Mammary Cell News 10.43 November 1, 2018 | |
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TOP STORYRedox Regulation of EGFR Steers Migration of Hypoxic Mammary Cells towards Oxygen Scientists showed that epithelial cells from various tissues migrated with an extreme directionality towards oxygen to escape hypoxia, independently of the HIF pathway. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Collagen Prolyl 4-Hydroxylase 1 Is Essential for HIF-1α Stabilization and TNBC Chemoresistance Researchers showed that collagen prolyl 4-hydroxylase alpha 1 subunit protein expression was induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. [Nat Commun] Full Article Scientists showed that ablation of the transcription factor Foxp1 in the mammary gland profoundly impaired ductal morphogenesis, resulting in a rudimentary tree throughout life. [Dev Cell] Full Article | Press Release | Graphical Abstract TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer Investigators described the TRPS1 transcription factor as a strong breast cancer-specific hit, owing largely to lineage-restricted expression. Knockdown of TRPS1 resulted in perturbed mitosis, apoptosis, and reduced tumor growth. [Cell Rep] Full Article | Graphical Abstract The natural product cryptotanshinone was firstly remodeled and modified as a more effective STAT3 inhibitor by structure-based strategy. [Cell Death Dis] Full Article Integrin-Rac Signaling for Mammary Epithelial Stem Cell Self-Renewal Scientists demonstrated that integrins were essential for the maintenance and self-renewal of mammary epithelial stem cells. [Breast Cancer Res] Full Article TET2 Inhibits Tumorigenesis of Breast Cancer Cells by Regulating Caspase-4 Investigators found that TET2 knockout enhanced colony formation ability and in vivo tumor formation ability of MCF-7 cells, whereas TET2 depletion did not affect the growth rate of MCF-7 cells in culture. [Sci Rep] Full Article Metabotropic Glutamate Receptor-1 Regulates Inflammation in Triple Negative Breast Cancer Researchers explored a role for mGluR1 in regulating inflammation in triple negative breast cancer. GRM1 expression was silenced in MDA-MB-231 cells to study changes in expression of inflammatory genes regulated by mGluR1. [Sci Rep] Full Article Scientists aimed to determine the roles and mechanisms of long noncoding RNA (lncRNA)-cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast cancer. [J Cell Physiol] Abstract Investigators treated MCF-7, breast cancer stem cell and normal breast epithelial cell MCF10A with the BIBR1532 inhibitor. [J Cell Biochem] Abstract Data showed that SNHG20 expression was significantly upregulated, miR-495 expression was significantly downregulated, and HER2 expression was significantly upregulated in breast cancer tissues and cell lines. [J Cell Biochem] Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSMicroRNAs and Breast Cancer Stem Cells: Potential Role in Breast Cancer Therapy Scientists investigate the function and different characteristics of cancer stem cells and function of the miRNAs that are related to them. [J Cell Physiol] Abstract Long Non-Coding RNAs as Monitoring Tools and Therapeutic Targets in Breast Cancer The authors discuss the potential application of long noncoding RNAs for the monitoring and treatment of breast cancer. [Cell Oncol] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSBio-Thera Solutions, Ltd. announced the initiation of a Phase III clinical trial evaluating the efficacy and safety of its investigational HER2 Antibody-Drug Conjugate, BAT8001, in patients with HER-2 positive metastatic breast cancer who previously received trastuzumab separately or in combination with taxanes. [Bio-Thera Solutions, Ltd. (Business Wire, Inc.)] Press Release The Phase I trial will be conducted in an outpatient setting and will use intraventricular delivery of chimeric antigen receptor (CAR) T cells directly to the brains of patients. [City of Hope] Press Release | |
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POLICY NEWSWhat Will a New California Law Mean for Biotech? Hundreds More Women in the Boardroom In the next few years, publicly traded life sciences companies headquartered in California could collectively need to add hundreds of women to their boards in order to comply with a new state gender-parity law. That’s going to mean finding women to fill 126 board seats in the sector by the end of 2019. [STAT News] Editorial Research Is Often Unpaid in Sub-Saharan Africa Unpaid research stints are the norm for scientists in sub-Saharan Africa, according to an online survey of 412 academics that spanned six countries. Eighty-five per cent of respondents report having had research positions with no pay. Of those, 33% had spent between one and five years doing research for free, and 4% had spent more than five years doing so. [Nature News] Editorial
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EVENTSNEW 15th Annual Stem Cell Symposium: Stem Cells B2B – Bench to Bedside Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Senior Coordinator, Clinical Studies – Breast Medical Oncology (MD Anderson Cancer Center) NEW Research Assistant – Breast Medical Oncology (MD Anderson Cancer Center) NEW Faculty Position – Cancer Pathobiology (University of Alabama at Birmingham) Researcher Positions – Cancer (University of Bergen) Research Fellow – Immunology (King’s College London) Postdoctoral Position – Novel Cancer Gene and Therapy (University of Notre Dame) Research Associate – Immunology (King’s College London) Research Associate – CAR T-Cell Immunotherapy (King’s College London) Postdoctoral Fellowship – Epigenetics and RNA Biology (UmeÃ¥ University) Postdoctoral Research Fellow – Mammary Stem Cell Biology (University of Southampton) Assistant/Associate/Professor – Department of Cancer Biology (University of Cincinnati) Postdoctoral Fellow – Stem Cells and Cancer (Albert Einstein College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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