Mammary Cell News 11.02 January 24, 2019 | |
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TOP STORYA Recombinant Human Protein Targeting HER2 Overcomes Drug Resistance in HER2-Positive Breast Cancer Researchers showed that PEPDG278D was highly active in preclinical models of human epidermal growth factor receptor 2 (HER2)-positive breast cancer resistant to trastuzumab and other HER2 inhibitors and also enhanced the therapeutic efficacy of paclitaxel. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Iterative mouse modeling and comparative oncogenomics analysis showed that MYC-overexpression strongly reshaped the copy-number alteration landscape of BRCA1-deficient mammary tumors and identified MCL1 as a collaborating driver in these tumors. [Nat Commun] Full Article High resolution mapping of the lipophilic osmocenyl-tamoxifen in cells revealed its preferential accumulation in the endomembrane system encompassing endoplasmic reticulum, nuclear envelope and vesicular structures. [Angew Chem Int Ed Engl] Abstract MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ The MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1)/NODAL axis promoted cancer stem cell properties and invasion in vitro. The MNK1/2 inhibitor SEL201 blocked ductal carcinoma in situ progression to invasive disease in vivo. [Cancer Res] Abstract | Full Article Splicing Factor ESRP1 Controls ER-Positive Breast Cancer by Altering Metabolic Pathways Scientists reported that high levels of epithelial splicing regulatory proteins 1 (ESRP1), but not ESRP2, were associated with poor prognosis in estrogen receptor (ER) positive breast tumors. [EMBO Rep] Abstract | Graphical Abstract Stable overexpression of PAK1S204A in breast cancer cells impeded migration, invasion, and NFĸB activity. In vivo breast cancer cell tumorigenesis was significantly reduced in tumors expressing PAK1S204A mutant. [Oncogene] Abstract Leptin sensitized non-neoplastic cells to proliferative stimuli, caused mitotic spindle misalignment, and expanded the pool of cells with stem/progenitor characteristics, which are early steps for cancer initiation. [Oncogene] Abstract Investigators found a specific signature of persistently phosphorylated tyrosine peptides after nonapoptotic treatments, which they used to distinguish between different treatment-induced cancer cell fates. [Sci Signal] Abstract Elevated Expression of Gab1 Promotes Breast Cancer Metastasis by Dissociating the PAR Complex In breast cancer cell line MDA-MB-231 and SK-BR3 cells, stable overexpression of Grb2-associated binding protein 1 (Gab1) promoted, while knockdown of Gab1 inhibited cell migration in vitro and metastasis in vivo. [J Exp Clin Cancer Res] Full Article Expression levels of anterior gradient 2 (AGR2) and miR-135b-5p were analyzed in different breast cancer cell lines as well as in clinical breast cancer tissues. The in vitro and in vivo functional effect of AGR2 and miR-135b-5p were also investigated. [J Exp Clin Cancer Res] Full Article Circular RNA hsa_circ_001783 Regulates Breast Cancer Progression via Sponging miR-200c-3p Researchers systematically analyzed the circular RNAs (circRNAs) in breast cancer based on their characteristic in sponging disease-specific miRNAs and identified hsa_circ_001783 as a top ranked circRNA in their computation and verified its high expression in both breast cancer cells and cancer tissue. [Cell Death Dis] Full Article Varlitinib inhibited HER signaling which led to inhibition of migration, invasion and mammosphere formation of triple-negative breast cancer cells as well as significant suppression of tumor growth in a MDA-MB-468 xenograft mouse model. [Cancers] Abstract | Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSBreast Cancer Treatment: A Review The authors focus on current approaches and evolving strategies for local and systemic therapy of breast cancer. [JAMA] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSPharmacy Times Continuing Education™ Presents a Live Virtual Symposium on Breast Cancer Pharmacy Times Continuing Education™ will host the virtual symposium Pharmacists Reaching Out®: Optimizing Patient Management in HR+, HER2- Advanced Breast Cancer: Focus on CDK4/6 Inhibitors. [Press release from Pharmacy Times Office of Continuing Professional Education, LLC. (Business Wire, Inc.) discussing research to be presented at the Pharmacists Reaching Out Virtual Symposium] Press Release | |
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INDUSTRY NEWSSTEMCELL Technologies has released mTeSRâ„¢ Plus, an enhanced version of mTeSRâ„¢1, the most widely published feeder-free human pluripotent stem cell maintenance medium. The new medium has undergone successful beta testing with several members of the Stem Cell COREdinates group and has completed rigorous in-house validation testing. [STEMCELL Technologies Inc.] Press Release Samsung Bioepis Co., Ltd. announced that the FDA has approved trastuzumab-dttb, a biosimilar referencing trastuzumab, across all eligible indications, namely adjuvant treatment of HER2-overexpressing breast cancer, metastatic breast cancer and metastatic gastric cancer or gastroesophageal junction adenocarcinoma in patients who have not received prior treatment for metastatic disease. [Samsung Bioepis Co., Ltd.] Press Release | |
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POLICY NEWSBrazil’s New President Has Scientists Worried. Here’s Why Brazil has long been a frontrunner in climate change policy and environmental diplomacy. The international conventions on climate change and biological diversity, for example, were born during the historic United Nations Earth Summit in Rio de Janeiro in 1992, and Brazil played a key role in crafting and implementing both agreements. That legacy is now at risk. [Science Insider] Editorial Number of EU Research Students in Britain Drops from Pre-Referendum High The number of postgraduate researchers at UK universities who come from other European Union countries has fallen since the Brexit referendum in June 2016. [Nature News] Editorial CRISPR-Baby Scientist Fired by University The scientist who announced last year that he had produced the world’s first gene-edited babies has been fired by his university. [Nature News] Editorial
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EVENTSNEW The NYSCF Conference 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Breast Cancer (The Royal College of Surgeons in Ireland) NEW Research Fellowship – Cancer Biology (University of Dundee) Postdoctoral Fellowship – Breast Cancer (Cold Spring Harbor Laboratory) Postdoctoral Fellowship – Cancer Research (North Carolina Central University) Postdoctoral Fellowship – Breast Cancer (University of Bergen) Postdoctoral Fellow – Breast Cancer Research (City of Hope) Faculty Position – Molecular Cancer Biology (University of Pittsburgh) Faculty Position – Breast Cancer (University of Texas MD Anderson Cancer Center) Postdoctoral Associate – Cancer (University of Miami) Postdoctoral Position – Breast Cancer (Northwestern University) Research Associate – Breast Single Cell Atlas (University of Cambridge) Research Assistant – Breast Medical Oncology (University of Texas MD Anderson Cancer Center) Associate Researcher – Breast Cancer Biology (Icahn School of Medicine at Mount Sinai) Master’s Student – Stem Cell Biology and Cancer (Helmholtz-Center München) Postdoctoral Position – Novel Cancer Gene and Therapy (University of Notre Dame) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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