molecular and Translational Cancer Biology (Thomas Jefferson University)

Tenure Track Faculty Position – Cancer Research (University of Alabama at Birmingham)

Postdoctoral Research Associate – Stem Cell Biology (King’s College London)

Postdoctoral Researcher – Breast Cancer (UT Southwestern Medical Center)

Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine)

Postdoctoral Training Fellow – Endocrinology (Institute of Cancer Research)

Staff Position – Breast Cancer Tumor Immunology (Cleveland Clinic Taussig Cancer Institute)

Research Fellow – Breast Cancer (Dana-Farber Cancer Institute)

Postdoctoral Researcher – Cancer and RNA Biology (University of Texas)

Graduate Student – Breast and Colorectal Cancer (Dalhousie University)

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