Mammary Cell News 11.03 January 31, 2019 | |
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TOP STORYAll palbociclib-sensitive cell-lines showed decreased [18F]FLT-accumulation and S-phase depletion after treatment, with both measures augmented by combination-therapy. In contrast, these cells showed changes in [18F]ISO-1 analogue-binding and G0 arrest only after prolonged treatment. [Clin Cancer Res] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The Circular RNome of Primary Breast Cancer Researchers identified circular RNA (circRNA) profiles associated with subgroups of breast cancers and with biological and clinical features such as amount of tumor lymphocytic infiltrate and proliferation index. siRNA-mediated knockdown of circCNOT2 was shown to significantly reduce viability of breast cancer cell lines MCF-7 and BT-474. [Genome Res] Abstract Afadin Cooperates with Claudin-2 to Promote Breast Cancer Metastasis Scientists examined the role of afadin as a potential claudin-2-interacting partner that promoted breast cancer liver metastasis. Afadin associated with claudin-2, an interaction that required the PDZ-binding motif of claudin-2. Loss of afadin also impaired the ability of breast cancer cells to form colonies in soft agar and metastasize to the lungs or liver. [Genes Dev] Abstract | Full Article Investigators challenged peptide-loaded MCF-7 breast cancer cells with antigen-specific CD8+ T cells in which lytic granules had been destroyed by pre-treatment with concanamycin A. Gene expression analysis after co-culture revealed simultaneous induction of PD-L1, IDO1, CEACAM1, and further immunoregulatory checkpoints in breast cancer cells. [Cancer Res] Abstract Glutathione S-transferases P1 protein level was very low in human breast cancer cell line MCF-7 but was high in adriamycin (ADR)-resistant MCF-7/ADR cells. Under ADR treatment, MCF-7/ADR cells showed a higher autophagy level than MCF-7 cells. [Cell Death Differ] Abstract The authors reported that human triple-negative breast cancers molecularly stratified for high levels of programmed death-1 (PD-1)/PD-1 ligand (PD-L1) showed significantly enriched expression of immune and cancer stemness pathways compared with those with low PD-L1 expression. [Oncogene] Full Article The Arginine Methyltransferase PRMT1 Regulates IGF-1 Signaling in Breast Cancer Researchers found that IGF-1 treatment of MCF-7 cells induced rapid ERα methylation by the arginine methyltransferase PRMT1 and triggered the binding of ERα methylation to IGF-1R. Mechanistically, they showed that PRMT1 bound constitutively to IGF-1R and that PRMT1 became activated upon IGF-1 stimulation. [Oncogene] Full Article p53 Controls the Plasticity of Mammary Luminal Progenitor Cells Downstream of Met Signaling Consistently, p53-deficient luminal progenitors displayed increased proliferative and self-renewal activities in culture. However, they did not exhibit perturbed expression of luminal-specific markers and major regulators, such as Hey1, Elf5, and Gata3. [Breast Cancer Res] Full Article Scientists demonstrated that human breast cancer cell lines MDA-MB-231, MDA-MB-468, MCF-7, and T47D were differentially affected by statins. Whereas the vitality of MDA-MB-231 and MDA-MB-468 cells was reduced by up to 60% using atorvastatin, simvastatin, or rosuvastatin, only marginal effects were seen in T47D and MCF-7 cells following exposure to statins. [Cell Death Dis] Full Article M1 macrophage-derived exosomes activated NFкB to reverse quiescent breast cancer (BC) cells (BCCs) to cycling cells. Using an in vivo model of BC dormancy, injected M1 MOs sensitized BCCs to carboplatin and increased host survival. [Cell Death Dis] Full Article Investigators showed that siRNA-mediated loss-of-cadherin 11 (siCDH11) function decreased β-catenin, Met, c-Myc, and matrix metalloproteinase 7 expression level in MDA-MB-231 and Hs578t cells. Immunofluorescence staining showed that siCDH11 reduced β-catenin nuclear localization and attenuated triple negative breast cancer cell migration, invasion and tumorsphere-formation. [J Clin Med] Abstract | Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSThe authors summarize available data on feasibility and documented benefits of monitoring of essential invasive breast carcinoma biological features in circulating tumor cells, with special reference to multifactorial proteomic, genomic, and transcriptomic panels of known prognostic or predictive value. [Cancers] Full Article Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications There are some very interesting questions being tackled by researchers as they pertain to altered metabolism in breast cancer. Investigators address these issues along with the latest updates in the field of breast cancer metabolism. [Cells] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSHorizon Discovery Group plc announced that it has entered into an exclusive strategic partnership with Rutgers University to develop and commercialize a novel gene editing technology, known as base editing. The technology potentially has applications in the development of new cell therapies and will augment Horizon’s research tools and services. [Horizon Discovery Group plc (Business Wire, Inc.)] Press Release BCRFA Donates $1 Million to O’Neal Comprehensive Cancer Center The Breast Cancer Research Foundation of Alabama presented its largest donation ever of $1 million to the O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham (UAB). This year’s contribution brings the Birmingham-based organization’s cumulative total for breast cancer research at UAB to more than $8.7 million. [University of Alabama at Birmingham] Press Release | |
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POLICY NEWSA 25% Pay Raise? That’s Not Nearly Enough, Young Indian Scientists Say In response to months of protests and marches, the Indian government announced yesterday that it will give early-career scientists raises of up to 25%. But leaders of the protest movement, who had asked for an 80% hike, immediately rejected the offer. [ScienceInsider] Editorial Few Open-Access Journals Meet Requirements of Plan S, Study Says Only a small proportion of open-access scientific journals fully meet the draft requirements of Plan S, the initiative primarily by European funders to make all papers developed with their support free to read, a study has found. Compliance with the rules could cost the remaining journals, especially smaller ones, more than they can afford. [ScienceInsider] Editorial
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EVENTSNEW Gordon Research Conference: IGF and Insulin System in Physiology and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW International Scientific Director – Breast Cancer (Roche) Postdoctoral Researcher – Breast Cancer (The Royal College of Surgeons in Ireland) Research Fellowship – Cancer Biology (University of Dundee) Postdoctoral Fellowship – Breast Cancer (Cold Spring Harbor Laboratory) Postdoctoral Fellowship – Cancer Research (North Carolina Central University) Postdoctoral Fellowship – Breast Cancer (University of Bergen) Postdoctoral Fellow – Breast Cancer Research (City of Hope) Faculty Position – Molecular Cancer Biology (University of Pittsburgh) Faculty Position – Breast Cancer (University of Texas MD Anderson Cancer Center) Postdoctoral Associate – Cancer (University of Miami) Postdoctoral Position – Breast Cancer (Northwestern University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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