Mammary Cell News 11.07 February 28, 2019 | |
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TOP STORYBreast Cancer Cells Rely on Environmental Pyruvate to Shape the Metastatic Niche Researchers discovered that pyruvate uptake induced the production of α-ketoglutarate. This metabolite in turn activated collagen hydroxylation by increasing the activity of the enzyme collagen prolyl-4-hydroxylase. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Precise Targeting of POLR2A as a Therapeutic Strategy for Human Triple Negative Breast Cancer Through in silico analysis, scientists identified POLR2A in the TP53-neighboring region as a collateral vulnerability target in triple negative breast cancer (TNBC) tumors, suggesting that its inhibition via small interfering RNA may be an amenable approach for TNBC targeted treatment. [Nat Nanotechnol] Abstract | Press Release In human breast tumor xenografts, inhibition of the PAR-complex-mediated SNAI1 degradation mechanism promoted tumor invasion and metastasis. Analyses of human breast tissue samples revealed negative correlations between PAR3 and SNAI1 protein levels. [Nat Cell Biol] Abstract When applied to human triple-negative breast cancer cells, investigators observed proportionality between stimulation and both receptor internalization and inhibitor response, reflecting stimulation heterogeneity contributions to intrinsic variability. [Nat Commun] Full Article | Press Release The depletion of α-parvin from triple-negative breast cancer cells effectively inhibited breast cancer cell growth, migration, and invasion in vitro, and tumor progression and metastasis in vivo. [Oncogene] Abstract Estradiol Induces BDNF/TrkB Signaling in Triple-Negative Breast Cancer to Promote Brain Metastases Conditioned media from estradiol-treated astrocytes activated tropomyosin kinase receptor B (TrkB) and downstream AKT, ERK, and PLC-γ signaling in triple-negative breast cancer cells, increasing their invasiveness and tumor-initiating capability in vitro. [Oncogene] Full Article miR-873/PD-L1 Axis Regulates the Stemness of Breast Cancer Cells PD-L1 expression was positively correlated with the expression of stemness markers, and overexpression of PD-L1 contributed to chemoresistance and stemness-like properties in breast cancer cells via activating PI3K/Akt and ERK1/2 pathways. [EBioMedicine] Full Article In vitro assay of gain- and loss-of-function of FUN14 domain-containing 1 (FUNDC1) suggested that FUNDC1 could stimulate breast cancer cell proliferation, migration and invasion. [EBioMedicine] Full Article S1PR1 Regulates the Switch of Two Angiogenic Modes by VE-Cadherin Phosphorylation in Breast Cancer The authors showed that sphingosine-1-phosphate receptor 1 (S1PR1) regulated RhoA activation to accelerate VE-cadherin phosphorylation, leading to increased endothelium-dependent vessel and reduced vasculogenic mimicry angiogenesis in breast cancer. [Cell Death Dis] Full Article Fibrous sheath-interacting protein 1 (FSIP1) knockout in breast cancer cells significantly increased their sensitivity to docetaxel both in vitro and in vivo. [Cell Death Dis] Full Article Reciprocal Transrepression between FOXF2 and FOXQ1 Controls Basal-Like Breast Cancer Aggressiveness Researchers demonstrated that FOXF2 recruited nuclear receptor corepressor 1 and histone deacetylase 3 to the FOXQ1 promoter to inhibit its transcription in basal-like breast cancer cells, but FOXQ1 did not exert such an effect on FOXF2. [FASEB J] Abstract Interplay of lncRNA H19/miR-675 and lncRNA NEAT1/miR-204 in Breast Cancer In cell culture experiments, the influence of long non-coding RNAs (lncRNAs) on proliferation and apoptosis of breast cancer cell line MCF-7 was examined. A competitive impact on cell proliferation and apoptosis by these lncRNAs was also documented. [Mol Oncol] Abstract | Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSThe authors focus on the combined effect of three compounds on conventional cancer therapy with the objective of observing enhanced efficacy compared with single treatments. [Cancer] Abstract Long-Term Safety and Real-World Effectiveness of Trastuzumab in Breast Cancer Investigators review the evidence available from three major databases, namely PubMed, EMBASE and the Cochrane Central Register of Controlled Trials, to explore and critically discuss key issues related to the long-term safety and effectiveness of trastuzumab in clinical practice. [J Clin Med] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSFDA Approves Herceptin Hylecta for Subcutaneous Injection in Certain HER2-Positive Breast Cancers Roche announced that the FDA has approved Herceptin Hylecta™ for subcutaneous injection for the treatment of certain people with HER2-positive early breast cancer in combination with chemotherapy and HER2-positive metastatic breast cancer in combination with paclitaxel or alone in people who have received one or more chemotherapy regimens for metastatic disease. [Roche Group] Press Release Nearly $20 Million Awarded by CPRIT to MD Anderson The University of Texas MD Anderson Cancer Center was awarded $19.6 million from the Cancer Prevention and Research Institute of Texas (CPRIT) to support research, recruitment and prevention efforts. [The University of Texas MD Anderson Cancer Center] Press Release | |
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POLICY NEWSPioneering ‘Live-Code’ Article Allows Scientists to Play With Each Other’s Results The online journal eLife has created its first “computationally reproducible” article, in which figures are integrated with the software, data and computational environment required to produce them. Readers can change the underlying code and produce modified figures in order to better understand, validate or build on the work. [Nature News] Editorial Big Pharma Is Embracing Open-Access Publishing Like Never Before In a literature analysis, researchers found that the proportion of open-access papers published by 23 large drug companies, such as Pfizer and Roche, almost doubled between 2009 and 2016, and has overtaken the proportion of freely available papers published generally in medicine-related fields. [Nature News] Editorial Spanish Science Reforms Aim to Make Life Easier for Parents The Spanish government has passed reforms to the nation’s scientific system that will cut red tape and make life easier for researchers – especially parents. The reforms make it easier for public research institutions to hire staff, and for scientists to buy equipment and return to a science career after taking a maternity or paternity leave. [Nature News] Editorial NIH Apologizes for Its Failure to Address Sexual Harassment in Science The National Institutes of Health (NIH) apologized for its past failures to recognize and address the culture of sexual harassment that has impacted scientists for generations. “To all those who have endured these experiences, we are sorry that it has taken so long to acknowledge and address the climate and culture that has caused such harm,” NIH Director Francis Collins said in a statement. [STAT News] Editorial
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EVENTSNEW Gordon Research Conference: Hormone-Dependent Cancers Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Cancer Immunology (The Jackson Laboratory) Higher Scientific Officer – Breast Cancer Organoids (Institute of Cancer Research) Scientific Review Officer – Breast Cancer (METAvivor) Faculty Position – Breast Cancer Research (The Mayo Clinic) Postdoctoral Fellow – Cancer Bioinformatics (BC Cancer Research Center, PHSA) Postdoctoral Fellowship – Breast Cancer (Providence John Wayne Cancer Institute) International Scientific Director – Breast Cancer (Roche) Postdoctoral Researcher – Breast Cancer (The Royal College of Surgeons in Ireland) Research Fellowship – Cancer Biology (University of Dundee) Postdoctoral Fellowship – Breast Cancer (Cold Spring Harbor Laboratory) Postdoctoral Fellowship – Cancer Research (North Carolina Central University) Postdoctoral Fellow – Breast Cancer Research (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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