Mammary Cell News 10.45 November 15, 2018 | |
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TOP STORYThe Critical Role of AMPK in Driving Akt Activation under Stress, Tumorigenesis and Drug Resistance AMPK-mediated Skp2 S256 phosphorylation promoted breast cancer progression in mouse tumor models, correlated with Akt and AMPK activation in breast cancer patients, and predicted poor survival outcomes. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Targeting 17q23 Amplicon to Overcome the Resistance to Anti-HER2 Therapy in HER2+ Breast Cancer 17q23 amplification resulted in aberrant expression of WIP1 and miR-21, which not only promoted breast tumorigenesis, but also led to resistance to anti-HER2 therapies. Inhibiting WIP1 and miR-21 selectively inhibited the proliferation, survival and tumorigenic potential of the HER2+ breast cancer cells harboring 17q23 amplification. [Nat Commun] Full Article Estrogen-Dependent DLL1-Mediated Notch Signaling Promotes Luminal Breast Cancer Researchers showed that DLL1, a Notch signaling ligand, was significantly overexpressed in ERα+ luminal breast cancer. [Oncogene] Full Article Scientists found that CtBP regulated intracellular cholesterol homeostasis in breast cancer cells by forming a complex with ZEB1 and transcriptionally repressing SREBF2 expression. [Oncogene] Abstract Investigators showed that PARP3 knockdown exacerbated centrosome amplification and genome instability and reduced survival of BRCA1-deficient triple-negative breast cancer cells. [Cell Death Differ] Abstract Investigators tested the mutagenicity of long-term treatment with the PARP inhibitor niraparib using whole-genome sequencing of cultured cell clones and whole-exome sequencing of patient-derived breast cancer xenografts. [Br J Cancer] Full Article Researchers investigated whether estrogen receptor-α and progesterone receptor-B interactions were present in breast tumors and associated with clinical parameters including response to aromatase inhibitors. [Br J Cancer] Abstract Ribosomal Protein S27-Like Regulates Autophagy via the β-TrCP-DEPTOR-mTORC1 Axis Scientists reported that ribosomal protein S27-like silencing significantly induced autophagy in breast cancer MB231 and SK-BR3 cells harboring mutant p53. [Cell Death Dis] Full Article Researchers explored the role of enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 (PFKFB4) in tumor metastasis and its underlying mechanisms in breast cancer cells. [Cell Physiol Biochem] Full Article ME1 Promotes Basal-Like Breast Cancer Progression and Associates with Poor Prognosis Scientists showed that malic enzyme 1 (ME1) was dramatically upregulated in basal-like breast cancer due to ME1 copy number amplification. [Sci Rep] Full Article Investigators used MDA-MB-231 and MCF7 breast cancer cell lines to explore the role of leucine aminopeptidase 3 in the regulation of cancer cell migration and invasion. [J Cell Biochem] Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSRecent Advances in Breast Cancer Research Impacting Clinical Diagnostic Practice The latest information on clinical trials and implementation of gene-based diagnostics is synthesized, and emerging targeted therapies as well as the burgeoning immuno-oncology field, and their relevance in breast cancer, are discussed. [J Pathol] Abstract Key MicroRNAs in the Biology of Breast Cancer; Emerging Evidence in the Last Decade The authors focus on recent findings on the involvement of miRNAs in the biology of breast cancer associated with their clinical implications. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSOncoSec To Present Data in Late-Stage Triple Negative Breast Cancer OncoSec Medical Inc. announced that TAVOâ„¢ will be featured in two poster sessions. Posters include data on TAVOâ„¢ as a monotherapy and an initial project overview for KEYNOTE-890, a Phase II clinical trial in combination with Merck’s pembrolizumab for the treatment of late stage triple negative breast cancer. [Press release from OncoSec Medical Inc. discussing research presented at the San Antonio Breast Cancer Symposium, San Antonio] Press Release | |
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INDUSTRY NEWSBreast Cancer Research Foundation Funds 8 Fred Hutch/UW Cancer Consortium Scientists Eight researchers in the Fred Hutchinson/University of Washington Cancer Consortium have received grants totaling nearly $2 million from the Breast Cancer Research Foundation, funding that will continue to fuel their research through 2019. Most of the grants will go toward new therapies for patients with metastatic cancers. [Fred Hutchinson Cancer Research Center] Press Release Pittsburgh Researchers Awarded $1M Grant for Breast Cancer Research Four UPMC Hillman Cancer Center and University of Pittsburgh researchers have received a $1 million grant for breast cancer research. The grant is part of a $63 million investment in cancer research by the Breast Cancer Research Foundation. The money will be used for all areas of breast cancer research, from the most basic biology of a cancer cell to developing innovative new treatments and improving quality of life. [University of Pittsburgh] Press Release | |
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POLICY NEWSBrexit: What the Draft Deal Means for Science On 14 November, the Cabinet, the UK government’s senior decision-making body, backed a draft agreement on the terms of the country’s withdrawal from the European Union. For science, many of the details that will be most relevant are still to be thrashed out. [Nature News] Editorial How Facebook and Twitter Could Be the Next Disruptive Force in Clinical Trials Participants in medical research are more empowered than ever to influence the design and outcomes of experiments. Now, researchers are trying to keep up. [Nature News] Editorial
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EVENTSNEW Cellular Signaling and the Environment in Mammary Gland Development in Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Molecular and Cell Biology (Baylor College of Medicine) NEW Research Assistant – Breast Medical Oncology (MD Anderson Cancer Center) Senior Coordinator, Clinical Studies – Breast Medical Oncology (MD Anderson Cancer Center) Research Assistant – Breast Medical Oncology (MD Anderson Cancer Center) Faculty Position – Cancer Pathobiology (University of Alabama at Birmingham) Researcher Positions – Cancer (University of Bergen) Research Fellow – Immunology (King’s College London) Postdoctoral Position – Novel Cancer Gene and Therapy (University of Notre Dame) Research Associate – Immunology (King’s College London) Postdoctoral Fellowship – Epigenetics and RNA Biology (UmeÃ¥ University) Assistant/Associate/Professor – Department of Cancer Biology (University of Cincinnati) Postdoctoral Fellow – Stem Cells and Cancer (Albert Einstein College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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