 | | Vol. 14.24 – 30 June, 2022 |
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| Scientists developed walking dead TNBC cells through conjugating anti-programmed death protein 1 inhibitor and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Combination therapy of Ceritinib and Enzalutamide were investigated using androgen receptor positive breast cancer mouse xenograft models.
[Molecular Cancer] |
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| Investigators showed that deubiquitinase OTUD6A was involved in the DNA damage response and was important to maintaining genomic stability.
[Cell Death & Differentiation] |
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| Researchers identified CTF1/CT-1 as an activator of autophagy in fibroblasts and breast cancer-derived carcinoma-associated fibroblasts and they showed that CTF1 stimulated phosphorylation and nuclear translocation of STAT3.
[Autophagy] |
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| Scientists used porous 3D scaffolds, designed with two different porosities along with 2D tissue culture polystyrene plates were used with a model breast cancer human cell line.
[ACS Applied Materials & interfaces] |
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| Investigators explored the cell-membrane proteome of a HER2+ breast-cancer cell line to identify triggers responsible for uncontrolled cell proliferation and intrinsic resources that enable detection and therapeutic interventions.
[Scientific Reports] |
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| Using 2D-QSAR approach the authors have designed library of 15 molecules containing benzothiazole analogues that could detect breast cancer cell and inhibit its proliferation.
[Scientific Reports] |
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| DDR2 and/or IFITM1 were knocked down in BT20 and MDA-MB-231 cells, after which the viability, mobility and apoptosis of the cells were tested.
[Journal of Cancer Research and Clinical Oncology] |
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| MY11 inhibited the growth of MDA-MB-231 and MCF-7 breast cancer cells by arresting the cell cycle and promoting apoptosis, through regulation of the cell cycle and apoptosis-related proteins.
[Investigational New Drugs] |
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| Thymoquinone (TQ), a natural compound, has been found to be effective against TNBC cells, and scientists identified IL17RD as a novel target of TQ in TNBC cells.
[BMC Cancer] |
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| The authors discuss the molecular and epigenetic mechanisms underlying breast cancer progression and resistance as well as various aspects of epigenetic-based therapies.
[Cellular & Molecular Biology Letters] |
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| Three Canadian scientists have been recognized by UBC’s Faculty of Medicine for their outstanding scientific accomplishments, and for their potential to make further contributions in their fields.
[UBC Faculty of Medicine] |
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| November 7 – 8, 2022
London, England, United Kingdom |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Pennsylvania State University – State College, Pennsylvania, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Georgetown University – Washington, DC, United States |
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| | University of Vermont – Burlington, Vermont, United States |
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