Mammary Cell News 11.22 June 13, 2019 | |
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TOP STORYTargeting non-coding RNA in the aldehyde dehydrogenase 1A pathway (NRAD1) in triple-negative breast cancer tumors using antisense oligonucleotides reduced cell survival, tumor growth, and the number of cells with cancer stem cell characteristics. [Cell Death Differ] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)s-SHIP Promoter Expression Identifies Mouse Mammary Cancer Stem Cells The authors showed that in mammary tumors originating in bitransgenic mice, s-SHIP promoter expression enriched a rare cell population with cancer stem cell activity as demonstrated by sphere-forming assays in vitro and limiting dilution transplantation in vivo. [Stem Cell Reports] Full Article Researchers present a workflow for the analysis of procainamide-labelled glycosphingolipid glycans using high performance liquid chromatography ion mobility-mass spectrometry and a new, automated glycan identification strategy whereby multiple glycan attributes were combined to increase accuracy in automated structural assignments. [Anal Chem] Abstract Investigators compared MCF-7 breast cancer cell responses to cisplatin in traditional two-dimensional (2D) and in 3D-reconstituted basement membrane cell culture models. The results showed a substantial increase of cisplatin resistance mediated by the 3D microenvironment. [Cell Death Dis] Full Article The authors explored a systems pharmacology approach that integrated drug-target networks and large-scale genomic profiles of triple-negative breast cancer and identified wogonoside, one of the major active flavonoids, as a potent angiogenesis inhibitor. [Cell Chem Biol] Abstract | Graphical Abstract MPPED2 expression was decreased in breast cancer samples, and this was confirmed by the analysis of data available in The Cancer Genome Atlas. Interestingly, the hypermethylation of MPPED2 promoter likely accounted for its downregulation in breast cancer. [Cancers] Full Article Exosomes derived from lymphatic endothelial cells (LECs) significantly increased the migration and invasion of MDA-MB-231 in vitro, but ELK3 suppression significantly diminished the pro-oncogenic activity of exosomes from LECs. [Sci Rep] Full Article Seven miRNAs were predicted targeting 11 key glycolytic proteins: miR-140-5p, miR-3064-5p, miR-152-3p, miR-449b-5p, miR-449a, miR-194-5p and miR-34a-5p. Among them, miR-140-5p was found to be downregulated in breast cancer and directly targeted GLUT1, resulting in an antiglycolytic and antiproliferative effect. [Epigenomics] Abstract Scientists evaluated the effects of alpha-mangostin on endoplasmic reticulum (ER) stress and autophagy in human breast cancer cells. Cell apoptosis was markedly promoted by inhibiting ER stress and autophagy while treating cells with alpha-mangostin. [Cancer Cell Int] Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSESR1 Mutations: A New Biomarker in Breast Cancer The authors review currently available data on ESR1 mutations, regarding their functional impact, prevalence at different stages, prognostic impact and predictive value of resistance to aromatase inhibitors. Possible strategies to overcome this resistance by using selective estrogen receptor downregulators are also discussed. [Expert Rev Mol Diagn] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSImmunicom, Inc. began treating its first of 170 triple-negative breast cancer patients at the Jagiellonian University Medical College – Hospital in Cracow, Poland. [Immunicom, Inc. (PR Newswire Association LLC)] Press Release Crick and Imperial Team Awarded £2M Grant to Explore the Physics of Cancer Crick group leaders Guillaume Salbreux and Axel Behrens, along with Chris Dunsby from Imperial College London, have been awarded a £2 million grant from the Engineering and Physical Sciences Research Council. [Francis Crick Institute Ltd.] Press Release | |
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POLICY NEWSEmory Scientist Was Told to Vacate His Office. He Says Move Is Reprisal for Activism on Asian Ties A tenured professor of anesthesiology at Emory University in Atlanta says he is being targeted by school administrators because of a letter he and other faculty members sent its president urging her to defend foreign scientists on campus and the value of international collaborations. [ScienceMagazine] Editorial US-China Tensions Leave Some Researchers on Edge Changing policy has left academics uncertain about what is legal for foreign involvement in research, and increased hostility and bureaucracy have led students and scholars to seek opportunities elsewhere. [The Scientist] Editorial
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EVENTSNEW European Congress on Clinical and Translational Medicine (EUSTM) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Cancer Drug Response Research (University of Texas at Austin) Canada Research Chair – Precision and Molecular Oncology (University of Calgary) PhD Studentship – Molecular Mechanisms of Breast and Colorectal Cancers (Dalhousie University) Senior Global Medical Director – Breast Cancer (F.Hoffmann-La Roche) Postdoctoral Fellow or Research Scientist – Cancer Biology (Icahn School of Medicine at Mount Sinai) Postdoctoral Associate – Immune Responses (The Jackson Laboratory) Postdoctoral Fellows – Bioinformatics (IRCCS European Institute of Oncology) Postdoctoral Fellowship – PcG-Mediated Mechanisms in Breast Cancer (University of Miami) Postdoctoral Fellowship – Tumor Suppressor CSMD1 (Lund University) Postdoctoral Associate – Cancer Immunology (The Jackson Laboratory) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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