Mammary Cell News Volume 10.29 | Jul 26 2018

TOP STORY

MicroRNA-30 Family Members Inhibit Breast Cancer Invasion, Osteomimicry, and Bone Destruction by Directly Targeting Multiple Bone Metastasis-Associated Genes

Overexpression of miR-30 in estrogen receptor/progeterone receptor-negative breast cancer cells resulted in the reduction of bone metastasis burden in vivo. In vitro, miR-30 did not affect tumor cell proliferation, but did inhibit tumor cell invasion. [Cancer Res] Abstract

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Adam12 and lnc015192 Act as ceRNAs in Breast Cancer by Regulating miR-34a

Knockdown of Adam12 and lnc015192 inhibited breast cancer cell migration, invasion, and epithelial-mesenchymal transition. Researchers revealed that lnc015192 regulated Adam12 expression by functioning as a competing endogenous RNA (ceRNA) for miR-34a. [Oncogene] Abstract

A SIRT1-Centered Circuitry Regulates Breast Cancer Stemness and Metastasis

Scientists identified a SIRT1-PRRX1-KLF4-ALDH1 circuitry, which coupled cancer stem cells, chemo-resistance, metastasis and aging. Pro-longevity protein SIRT1 deacetylated and stabilized the epithelial-to-mesenchymal-transition inducer PRRX1, which inhibited the transcription of core stemness factor KLF4. [Oncogene] Full Article

Reciprocal Feedback Regulation of ST3GAL1 and GFRA1 Signaling in Breast Cancer Cells

Investigators found GFRA1 to be a substrate of ST3GAL1-mediated O-linked sialylation, which is crucial to GDNF-induced signaling in estrogen receptor (ER)-positive breast cancer cells. Silencing ST3GAL1 in breast cancer cells reduced GDNF-induced phosphorylation of RET, AKT and ERα, as well as GDNF-mediated cell proliferation. [Cancer Lett] Abstract

Macrophages Confer Resistance to PI3K Inhibitor GDC-0941 in Breast Cancer through the Activation of NF-κB Signaling

Using an in vitro co-culture system, researchers showed that the presence of macrophages led to the activation of NF-κB signaling in 4T1 tumor cells, rendering tumor cells resistant to PI3K inhibition by GDC-0941. [Cell Death Dis] Full Article

LncRNA MIR100HG Promotes Cell Proliferation in Triple-Negative Breast Cancer through Triplex Formation with p27 Loci

Knockdown of MIR100HG decreased cell proliferation and induced cell arrest in the G1 phase, whereas overexpression of MIR100HG significantly increased cell proliferation. MIR100HG regulated the p27 gene to control the cell cycle, and subsequently impacted the progression of triple-negative breast cancer. [Cell Death Dis] Full Article

LOC101930370/miR-1471 Axis Modulates the Hedgehog Signaling Pathway in Breast Cancer

Knockdown of LOC101930370 suppressed breast cancer cell progression. miR-1471 inhibitor resulted in a more aggressive metastasis of MCF-7 cells. Moreover, SHH and Gli-1 expression were significantly suppressed by LOC101930370 knockdown, and upregulated by miR-1471 inhibitor transfection. [Cell Physiol Biochem] Full Article

Role of Osteopontin as a Predictive Biomarker for Anti-EGFR Therapy in Triple-Negative Breast Cancer

Investigators observed that breast cancer cells engineered to overexpress osteopontin (OPN) were more sensitive to growth inhibition by erlotinib than control cells. The level of response was related to the level of OPN expression, possibly due to increased phosphorylation status of epidermal growth factor receptor (EGFR) Tyr1068. [Expert Opin Ther Targets] Abstract

KRAB-Containing Zinc Finger Protein ZNF496 Inhibits Breast Cancer Cell Proliferation by Selectively Repressing ERα Activity

Scientists reported that ZNF496, a KRAB-containing zinc finger protein family member, interacted with the DNA binding domain of estrogen receptor alpha (ERα) via its C2H2 domain. This interaction decreased ERα binding to chromatin DNA and resulted in the repression of ERα transactivation, the selective suppression of ERα target genes, and ultimately in a reduction of ERα-positive cell growth in the presence of E2. [Biochim Biophys Acta] Abstract | Graphical Abstract

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CDKN2A/P16INK4A Variants Association with Breast Cancer and Their In-Silico Analysis

The authors focus on the role of CDKN2A in breast cancer. The deletion/malfunctioning of CDKN2A in different tumors including breast cancer has recently led to the discovery of many clinical CDK inhibitors. [Breast Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Genprex Enters Agreement with the University of Texas MD Anderson Cancer Center to Study Oncoprex in Combination with Immunotherapies

Genprex, Inc. has entered a Sponsored Research Agreement with The University of Texas MD Anderson Cancer Center under which Genprex will sponsor a pre-clinical study, entitled “A Novel Therapeutic Approach for the Treatment of Cancer Using a Combination of the Multifactorial Tumor Suppressor Gene TUSC2 and Immunotherapy,” to be conducted under the direction of Jack A. Roth, MD, FACS. [Genprex] Press Release

Dr. Reddy’s Laboratories Announces the Launch of Hervycta^® (Trastuzumab Biosimilar) in India

Dr. Reddy’s Laboratories Ltd. announced that it has launched Hervycta^®, a biosimilar of Roche’s Herceptin^®, in India, indicated for the treatment of HER2-positive cancers. [Dr. Reddy’s Laboratories Ltd.] Press Release

UK-India Science Ministers Reinforce Strong Research Partnership as Future Collaboration Is Announced

The UK and Indian governments signaled their commitment to a deeper relationship by jointly announcing four new awards worth £4.8 million under the Civil Nuclear Energy program and seven new awards worth £10.8 million under Phase 2 of the Global research program on health. [GOV.UK] Editorial

University of Edinburgh Demands Retraction of Researcher’s Papers

The University of Edinburgh has asked for the retraction of five papers by cell biologist and former faculty member Irina Stancheva following an internal investigation into scientific misconduct allegations, according to Times Higher Education. [The Scientist] Editorial

New Evidence USCIS Policies Increased Denials of H-1B Visas

New data show that in 2017, U.S. Citizenship and Immigration Services (USCIS) denied many more H-1B petitions and issued numerous costly Requests for Evidence to stop highly educated foreign nationals from working in America. [Forbes Media LLC] Editorial

NEW The American Society for Cell Biology (ASCB) Annual Meeting 2018
December 8-12, 2018
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Research Assistant/Associate – Breast Cancer Therapeutics (King’s College London)

Research Assistant/Associate – Translational Breast Cancer Research (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow/Research Scientist – Breast Cancer Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Training Fellow – Breast Cancer Research (Institute of Cancer Research)

Postdoctoral Research Scientist – DNA Repair Assay, Breast Cancer (Columbia Center for Radiological Research)

Postdoctoral Position – Breast Cancer (University of Trento)

Instructor or Assistant Professor – Breast and Colon Cancer Metastasis Research (Louisiana State University Health Sciences Center)

Cancer Faculty Investigators – Basic & Translational Cancer Research (The University of Alabama)

Postdoctoral Fellow – Molecular Mechanisms of Breast & Colon Cancers (Dalhousie University)

Post-doctoral Fellow – Ovarian and Breast Cancers (John Hopkins University)

Postdoctoral Research Associate – Breast Cancer (Howard University)

Postdoctoral Fellow – Breast & Ovarian Cancer Genomics (University of Texas Health Science Center at Houston)

Postdoctoral Research Fellow – Translational Mitochondrial Research (Fred Hutch Cancer Research Center)

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